NCT02676648

Brief Summary

The goal of the research is to optimize an online and mobile multicomponent 12-month diet and lifestyle intervention for improving the blood glucose control of individuals with type 2 diabetes.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
44

participants targeted

Target at P25-P50 for not_applicable diabetes-mellitus-type-2

Timeline
Completed

Started Feb 2016

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2016

Completed
2 days until next milestone

First Submitted

Initial submission to the registry

February 3, 2016

Completed
5 days until next milestone

First Posted

Study publicly available on registry

February 8, 2016

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 15, 2017

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 15, 2017

Completed
Last Updated

August 9, 2021

Status Verified

August 1, 2021

Enrollment Period

1.8 years

First QC Date

February 3, 2016

Last Update Submit

August 6, 2021

Conditions

Outcome Measures

Primary Outcomes (1)

  • HbA1c

    Change in HbA1c from baseline to 12 months post baseline

    12 months

Secondary Outcomes (1)

  • Body Weight Percent Lost

    12 months

Study Arms (8)

Experimental: Condition 1

EXPERIMENTAL

1\) core program; 2) breath meter; 3) text messages; 4) diet-appropriate food and cookbooks

Behavioral: Multicomponent online programBehavioral: Breath meterBehavioral: Text messagesBehavioral: Diet-appropriate foods and cookbooks

Experimental: Condition 2

EXPERIMENTAL

1\) core program

Behavioral: Multicomponent online program

Experimental: Condition 3

EXPERIMENTAL

1\) core program; 2) breath meter

Behavioral: Multicomponent online programBehavioral: Breath meter

Experimental: Condition 4

EXPERIMENTAL

1\) core program; 2) text messages

Behavioral: Multicomponent online programBehavioral: Text messages

Experimental: Condition 5

EXPERIMENTAL

1\) core program; 2) diet-appropriate food and cookbooks

Behavioral: Multicomponent online programBehavioral: Diet-appropriate foods and cookbooks

Experimental: Condition 6

EXPERIMENTAL

1\) core program; 2) breath meter; 3) text messages

Behavioral: Multicomponent online programBehavioral: Breath meterBehavioral: Text messages

Experimental: Condition 7

EXPERIMENTAL

1\) core program; 2) breath meter; 3) diet-appropriate food and cookbooks

Behavioral: Multicomponent online programBehavioral: Breath meterBehavioral: Diet-appropriate foods and cookbooks

Experimental: Condition 8

EXPERIMENTAL

1\) core program; 3) text messages; 4) diet-appropriate food and cookbooks

Behavioral: Multicomponent online programBehavioral: Text messagesBehavioral: Diet-appropriate foods and cookbooks

Interventions

The core program includes information developed in earlier research with individuals with type 2 diabetes, now modified for online delivery: very low-carbohydrate diet taught with lectures on video, handouts, quizzes, and surveys. We also teach participants about the importance of physical activity and adequate sleep, in addition to psychological skills (positive affect, mindful eating) intending to help with intervention adherence.

Experimental: Condition 1Experimental: Condition 2Experimental: Condition 3Experimental: Condition 4Experimental: Condition 5Experimental: Condition 6Experimental: Condition 7Experimental: Condition 8
Breath meterBEHAVIORAL

We will send participants a breath meter to test ketones in their breath, to assess dietary adherence.

Experimental: Condition 1Experimental: Condition 3Experimental: Condition 6Experimental: Condition 7
Text messagesBEHAVIORAL

We will send participants text messages, to support intervention adherence.

Experimental: Condition 1Experimental: Condition 4Experimental: Condition 6Experimental: Condition 8

We will send participants diet-appropriate foods and cookbooks, to support intervention adherence.

Experimental: Condition 1Experimental: Condition 5Experimental: Condition 7Experimental: Condition 8

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • overweight or obese
  • English-speaking
  • diagnosis of type 2 diabetes (HbA1c \> 6.5%)
  • regular access to the internet and text messages

You may not qualify if:

  • taking diabetes medications other than metformin
  • being pregnant or breastfeeding
  • currently undergoing cancer treatments
  • untreated serious mental illness

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Michigan

Ann Arbor, Michigan, 48109, United States

Location

Related Publications (1)

  • Saslow LR, Moskowitz JT, Mason AE, Daubenmier J, Liestenfeltz B, Missel AL, Bayandorian H, Aikens JE, Kim S, Hecht FM. Intervention Enhancement Strategies Among Adults With Type 2 Diabetes in a Very Low-Carbohydrate Web-Based Program: Evaluating the Impact With a Randomized Trial. JMIR Diabetes. 2020 Sep 9;5(3):e15835. doi: 10.2196/15835.

    PMID: 32902391BACKGROUND

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Officials

  • Laura Saslow, PhD

    University of Michigan

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

February 3, 2016

First Posted

February 8, 2016

Study Start

February 1, 2016

Primary Completion

November 15, 2017

Study Completion

November 15, 2017

Last Updated

August 9, 2021

Record last verified: 2021-08

Data Sharing

IPD Sharing
Will not share

Locations