How Much Reliable iv Calcium for the Treatment of Hyperkalemia?

NCT02672930 | Completed

• 1 other identifier: 230
• Study Type: observational
• Target: 111
• Locations: 1 country
• Sites: 1

Brief Summary

Hyperkalemia is a common problem in the emergency services and one of the life threatening metabolic emergencies. Calcium, insulin, beta adrenoceptor agonists, bicarbonate, diuretics, sodium polystyrene sulfonate and lastly dialysis are advised in treatment. Especially, avoiding evolution of serious arrythmias and iv calcium using in the treatment of occured electrocardiogram (ECG) abnormalities, there is not sufficient level of survey in the literature. So the aim of this study was to evaluate administration of iv calcium efficiency on vital signs and ECG.

Conditions

Acute Renal Failure; Chronic Renal Failure

Keywords

calcium gluconate; hyperpotassemia treatment

Outcome Measures

Primary Outcomes (1)

• ECG changes after the calcium infusion

  10 minutes

Secondary Outcomes (2)

• Pulse changes after the calcium infusion

  10 minutes

• Blood pressure changes after the calcium infusion

  10 minutes

Interventions

Electrocardiogram (ECG) DEVICE

ECG and vital parameters were obtained before and after recommended standard calcium gluconate therapy for hyperkalemia

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Blood potassium levels above 5.5 and all patients with ECG changes due hyperpotassemia were included in the study.

You may qualify if:

• All patients who had ECG changes due to hyperpotassemia (K\>5.5 mmol/l)

You may not qualify if:

• Arrest patients
• Patients needed antiarrhythmic interventions
• Patients need inotropic that may cause ECG changes
• Patients need atropine during emergency treatment prior to Ca-gluconate
• Patients needed cardioversion or defibrillation
• Hyperpotassemia with myocardial infarction
• In the presence of other situations which changes ECG for example pericarditis
• Unstabile patients for ideal ECG
• Digoxin usage
• Trauma
• blood calcium level of \> 10.5 mg/dl

Sponsors & Collaborators

• Haseki Training and Research Hospital: lead

Study Sites (1)

Haseki Training and Reseurch Hospital

Istanbul, 34096, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Acute Kidney Injury; Kidney Failure, Chronic

Interventions

Electrocardiography

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Renal Insufficiency, Chronic; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis

Study Officials

• Adnan Yamanoğlu, MD

  Emergency Department

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Emergency Medicine Specialist

Study Record Dates

• First Submitted: January 17, 2016
• First Posted: February 3, 2016
• Study Start: July 1, 2015
• Primary Completion: July 1, 2016
• Study Completion: July 1, 2017
• Last Updated: March 2, 2021

Record last verified: 2020-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)