Study of Metatinib Tromethamine Tablet

NCT02650375 | Unknown Phase 1

• 1 other identifier: SIM-128-I-02
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 3

Brief Summary

This is an open-label, multicenter study designed to assess the safety, tolerability, preliminary efficacy and pharmacokinetics of Metatinib Tromethamine tablet in patients with advanced or metastatic gastric cancer, liver cancer, colorectal cancer,or con squamous NSCLC. Patients receive Metatinib orally 200mg once daily (QD) or 100mg twice daily (BID) until disease progression or unacceptable toxicity occurred. The study will determine whether MET gene mutation, amplification, as well as MET protein overexpression in tumor tissue correlate with treatment efficacy and clinical outcome. The potential PD biomarker for Metatinib will also be explored.

Conditions

Advanced or Metastatic Gastric Cancer; Advanced or Metastatic Liver Cancer; Advanced or Metastatic CRC; Advanced or Metastatic Non Squamous NSCLC

Outcome Measures

Primary Outcomes (1)

• incidence of adverse events

  until 30 days after the last dose

Secondary Outcomes (10)

• Objective response rate

  every 6 weeks, up to 2 years

• Disease control rate

  every 6 weeks, up to 2 years

• Progression free survival

  every 6 weeks, up to 2 years

• Overall survival

  every 6 weeks, up to 2 years

• Cmax for Metatinib

  day 1,day 2,day 8,day15,day22

Study Arms (1)

Metatinib Tromethamine

EXPERIMENTAL

Drug: Metatinib Tromethamine

Interventions

Metatinib Tromethamine DRUG

Patients receive Metatinib orally 200mg once daily (QD) or 100mg twice daily (BID) until disease progression or unacceptable toxicity occurred.

Metatinib Tromethamine

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with advanced or metastatic gastric cancer or colorectal cancer who progress after second-line therapy or the above treatment protocol, or patients with advanced or metastatic hepatocellular carcinoma who progress after first-line chemotherapy, interventional therapy or targeted therapy shall be verified by histology or cytology; or patients with advanced or metastatic non-squamous non-small cell lung cancer who cannot be operated or fail to first-line therapy shall be verified by histology or cytology;
• MET gene amplification or protein overexpression(IHC ≥2+）,or exon-14 skipping;
• At least one measurable lesion (RECIST 1.1 );
• At least 4 weeks from the last chemotherapy, radiotherapy or anti-tumor biological products treatment; at least 8 weeks from the last anti-tumor antibody products treatment; at least 6 weeks from the last dose of nitrosourea, mitomycin C or doxorubicin;
• At least 4 weeks from major surgery or trauma, and the wound should fully heal; at least 1 week from minor surgery or trauma (i.e. tissue biopsy or fine needle aspiration);
• Toxicity from previous treatment has to restore to ≤ grade 1, baseline or irreversible (NCI CTC4.0);
• ECOG performance status 0-1;
• Life expectancy ≥3 months;
• Adequate hematologic function: ANC≥1.5×10\^9 /L, HB≥90g/L(blood transfusion allowed), PLT≥100×10\^9/L;
• Adequate hepatic function: ALT≤3×ULN, AST≤3×ULN, TBIL≤2×ULN(patients with liver metastases or liver cancer ALT≤5×ULN, AST≤5×ULN, TBIL≤2×ULN), Child-Pugh score≤7;
• Adequate renal function: uric acid\<500μmol/L, creatinine\<1.7mg/dL, proteinuria≤2＋or≤2g/24h , GFR≥60 ml/min/1.73m\^2;
• PT-INR/APTT≤1.5×ULN, Serum sodium, potassium, calcium, magnesium levels ≤1×ULN(NCI-CTC 4.0);
• Patients signed written informed consent;
• Willingness and capability to comply with protocol requirement and well communicate with investigators.

You may not qualify if:

• Severe, uncontrolled medical disorders or active infection, including but not limited to HIV antibody positive, active tuberculosis, HBV DNA copies\>10\^3/ml;
• Subjects have known or suspected brain metastases;
• Patients must receive other chemotherapy, targeted therapy, hormone therapy, immunotherapy, radiotherapy (except for palliative local radiation) or traditional Chinese medicine for treatment of cancer during the study;
• Previously received other VEGF/VEGFR small-molecule inhibitors or antibodies therapy, including but not limited to Bevacizumab, Ramucirumab, Aflibercept;
• Previously received other HGF/c-Met small-molecule inhibitors or antibodies therapy, including but not limited to Crizotinib, Cabozantinib, Volitinib, Capmatinib (INC280), BPI-9016M;
• Imaging showed involvement of major blood vessels or nerves by tumor;
• Uncontrolled hypertension (systolic blood pressure\>150mmHg and/or diastolic blood pressure\>100mmHg after treatment);
• LVEF\<50%;
• Apparent heart disease, including congestive heart failure(NYHA III-IV), history of myocardial infarction, or uncontrolled angina within 6 months prior to enrollment;
• Arrhythmias need to be treated, including atrial fibrillation, supraventricular tachycardia, ventricular tachycardia or ventricular fibrillation; ECG abnormalities confirmed, including QT interval prolongation (males\>450msec, females\>470 msec);
• History of hemorrhagic or thrombotic events within 6 months before enrollment, i.e. cerebrovascular accidents(including TIA), pulmonary embolism, spontaneous hemorrhage of tumor;
• Patients need surgery within 28 days, or is expected to require surgery within 28 days after the last dose;
• Uncontrolled cavity effusion, such as large amount of pleural effusion and ascites;
• Gastrointestinal illnesses(i.e., uncontrolled diarrhea or malabsorption) at screening or within 3 months that may affect drug absorption;
• History or suspicious signs of gastrointestinal perforation;

Sponsors & Collaborators

• Jiangsu Simcere Pharmaceutical Co., Ltd.: lead

Study Sites (3)

The First Bethune Hospital of Jilin University

Changchun, Jilin, 130021, China

RECRUITING

West China Hospital, Sichuan University

Chengdu, Sichuan, 610041, China

RECRUITING

The First Affiliated Hospital, Zhejiang University

Hangzhou, Zhejiang, 310003, China

RECRUITING

MeSH Terms

Conditions

Stomach Neoplasms; Liver Neoplasms

Condition Hierarchy (Ancestors)

Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Stomach Diseases; Liver Diseases

Study Officials

• Feng Bi, MD

  West China Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Shuangling Deng, MS

CONTACT

86-025-85560000; dengshuangling@simcere.com

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 10, 2015
• First Posted: January 8, 2016
• Study Start: October 1, 2015
• Primary Completion: October 1, 2017
• Study Completion: February 1, 2018
• Last Updated: January 23, 2017

Record last verified: 2017-01

Locations

CN (3)