Sensory Properties of Bowel Cleansing Solutions

NCT02642783 | Completed DMC

• 1 other identifier: NUT.AO.19
• Study Type: interventional
• Target: 14
• Locations: 0 countries
• Sites: N/A

Brief Summary

Samples of 4 commercially available bowel cleansing solutions, namely PEG-electrolyte + ascorbic acid (PEG-Asc, Moviprep®, Norgine, UK), PEG-electrolyte (PEG, Fortrans® Ibsen, France), sodium picosulfate/magnesium citrate (SPS, Picoprep®, Ferring, Switzerland), and oral sodium sulfate (OSS, Izinova®, Ibsen, France) were prepared according to the manufacturer's instructions. Descriptive analysis was conducted with trained panelists (N= 14) to create a sensory profile for the solutions and generated attributes were rated on an unstructured 15-cm line scale using the Compusense at-hand® (Guelph, Canada) sensory evaluation software. Acceptability testing was carried out with untrained participants (N=80) and samples were rated on the 9-point hedonic scale. Moreover, a Just-About-Right (JAR) scale was included for the four basic tastes to determine their compatibility with optimum taste/acceptability levels in the products.

Conditions

Laxative Bowel Cleansing Solutions

Keywords

laxatives; sensory evaluation; acceptability; colonoscopy

Outcome Measures

Primary Outcomes (1)

• rating of sensory attributes

  participants attended 4 training sessions during which they generated sensory descriptive attributes specific for the tasted laxative solutions. In addition, they evaluated the laxative samples by rating generated attributes on a 15-cm unstructured line scale using compusense at-hand sensory evaluation software.

  3 weeks

Secondary Outcomes (2)

• Acceptability Score

  1 week

• Just about right score

  1 week

Study Arms (2)

Descriptive analysis

OTHER

panelists were asked to rate different sensory attributes for different laxative bowel cleansing solutions on a 15 cm line scale.

Behavioral: Descriptive analysis

Acceptability test

OTHER

panelists were asked to rate the acceptability of different laxative bowel cleansing solutions using the 9-point hedonic scale.

Behavioral: acceptability test

Interventions

Descriptive analysis BEHAVIORAL

subjects were asked to assess the sensory profile by tasting the laxative bowel cleansing solutions, namely: Moviprep, picoprep, fortrans and isinova

Descriptive analysis

acceptability test BEHAVIORAL

subjects were asked to assess the acceptability of the laxative bowel cleansing solutions, namely: Moviprep, picoprep, fortrans and isinova

Acceptability test

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• age between 18 and 50 years

You may not qualify if:

• allergies to polyethelene glycol (PEG), artificial sweeteners

Sponsors & Collaborators

• American University of Beirut Medical Center: lead

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: December 22, 2015
• First Posted: December 30, 2015
• Study Start: November 1, 2015
• Primary Completion: December 1, 2015
• Study Completion: December 1, 2015
• Last Updated: December 30, 2015

Record last verified: 2015-12

Data Sharing

• IPD Sharing: Will not share