NCT02638220

Brief Summary

Iiopathic bilateral cataracts occur in many children with Cerebrotendinous Xanthomatosis (CTX) so the opportunity to use contact with health care providers in connection with pediatric cataract evaluation and treatment is a promising avenue for disease detection and prevention.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
442

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Sep 2015

Longer than P75 for all trials

Geographic Reach
1 country

44 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2015

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

November 23, 2015

Completed
1 month until next milestone

First Posted

Study publicly available on registry

December 23, 2015

Completed
5.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 19, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 19, 2021

Completed
3.6 years until next milestone

Results Posted

Study results publicly available

September 19, 2024

Completed
Last Updated

September 19, 2024

Status Verified

June 1, 2023

Enrollment Period

5.5 years

First QC Date

November 23, 2015

Results QC Date

June 8, 2023

Last Update Submit

April 30, 2024

Conditions

Keywords

Cerebrotendinous XanthomatosisCTX Prevalence StudyCTXIdiopathic Bilateral CataractsCataractsBilateral CataractsEarly-Onset Idiopathic Bilateral CataractsObservational StudyOphthalmology

Outcome Measures

Primary Outcomes (1)

  • Number of Participants Who Had Positive Genetic Test Results

    genetic test results

    At genetic testing

Eligibility Criteria

Age2 Years - 21 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Early-Onset Idiopathic Bilateral Cataracts

You may qualify if:

  • The patient has a diagnosis of idiopathic bilateral cataracts
  • Between the ages of 2 to 21 years at the time of diagnosis

You may not qualify if:

  • The patient has a diagnosis of cataracts with known etiology other than CTX
  • The patient has a diagnosis of CTX
  • The patient has cataracts caused by cataractogenic treatments
  • The patient has taken or is currently taking cholic acid or chenodeoxycholic acid
  • The patient has participated in an interventional clinical trial in the past 30 days
  • The patient and/or their parent/legal guardian, in the opinion of the Investigator, is unable to adhere to the requirements of the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (44)

Travere Investigational Site

Birmingham, Alabama, 35294, United States

Location

Travere Investigational Site

La Jolla, California, 92093, United States

Location

Travere Investigational Site

Los Angeles, California, 90027, United States

Location

Travere Investigational Site

Los Angeles, California, 90095, United States

Location

Travere Investigational Site

Palo Alto, California, 94303, United States

Location

Travere Investigational Site

Aurora, Colorado, 80045, United States

Location

Travere Investigational Site

Gainesville, Florida, 32608, United States

Location

Travere Investigational Site

Jacksonville, Florida, 32207, United States

Location

Travere Investigational Site

Atlanta, Georgia, 30322, United States

Location

Travere Investigational Site

Chicago, Illinois, 60611, United States

Location

Travere Investigational Site

Indianapolis, Indiana, 46202, United States

Location

Travere Investigational Site

Iowa City, Iowa, 52242, United States

Location

Travere Investigational Site

Louisville, Kentucky, 40202, United States

Location

Travere Investigational Site

New Orleans, Louisiana, 70121, United States

Location

Travere Investigational Site

Baltimore, Maryland, 21201, United States

Location

Travere Investigational Site

Boston, Massachusetts, 02115, United States

Location

Travere Investigational Site

Ann Arbor, Michigan, 48105, United States

Location

Travere Investigational Site

Detroit, Michigan, 48201, United States

Location

Travere Investigational Site

Kansas City, Missouri, 64108, United States

Location

Travere Investigational Site

St Louis, Missouri, 63103, United States

Location

Travere Investigational Site

The Bronx, New York, 10467, United States

Location

Travere Investigational Site

Chapel Hill, North Carolina, 27517, United States

Location

Travere Investigational Site

Durham, North Carolina, 27708, United States

Location

Travere Investigational Site

Cincinnati, Ohio, 45229, United States

Location

Travere Investigational Site

Cleveland, Ohio, 44106, United States

Location

Travere Investigational Site

Columbus, Ohio, 43205, United States

Location

Travere Investigational Site

Oklahoma City, Oklahoma, 73104, United States

Location

Travere Investigational Site

Portland, Oregon, 97239-3098, United States

Location

Travere Investigational Site

Tigard, Oregon, 97223, United States

Location

Travere Investigational Site

Philadelphia, Pennsylvania, 19104, United States

Location

Travere Investigational Site

Philadelphia, Pennsylvania, 19107, United States

Location

Travere Investigational Site

Charleston, South Carolina, 29425, United States

Location

Travere Investigational Site

Germantown, Tennessee, 38103, United States

Location

Travere Investigational Site

Nashville, Tennessee, 37232, United States

Location

Travere Investigational Site

Houston, Texas, 77025, United States

Location

Travere Investigational Site

Houston, Texas, 77030, United States

Location

Travere Investigational Site

Salt Lake City, Utah, 84113, United States

Location

Travere Investigational Site

Norfolk, Virginia, 23502, United States

Location

Travere Investigational Site

Richmond, Virginia, 23298, United States

Location

Travere Investigational Site

Seattle, Washington, 98105, United States

Location

Travere Investigational Site

Spokane, Washington, 99204, United States

Location

Travere Investigational Site

Tacoma, Washington, 98405, United States

Location

Travere Investigational Site

Morgantown, West Virginia, 26506, United States

Location

Travere Investigational Site

Milwaukee, Wisconsin, 53226, United States

Location

MeSH Terms

Conditions

Xanthomatosis, CerebrotendinousCataract

Condition Hierarchy (Ancestors)

Lipid Metabolism, Inborn ErrorsMetabolism, Inborn ErrorsGenetic Diseases, InbornCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesLipid Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesXanthomatosisLens DiseasesEye Diseases

Limitations and Caveats

This was an observational study; no treatment was administered and therefore no efficacy assessment was conducted. The results presented are used to evaluate the prevalence of CTX in a patient population diagnosed with early-onset idiopathic bilateral cataracts. Only SAEs that were related to a research procedure (eg, blood sample collection) were to be recorded.

Results Point of Contact

Title
Cheryl Wong Po Foo/Director, Clinical Development
Organization
Travere Therapeutics, Inc.

Study Officials

  • Executive Director, Clinical Development Nephrology

    Travere Therapeutics, Inc.

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
Yes

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 23, 2015

First Posted

December 23, 2015

Study Start

September 1, 2015

Primary Completion

February 19, 2021

Study Completion

February 19, 2021

Last Updated

September 19, 2024

Results First Posted

September 19, 2024

Record last verified: 2023-06

Locations