Attention/Working Memory Rehabilitation in Multiple Sclerosis: A Pilot Project Using Cogmed Working Memory Training

NCT02634567 | Completed

• 1 other identifier: 107343
• Study Type: interventional
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

Patients diagnosed with any type of multiple sclerosis (MS) who show objective evidence of attention problems will be randomized to standard medical care (treatment as usual) or attention training, which will be completed at their home using a commercially available attention training task (Cogmed Working Memory Training - CWMT) for 5 weeks. Patients will undergo cognitive testing before and after intervention and at 6 months follow up.

Conditions

Multiple Sclerosis

Outcome Measures

Primary Outcomes (3)

• Paced Auditory Serial Addition Test

  Cognitive test; Change pre- to post-test between groups

  7 months

• Symbol Digit Modalities Test

  Cognitive test; Change pre- to post-test between groups

  7 months

• Stroop colour word test

  Cognitive test; Change pre- to post-test between groups

  7 months

Secondary Outcomes (19)

• Judgement of Line Orientation

  7 months

• Controlled Oral Word Association Test

  7 months

• California Verbal Learning Test

  7 months

• Brief Visual Memory Test

  7 months

• Delis-Kaplan Executive Function System Sorting Test

  7 months

Study Arms (2)

Treatment as Usual

NO INTERVENTION

This group will not any training with the Cogmed training program.

Training Group

EXPERIMENTAL

This group will receive intervention with the Cogmed training program and coach over a period of 5 weeks.

Behavioral: Cogmed Working Memory Training (CWMT)

Interventions

Cogmed Working Memory Training (CWMT) BEHAVIORAL

The CWMT (Cogmed) method consists of 25 training sessions done online. Each participant assigned to the training group will complete eight exercises for five weeks with five sessions every week. Each session consists of a selection of various tasks that target the different aspects of attention/working memory. Participants will engage in weekly discussions over the phone for about 1 hour with an assigned Cogmed coach who will provide support and encouragement over the 5 weeks.

Training Group

Eligibility Criteria

• Age: 18 Years - 64 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Males/Females, Ages 18-64, with any type of MS
• Lower to moderate physical disability
• Demonstrated impaired attention/working memory on 2 of 3 measures (Patients with a z-score lower than -1.5 on at least 2 of the 3 measures will be characterized as showing attention/working memory deficits)
• Patients must have a Mac or personal computer (PC) computer at home with access to the internet

You may not qualify if:

• Clinical relapse/steroid treatment 1 month prior to study entry
• Physical disability that prevents completion of study measures or training
• History of severe mental illness or daily marijuana use

Sponsors & Collaborators

• London Health Sciences Centre: lead

Study Sites (1)

London Health Sciences Centre

London, Ontario, N6A 5A5, Canada

Location

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Sarah A Morrow, MD, MS, FRCPC (Neurology)

  London Health Sciences Centre

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, MS, FRCPC (Neurology)

Study Record Dates

• First Submitted: December 11, 2015
• First Posted: December 18, 2015
• Study Start: April 1, 2016
• Primary Completion: November 1, 2018
• Study Completion: December 1, 2018
• Last Updated: August 13, 2019

Record last verified: 2019-08

Locations

CA (1)