Intra-Articular 0.5 % Lidocaine Injection for Osteoarthritis
1 other identifier
interventional
52
0 countries
N/A
Brief Summary
In this study, investigators compared the efficacy of intra-articular 0.5% lidocaine and saline injection on pain, stiffness and physical function in patients with osteoarthritis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_4 chronic-pain
Started Dec 2009
Longer than P75 for phase_4 chronic-pain
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2015
CompletedFirst Submitted
Initial submission to the registry
December 3, 2015
CompletedFirst Posted
Study publicly available on registry
December 16, 2015
CompletedDecember 16, 2015
December 1, 2015
5.2 years
December 3, 2015
December 14, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Pain scores according to visual analog scale
3 months after the treatment
Study Arms (2)
intra-articular 0.5% lidocaine
ACTIVE COMPARATORintra-articular 7 mL 0.5% lidocaine injection for 3 times with one week intervals
intra-articular saline
ACTIVE COMPARATORintra-articular 7 mL saline injection for 3 times with one week intervals
Interventions
Eligibility Criteria
You may qualify if:
- knee pain for more than 25 of the past 30 days, morning stiffness or less than 30 minutes, crepitation in the knee
- pain for more than 25 of the past 30 days and osteophytes on x-ray examination of the knees indicating knee OA
You may not qualify if:
- the knees with a history of mechanical derangement, fibromyalgia, skin lesions and other risk factors of infection, therapy with anticoagulants and trauma/surgery
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- H. Evren Ekerlead
- Baskent Universitycollaborator
Related Publications (2)
Elhakim M, Nafie M, Eid A, Hassin M. Combination of intra-articular tenoxicam, lidocaine, and pethidine for outpatient knee arthroscopy. Acta Anaesthesiol Scand. 1999 Sep;43(8):803-8. doi: 10.1034/j.1399-6576.1999.430804.x.
PMID: 10492407BACKGROUNDPietruck C, Grond S, Xie GX, Palmer PP. Local anesthetics differentially inhibit sympathetic neuron-mediated and C fiber-mediated synovial neurogenic plasma extravasation. Anesth Analg. 2003 May;96(5):1397-1402. doi: 10.1213/01.ANE.0000060454.34258.D3.
PMID: 12707141BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Anis Aribogan, Prof
Coordinator
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Ass Prof
Study Record Dates
First Submitted
December 3, 2015
First Posted
December 16, 2015
Study Start
December 1, 2009
Primary Completion
March 1, 2015
Study Completion
August 1, 2015
Last Updated
December 16, 2015
Record last verified: 2015-12
Data Sharing
- IPD Sharing
- Will not share