Effect of High-carbohydrate or High-monounsaturated Fat on Blood Pressure: Meta-analysis of Randomized Clinical Trials

NCT02626325 | Unknown

• 1 other identifier: CHO-MUFA Meta
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

High saturated fat acids diets are associated with elevated blood pressure which is associated with cardiovascular morbidity and mortality. For this reason, a change of diet is recommended to manage blood pressure and prevent cardiovascular complications. To achieve this nutritional goal, a high-carbohydrate diet or high-monounsaturated fat diet can be advised in the replacement of a saturated fat diet. Previous meta-analysis of Garg (1998) cited randomized articles with inconsistent blood pressure lowering after consumption of a high-monounsaturated-fat diet compared with a high-carbohydrate diet only in type 2 diabetes patients. Moreover, another meta-analysis of Shah et al. (2007) showed slightly high blood pressure on diets rich in carbohydrates than diets rich in cis-monounsaturated fat after randomized and nonrandomized articles. For this reason, a new meta-analysis of a randomized clinical trial will be performed to clarify the effects of high-carbohydrate or high-monounsaturated fat diets on blood pressure. Results from this meta-analysis will help health professionals take important decisions on patient diet and minimize cardiovascular morbidity and mortality.

Conditions

Blood Pressure

Outcome Measures

Primary Outcomes (2)

• Blood pressure

  3 weeks

• Mean arterial pressure

  3 weeks

Interventions

High-carbohydrate or High-monounsaturated fat diets OTHER

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Healthy and unhealthy (T2DM, hyperlipidemic, hypertensive)

You may qualify if:

• Randomized controlled trials
• Parallel or Crossover Design
• Duration: at least 3 weeks
• Isocaloric diet

Sponsors & Collaborators

• Unity Health Toronto: lead

Study Sites (1)

Vladimir Vuksan

Toronto, Ontario, M5C2T2, Canada

Location

Related Publications (1)

• Jovanovski E, de Castro Ruiz Marques A, Li D, Ho HVT, Blanco Mejia S, Sievenpiper JL, Zurbau A, Komishon A, Duvnjak L, Bazotte RB, Vuksan V. Effect of high-carbohydrate or high-monounsaturated fatty acid diets on blood pressure: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2019 Jan 1;77(1):19-31. doi: 10.1093/nutrit/nuy040.

  PMID: 30165599 DERIVED

Study Officials

• Vladimir Vuksan, PhD

  Unity Health Toronto

  PRINCIPAL INVESTIGATOR

• Elena Jovanovskie, MSc

  Unity Health Toronto

  PRINCIPAL INVESTIGATOR

• Any de Castro Ruiz Marques, MSc

  Unity Health Toronto

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 7, 2015
• First Posted: December 10, 2015
• Study Start: November 1, 2015
• Primary Completion: July 1, 2016
• Study Completion: July 1, 2016
• Last Updated: July 6, 2016

Record last verified: 2016-07

Locations

CA (1)