The Genetic and Affective Prediction Study

NCT02625818 | Completed

• 1 other identifier: 2014/1751
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

A major proportion of patients admitted to psychiatric acute and emergency departments have symptoms, behaviors or function influenced by implicit or explicit suicidal intention (tendency towards self-harm, or suicide attempt). There is an increased risk of suicide in the acute phase during in-patient stay and after discharge. At present there is no satisfactory tool to predict post-discharge suicide risk. Multidimensional rating is expected to have better predictive properties than one-dimensional rating for suicidal behavior during in -patient stay and two years after discharge. Multidimensional rating assesses anxiety, panic, agitation, suicidal thoughts and ideations, as well as therapist's reactions during interviews. In the present study the predictive properties of two rating scales for suicidal behavior during in-patient stay and two years after will be compared. One of these is a multidimensional scale: "Multidimensional Assessment of Suicide Risk" (MARIS).

Conditions

Mental Disorders

Keywords

Emergency Services, Psychiatric; Prognosis; Biological markers; Anxiety; Panic; Psychomotor Agitation; Self-injurious Behavior

Outcome Measures

Primary Outcomes (1)

• self-inflicted, potentially injurious behavior with intention to die defined as acts needing attendance by physician

  during in-patient stay

  2 weeks

Secondary Outcomes (1)

• suicide

  2 years after discharge

Study Arms (1)

acute psychiatric condition

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients admitted to the psychiatric acute department for central Norway, St Olavs University Hospital, Trondheim. The department has a catchment area of approximately 240000 inhabitants ≥ 18 years. The hospital has close to 2000 admittances each year

You may qualify if:

• acute agitated condition
• informed consent

You may not qualify if:

• Drug abuse
• in-patient stay for a fixed time at regular intervals

Sponsors & Collaborators

• St. Olavs Hospital: lead
• Norwegian University of Science and Technology: collaborator

Study Sites (1)

St Olavs Hospital, Østmarka psychiatric department

Trondheim, Norway

Location

Biospecimen

Retention: SAMPLES WITH DNA

blood samples (plasma and serum)

MeSH Terms

Conditions

Mental Disorders; Anxiety Disorders; Psychomotor Agitation; Self-Injurious Behavior

Condition Hierarchy (Ancestors)

Dyskinesias; Neurologic Manifestations; Nervous System Diseases; Psychomotor Disorders; Neurobehavioral Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Aberrant Motor Behavior in Dementia; Behavioral Symptoms; Behavior

Study Officials

• Randolf Terje Vågen

  St Olavs Hospital, Division of Mental Health Care

  STUDY DIRECTOR

• Nanna Sønnichsen Kayed

  Department of Mental Health, Faculty of Medicine and Health, NTNU

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 4, 2015
• First Posted: December 9, 2015
• Study Start: January 1, 2016
• Primary Completion: January 1, 2020
• Study Completion: January 1, 2021
• Last Updated: November 21, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

NO (1)