Phototherapy and Cryotherapy in Post-exercise Skeletal Muscle Recovery

NCT02622971 | Completed DMC

• 1 other identifier: CEP 470.174
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Volunteers were divided randomly in five experimental groups. VAS (Visual Analogic scale) to measure DOMS (Delayed Onset Muscle Soreness) and blood samples was taken before any procedure. Then, volunteers performed stretching and warm-up followed by MVC test (isometric test in isokinetic dynamometer to measure muscle function). After, volunteers performed the exercise protocol (75 eccentric contractions) to lead to muscle fatigue. Immediately after exercise protocol (1 minute) and 1 hour, 24, 48, 72 and 96 hours after, blood sample, VAS measure and MVC test were repeated. The treatments according to randomisation were performed three minutes after exercise protocol and it were performed again in 24, 48, 72h after eccentric exercise. The variables regarding to muscle function (MVC, DOMS) and the indirect marker of muscle damage (CK activity) were monitored in all time points mentioned above (baseline, 1 minute, 1 hour, 24, 48, 72 and 96 hours after exercise protocol).

Conditions

Post-exercise Muscle Recovery

Keywords

phototherapy; cryotherapy; exercise; fatigue; recovery

Outcome Measures

Primary Outcomes (1)

• Maximum voluntary contraction (MVC)

  The MVC test consisted of three five-second isometric contractions of the knee extensors of the non-dominant leg. The highest torque value of the three contractions (peak torque) was used for statistical analysis.

  one week

Secondary Outcomes (2)

• Evaluation of Delayed Onset Muscle Soreness (DOMS)

  one week

• CK (Creatine Kinase) activity

  one week

Study Arms (5)

PBMT and Cryotherapy

ACTIVE COMPARATOR

Volunteers allocated in this group received phototherapy (PBMT - applied in six points of quadriceps) and cryotherapy (20 minutes in PRICE protocol) as a treatment three minutes and 24h, 48h and 72h after exercise protocol.

Other: PBMT; Other: Cryotherapy

Cryotherapy and PBMT

ACTIVE COMPARATOR

Volunteers allocated in this group received cryotherapy (20 minutes in PRICE protocol) and phototherapy (PBMT - applied in six points of quadriceps) as a treatment three minutes and 24h, 48h and 72h after exercise protocol.

Other: PBMT; Other: Cryotherapy

PBMT (active phototherapy)

ACTIVE COMPARATOR

Volunteers allocated in this group received active phototherapy (PBMT - applied in six points of quadriceps) as a treatment three minutes and 24h, 48h and 72h after exercise protocol.

Other: PBMT

PBMT (placebo phototherapy)

PLACEBO COMPARATOR

Volunteers allocated in this group received placebo phototherapy (PBMT - applied in six points of quadriceps) as a treatment three minutes and 24h, 48h and 72h after exercise protocol. The placebo PBMT device was identical to the active devices and displayed the same settings and emitted the same sound regardless of the comparator.

Other: PBMT

Cryotherapy

ACTIVE COMPARATOR

Volunteers allocated in this group cryotherapy (20 minutes in PRICE protocol) as a treatment three minutes and 24h, 48h and 72h after exercise protocol. Two flexible ice packs filled with ice cubes and water (with a volume of 1.15 liters each) were used in order to cover the entire quadriceps. Rubber belts were used to apply compression and to affix the packs tightly to the volunteers' quadriceps.

Other: Cryotherapy

Interventions

PBMT OTHER

Effects of phototherapy isolated and/or combined with cryotherapy in post-exercise skeletal muscle recovery.

Also known as: photobiomodulation therapy

Cryotherapy and PBMT; PBMT (active phototherapy); PBMT (placebo phototherapy); PBMT and Cryotherapy

Cryotherapy OTHER

Effects of cryotherapy isolated and/or combined with phototherapy in post-exercise skeletal muscle recovery.

Cryotherapy; Cryotherapy and PBMT; PBMT and Cryotherapy

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Subjects were included in the study if they performed less than 2 exercise session per week

You may not qualify if:

• Subjects were excluded if occurred any musculoskeletal injury to hips or knees within the previous two months,
• if they were currently using pharmacological agents or nutritional supplements regularly,
• if a musculoskeletal injury during the study occurred or if they reported use of either alcohol or tobacco.

Sponsors & Collaborators

• University of Nove de Julho: lead
• Multi Radiance Medical: collaborator

Study Sites (1)

Laboratory of Phototherapy in Sports and Exercise, Universidade Nove de Julho (UNINOVE)

São Paulo, São Paulo, 01504-001, Brazil

Location

Related Publications (6)

• Antonialli FC, De Marchi T, Tomazoni SS, Vanin AA, dos Santos Grandinetti V, de Paiva PR, Pinto HD, Miranda EF, de Tarso Camillo de Carvalho P, Leal-Junior EC. Phototherapy in skeletal muscle performance and recovery after exercise: effect of combination of super-pulsed laser and light-emitting diodes. Lasers Med Sci. 2014 Nov;29(6):1967-76. doi: 10.1007/s10103-014-1611-7. Epub 2014 Jun 19.

  PMID: 24942380 RESULT

• Grandinetti Vdos S, Miranda EF, Johnson DS, de Paiva PR, Tomazoni SS, Vanin AA, Albuquerque-Pontes GM, Frigo L, Marcos RL, de Carvalho Pde T, Leal-Junior EC. The thermal impact of phototherapy with concurrent super-pulsed lasers and red and infrared LEDs on human skin. Lasers Med Sci. 2015 Jul;30(5):1575-81. doi: 10.1007/s10103-015-1755-0. Epub 2015 May 19.

  PMID: 25987340 RESULT

• Baroni BM, Leal Junior EC, De Marchi T, Lopes AL, Salvador M, Vaz MA. Low level laser therapy before eccentric exercise reduces muscle damage markers in humans. Eur J Appl Physiol. 2010 Nov;110(4):789-96. doi: 10.1007/s00421-010-1562-z. Epub 2010 Jul 3.

  PMID: 20602109 RESULT

• Graham CA, Stevenson J. Frozen chips: an unusual cause of severe frostbite injury. Br J Sports Med. 2000 Oct;34(5):382-3. doi: 10.1136/bjsm.34.5.382.

  PMID: 11049150 RESULT

• Moeller JL, Monroe J, McKeag DB. Cryotherapy-induced common peroneal nerve palsy. Clin J Sport Med. 1997 Jul;7(3):212-6. doi: 10.1097/00042752-199707000-00011.

  PMID: 9262890 RESULT

• Bassett FH 3rd, Kirkpatrick JS, Engelhardt DL, Malone TR. Cryotherapy-induced nerve injury. Am J Sports Med. 1992 Sep-Oct;20(5):516-8. doi: 10.1177/036354659202000505.

  PMID: 1443317 RESULT

MeSH Terms

Conditions

Motor Activity; Fatigue

Interventions

Low-Level Light Therapy; Cryotherapy

Condition Hierarchy (Ancestors)

Behavior; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Laser Therapy; Therapeutics; Phototherapy

Study Officials

• Ernesto Cesar P Leal-Junior, PhD, PT

  University of Nove de Julho

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD candidate

Study Record Dates

• First Submitted: November 24, 2015
• First Posted: December 7, 2015
• Study Start: June 1, 2014
• Primary Completion: December 1, 2015
• Study Completion: January 1, 2016
• Last Updated: February 3, 2016

Record last verified: 2016-02

Data Sharing

• IPD Sharing: Will share

Locations

BR (1)