Correlation of Platelets Count With Endoscopic Findings in a Cohort of Egyptian Patients With Liver Cirrhosis

NCT02621372 | Unknown DMC

• 1 other identifier: non invasive diagnosis of EV
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Portal hypertension is a common complication of liver cirrhosis that can lead to development of esophageal varices (EV). They are abnormally dilated veins within the wall of the esophagus that lead to haemorrhage (1). Majority of patients with cirrhosis will develop EV at some point, and about third of these patients will have at least one bleeding episode because of rupture of a varix . For this reason, screening endoscopy for detection of the presence of EV should be part of the diagnostic work-up in patients with cirrhosis. This is a very important preventive step for identification of those patients with variceal bleeding risk and furthermore, identification of patients in urgent need for prophylactic treatment. All guidelines stress on screening endoscopy for early detection of EV in cirrhotic patients with portal hypertension. However this approach is limited by its invasiveness and cost effectiveness issues of screening endoscopy .

Conditions

Portal Hypertension

Outcome Measures

Primary Outcomes (1)

• Number of patients with esophageal varices and have low platelet count

  1 year

Interventions

platelet count OTHER

Correlation of esophageal varices with platelet count

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

A total of 110 cirrhotic patients were included

You may qualify if:

• Diagnosis of cirrhosis based on history, physical examination, laboratory tests, ultrasound scans and liver biopsy in some occasion.

You may not qualify if:

• Hepatocellular carcinoma.
• Portal vein thrombosis.
• Parenteral drug addiction.

Sponsors & Collaborators

• Sherief Abd-Elsalam: lead
• Tanta University: collaborator

Study Sites (1)

Tropical medicine dept.-Tanta university hospital

Tanta, Egypt

RECRUITING

MeSH Terms

Conditions

Hypertension, Portal

Interventions

Platelet Count

Condition Hierarchy (Ancestors)

Liver Diseases; Digestive System Diseases

Intervention Hierarchy (Ancestors)

Blood Cell Count; Cell Count; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Hematologic Tests; Platelet Function Tests; Investigative Techniques; Cell Physiological Phenomena; Blood Physiological Phenomena; Circulatory and Respiratory Physiological Phenomena

Study Officials

• Sherief Abd-Elsalam

  Tanta university hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sherief M Abd-Elsalam, lecturer

CONTACT

00201095159522; sherif_tropical@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Hepatology and gastroenterology dept., tanta university, M.D., Principle investigator

Study Record Dates

• First Submitted: November 27, 2015
• First Posted: December 3, 2015
• Study Start: January 1, 2015
• Primary Completion: September 1, 2019
• Study Completion: October 1, 2019
• Last Updated: June 20, 2017

Record last verified: 2017-06

Locations

EG (1)