NCT02616081

Brief Summary

The investigators goal is to create a better understanding of patient reported outcomes for bladder management strategies (clean intermittent catheterization (CIC), indwelling catheter (IDC) and bladder surgery.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,479

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2016

Typical duration for all trials

Geographic Reach
1 country

3 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

November 13, 2015

Completed
13 days until next milestone

First Posted

Study publicly available on registry

November 26, 2015

Completed
1 month until next milestone

Study Start

First participant enrolled

January 1, 2016

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2018

Completed
Last Updated

November 9, 2021

Status Verified

November 1, 2021

Enrollment Period

2.5 years

First QC Date

November 13, 2015

Last Update Submit

November 3, 2021

Conditions

Keywords

Urinary BladderNeurogenicQuality of LifeSpinal cord injuryincontinenceBladder

Outcome Measures

Primary Outcomes (3)

  • Neurogenic Bladder Symptom Score (NBSS): comparing change in: CIC, IDC, Voiding, and Surgery

    The NBSS quantifies bladder symptoms

    Baseline and 1 year longitudinal follow up

  • The Spinal Cord Injury Quality of Life Measurement System Bladder Management Difficulties (SCI-QOL Difficulties): comparing change in: CIC, IDC, Voiding, and Surgery

    The SCI-QoL Difficulties assesses feelings and psychosocial impact of bladder symptoms

    Baseline and 1 year longitudinal follow up

  • The Spinal Cord Injury Quality of Life Measurement System Bladder Complications (SCI-QOL Complications): comparing change in: CIC, IDC, Voiding, and Surgery

    The SCI-QoL Complications assesses degree of bladder complications their psychosocial impact

    Baseline and 1 year longitudinal follow up

Secondary Outcomes (4)

  • NBSS Incontinence subdomain

    Baseline and 1 year longitudinal follow up

  • NBSS Storage and Voiding subdomain

    Baseline and 1 year longitudinal follow up

  • NBSS Consequences subdomain

    Baseline and 1 year longitudinal follow up

  • NBSS QoL Satisfaction

    Baseline and 1 year longitudinal follow up

Study Arms (4)

Clean Intermittent Catheterization

Participants performing intermittent catheterization of their bladder, having not had augmentation cystoplasty or creation of a catheterizable channel

Other: Clean Intermittent Catheterization

Indwelling Catheter

Participants utilizing an Foley catheter or a suprapubic tube (cystostomy)

Other: Indwelling Catheter

Surgery

Undergoing any of the following surgeries: augmentation cystoplasty with or without a catheterizable channel, creation of catheterizable channel alone, urinary diversion (conduit or continent catheterizable pouch)

Other: Surgery

Voiding

Participants with volitional control, voiding into diapers or a condom catheter via crede, valsalva, or spontaneous leakage

Other: Voiding

Interventions

Clean intermittent self catheterization is a standard of care.

Clean Intermittent Catheterization

Indwelling catheterization is a standard of care.

Indwelling Catheter
SurgeryOTHER

Bladder surgery is a standard of care.

Surgery
VoidingOTHER

Voiding spontaneously is a standard of care.

Voiding

Eligibility Criteria

Age18 Years - 100 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Participants with neurogenic bladder with urinary issues and currently being managed by one/ any of various bladder management treatments (clean intermittent catheterization, indwelling catheter, voiding or bladder surgery).

You may qualify if:

  • Participants with acquired spinal cord injury
  • Participants with neurogenic bladder
  • Participants must be undergoing or starting at least one of the following bladder management treatments at the time of enrollment. a) Clean intermittent catheterization (CIC) b) Have an indwelling catheter (IDC) c) Spontaneous voiding, and d) Have undergone bladder surgery
  • Age 18 or older
  • Willingness and ability to comply with study engagement
  • Able to provide consent

You may not qualify if:

  • Degenerative spinal cord issues, such as multiple sclerosis, neuromuscular dysfunction
  • Congenital spinal cord issues, such as spina bifida, myelomeningocele, or cerebral palsy
  • Participants that belong to a vulnerable population (pregnant, prisoners, mentally handicapped, etc)
  • Participants less than 18 years of age

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

University of Michigan

Ann Arbor, Michigan, 48109, United States

Location

University of Minnesota

Minneapolis, Minnesota, 55455, United States

Location

University of Utah

Salt Lake City, Utah, 84132, United States

Location

Related Publications (2)

  • Patel DP, Lenherr SM, Stoffel JT, Elliott SP, Welk B, Presson AP, Jha A, Rosenbluth J, Myers JB; Neurogenic Bladder Research Group. Study protocol: patient reported outcomes for bladder management strategies in spinal cord injury. BMC Urol. 2017 Oct 10;17(1):95. doi: 10.1186/s12894-017-0286-3.

  • Crescenze IM, Lenherr SM, Myers JB, Elliott SP, Welk B, O'Dell D, Stoffel JT. Self-Reported Urological Hospitalizations or Emergency Room Visits in a Contemporary Spinal Cord Injury Cohort. J Urol. 2021 Feb;205(2):477-482. doi: 10.1097/JU.0000000000001386. Epub 2020 Oct 9.

Related Links

MeSH Terms

Conditions

Urinary Bladder, NeurogenicSpinal Cord Injuries

Interventions

Intermittent Urethral CatheterizationCatheters, IndwellingSurgical Procedures, OperativeUrination

Condition Hierarchy (Ancestors)

Neurologic ManifestationsNervous System DiseasesUrinary Bladder DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsSpinal Cord DiseasesCentral Nervous System DiseasesTrauma, Nervous SystemWounds and Injuries

Intervention Hierarchy (Ancestors)

Urinary CatheterizationCatheterizationTherapeuticsInvestigative TechniquesCathetersEquipment and SuppliesUrinary Tract Physiological PhenomenaReproductive and Urinary Physiological Phenomena

Study Officials

  • Jeremy O Myers, MD

    University of Utah School of Medicine - Urology

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor - School of Medicine

Study Record Dates

First Submitted

November 13, 2015

First Posted

November 26, 2015

Study Start

January 1, 2016

Primary Completion

June 30, 2018

Study Completion

June 30, 2018

Last Updated

November 9, 2021

Record last verified: 2021-11

Data Sharing

IPD Sharing
Will not share

Locations