NCT02614378

Brief Summary

Evaluate the effectiveness of air insufflation in aborting (stopping) an acute episode of migraine and compare it with a placebo effect of using the same procedure but without active insufflation. The insufflation will be used when the subject is experiencing an acute episode of migraine to determine its ability to reduce, if not to completely eliminate the migraine symptoms. Subjects receiving the placebo treatment will be offered the active treatment during the subsequent episode of migraine.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
58

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Nov 2015

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2015

Completed
20 days until next milestone

First Submitted

Initial submission to the registry

November 21, 2015

Completed
4 days until next milestone

First Posted

Study publicly available on registry

November 25, 2015

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2016

Completed
Last Updated

December 14, 2016

Status Verified

December 1, 2016

Enrollment Period

1.1 years

First QC Date

November 21, 2015

Last Update Submit

December 13, 2016

Conditions

Keywords

abortive effect

Outcome Measures

Primary Outcomes (1)

  • Changes in Symptoms severity scale

    Subjects will grade the severity of their symptoms on a scale from 0 to 10. Changes in the symptoms severity scale will be assessed between pre and immediately post treatment

    pre-treatment, immediately post-treatment

Secondary Outcomes (3)

  • Changes in Symptoms severity scale at 2h

    pre-treatment, 2h post-treatment

  • Changes in Symptoms severity scale at 24h

    pre-treatment, 24h post-treatment

  • Changes in blood pressure

    pre-treatment, immediately post-treatment

Study Arms (2)

Subject receiving treatment

ACTIVE COMPARATOR

participant receiving air insufflation

Procedure: air insufflation

Subject receiving placebo

PLACEBO COMPARATOR

participant not receiving air insufflation

Procedure: placebo

Interventions

modulated air insufflation of the ear canal

Subject receiving treatment
placeboPROCEDURE

no air will be introduced in the ear canal

Subject receiving placebo

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adult subjects suffering from acute migraine episodes
  • Possibly located in the Phoenix, AZ area

You may not qualify if:

  • Pregnant/nursing women

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Buckler Chiropractic

Phoenix, Arizona, 85044, United States

Location

Doctor's office

Scottsdale, Arizona, 85254, United States

Location

MeSH Terms

Conditions

Migraine Disorders

Condition Hierarchy (Ancestors)

Headache Disorders, PrimaryHeadache DisordersBrain DiseasesCentral Nervous System DiseasesNervous System Diseases

Study Officials

  • Frederick R Carrick, PhD

    Carrick Institute for Graduate Studies

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

November 21, 2015

First Posted

November 25, 2015

Study Start

November 1, 2015

Primary Completion

December 1, 2016

Study Completion

December 1, 2016

Last Updated

December 14, 2016

Record last verified: 2016-12

Data Sharing

IPD Sharing
Will not share

Locations