Water Drinking Test in Patients With Occludable Angle

NCT02613533 | Completed

• 1 other identifier: 10-988E
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The water drinking test (WDT), is a predictive test that has been used to detect primary open angle glaucoma and recently has been demonstrated as a predictor of the diurnal tension curve. Clinically accurate provocative tests for asymptomatic eyes with shallow anterior chambers and narrow angles are highly desirable to detect patients prone to angle closure glaucoma. The aim of this pilot study is to evaluate the possible role of water drinking test in patients with narrow angles who are scheduled for prophylactic laser iridotomy.

Conditions

Glaucoma

Outcome Measures

Primary Outcomes (1)

• Intra-ocular pressure measurement

  Twenty patients with occludable angles will be enrolled in this study. After measuring the baseline Intra-ocular pressure, weight and height, the patients will be asked to drink 10ml/kg water over 15 minutes (equal to approximately 2 ½ cups for a 150 lb. individual) and their intra-ocular pressure (IOP) will be checked every 15 minutes up to one hour after drinking the water. This will be repeated after performing a laser peripheral iridotomy (LPI). The data obtained, mainly Intra-ocular pressure will be analyzed using statistical tests and compared to historical controls of the WDT without narrow angles, and laser iridotomy subjects without the WDT.

  every 15 minutes before and after surgery for upto an hour

Study Arms (1)

Narrow Angle Glaucoma Study Group

EXPERIMENTAL

Subjects will be given 10ml/kg of water over 15 min prior to surgery and Intra-ocular pressure measurement (IOP) is checked every 15 min before and after surgical procedure.

Other: Intra-ocular pressure measurement (IOP)

Interventions

Intra-ocular pressure measurement (IOP) OTHER

Subjects will be given 10ml/kg of water over 15 min prior to laser peripheral iridotomy (LPI) surgery and Intra-ocular pressure (IOP) is tested every 15 min before and after surgical procedure

Narrow Angle Glaucoma Study Group

Eligibility Criteria

• Age: 21 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• narrow angle judged to be at risk of attack by the treating physician, with one or more quadrants not open to the sclera spur on gonioscopy
• age between 21 and 90 years
• ability to give informed consent.

You may not qualify if:

• baseline IOP higher than 21 mm Hg with or without medication
• other causes of glaucoma, such as pseudoexfoliative and pigmentary glaucomas
• previous treatment with argon laser or selective laser trabeculoplasty
• previous refractive sugary; (5) pregnant women; (6) congestive heart failure
• renal failure or urinary retention issues; (8) corneal abnormalities preventing reliable IOP measurement
• non-glaucomatous optic neuropathy
• prior refractive surgery or other issues preventing accurate Goldmann applanation tonometry
• prior intraocular surgery

Sponsors & Collaborators

• Wills Eye: lead

Study Sites (1)

Wills Eye Institute

Philadelphia, Pennsylvania, 19107, United States

Location

MeSH Terms

Conditions

Glaucoma

Condition Hierarchy (Ancestors)

Ocular Hypertension; Eye Diseases

Study Officials

• Jonathan Myers, MD

  Wills Eye

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Study Record Dates

• First Submitted: August 10, 2015
• First Posted: November 24, 2015
• Study Start: February 1, 2010
• Primary Completion: January 1, 2015
• Study Completion: January 1, 2015
• Last Updated: November 30, 2017

Record last verified: 2017-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)