Neurohumoral Mechanism of Deferent Frequency Transcutaneous Electrical Acupoint Stimulation(TEAS)
Neurohumor Mechanism of Deferent Frequency Transcutaneous Electrical Acupoint Stimulation(TEAS): A Prospective, Randomized Controlled Trial
1 other identifier
interventional
81
0 countries
N/A
Brief Summary
The purpose of this study is to explore the neurohumoral mechanism of deferent frequency TEAS pretreatment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Dec 2015
Shorter than P25 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 15, 2015
CompletedFirst Posted
Study publicly available on registry
November 20, 2015
CompletedStudy Start
First participant enrolled
December 1, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2016
CompletedNovember 20, 2015
November 1, 2015
4 months
November 15, 2015
November 19, 2015
Conditions
Outcome Measures
Primary Outcomes (2)
Plasma concentration of epinephrine(ng/L)
change of TEAS 0 and 30 minutes
Plasma concentration of norepinephrine(ng/L)
change of TEAS 0 and 30 minutes
Secondary Outcomes (5)
Heart rate variability
During 30min TEAS
plasma concentration of glucocorticoid(μg/L)
change of TEAS 0 and 30 minutes
plasma concentration of aldosterone(ng/L)
change of TEAS 0 and 30 minutes
plasma concentration of renin(ng/L)
change of TEAS 0 and 30 minutes
plasma concentration of β-endorphin(ng/L)
change of TEAS 0 and 30 minutes
Study Arms (3)
2/10HZ TEAS pretreatment
EXPERIMENTALPatients were given 30min of 2/10HZ TEAS before anesthesia
10/50HZ TEAS pretreatment
EXPERIMENTALPatients were given 30min of 10/50HZ TEAS before anesthesia
fake stimulation
SHAM COMPARATORPatients were only attached electrodes without electric current
Interventions
2/10HZ Electric stimulation was given through electrode attached to specific acupoints
Patients were only attached electrodes without electric current
Eligibility Criteria
You may qualify if:
- Age 18yrs-65yrs
- ASA 1-2
- Scheduled for elective operation under general anesthesia
- BMI 18-30kg/m2
- Informed consented
You may not qualify if:
- Contraindications to TEAS
- Communication difficulty with researchers
- Addicted to alcohol, analgesics or other drugs
- Cardiac insufficiency or high blood pressure without controlled
- Hepatic or renal dysfunction
- Participate in the other clinical trial 3 month before the enrollment
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- wangqianglead
Related Publications (1)
Lu Z, Dong H, Wang Q, Xiong L. Perioperative acupuncture modulation: more than anaesthesia. Br J Anaesth. 2015 Aug;115(2):183-93. doi: 10.1093/bja/aev227.
PMID: 26170347BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Doctor
Study Record Dates
First Submitted
November 15, 2015
First Posted
November 20, 2015
Study Start
December 1, 2015
Primary Completion
April 1, 2016
Study Completion
June 1, 2016
Last Updated
November 20, 2015
Record last verified: 2015-11