NCT02611193

Brief Summary

Hypothesis: Manipulative treatment can relieve patients of discomfort and dysfunction and then be utilized as a cheap conservative management of CTS. Study design: Two-groups randomized single-blind interventional study.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
66

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started May 2016

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 23, 2015

Completed
4 months until next milestone

First Posted

Study publicly available on registry

November 20, 2015

Completed
5 months until next milestone

Study Start

First participant enrolled

May 1, 2016

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2017

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2017

Completed
Last Updated

November 20, 2015

Status Verified

November 1, 2015

Enrollment Period

8 months

First QC Date

July 23, 2015

Last Update Submit

November 18, 2015

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change in Boston Carpal Tunnel Questionnaire

    self-administered questionnaire for the assessment of severity of symptoms and functional status in patients who have carpal tunnel syndrome. It has two distinct scales : a symptom-severity scale (11 \- Page 2 of 3 \[DRAFT\] - items) and a functional-status scale (8 items). It has been validated and demonstrated to show good responsiveness and reliability in evaluating outcome after carpal tunnel release. The Spanish version has been validated

    Baseline, 4 weeks, 12 weeks

Secondary Outcomes (4)

  • Change in DASH Outcome Measure

    Baseline, 4 weeks, 12 weeks

  • Change in Visual Analog Scale for pain

    Baseline, 4 weeks, 12 weeks

  • Change in EuroQol-5D scale

    Baseline, 4 weeks, 12 weeks

  • Change in strength (Dynamometer)

    Baseline, 4 weeks, 12 weeks

Study Arms (2)

Manipulative treatment

EXPERIMENTAL

Manipulative Treatment

Procedure: Manipulative treatment

Simulated manipulative treatment

SHAM COMPARATOR

Simulated manipulative treatment

Procedure: Simulated manipulative treatment

Interventions

Manipulative treatment as described by the GBMOIM (Grupo Barcelona de Medicina Ortopédica y Manual) will be perform with extension of the transverse carpal ligament maneuver and fascia release maneuver

Manipulative treatment

Simulated Manipulative Treatment

Simulated manipulative treatment

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Symptoms of canal tunnel syndrome (CTS) : pain, numbness, paresthesia, diminished grip strength
  • Electromyography confirming CTS

You may not qualify if:

  • Previous surgical procedure for CTS in the same wrist
  • Possible secondary CTS : hypothyroidism, diabetes mellitus, pregnancy, rheumatologic diseases, neck or shoulder complaints,
  • Hand and wrist pathological conditions as previous disease, intervention, traumatism, anatomic abnormalities in shape or size.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Carpal Tunnel Syndrome

Interventions

Manipulation, Osteopathic

Condition Hierarchy (Ancestors)

Median NeuropathyMononeuropathiesPeripheral Nervous System DiseasesNeuromuscular DiseasesNervous System DiseasesNerve Compression SyndromesCumulative Trauma DisordersSprains and StrainsWounds and Injuries

Intervention Hierarchy (Ancestors)

Musculoskeletal ManipulationsComplementary TherapiesTherapeuticsPhysical Therapy ModalitiesRehabilitation

Study Officials

  • Julia Schmitt, PM&RResident

    Hospital Arnau de Vilanova, Valencia, Spain

    PRINCIPAL INVESTIGATOR
  • Julio Domenech, MD-PhD

    Hospital Arnau de Vilanova, Valencia, Spain

    STUDY DIRECTOR

Central Study Contacts

Julia Schmitt

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD-PhD

Study Record Dates

First Submitted

July 23, 2015

First Posted

November 20, 2015

Study Start

May 1, 2016

Primary Completion

January 1, 2017

Study Completion

July 1, 2017

Last Updated

November 20, 2015

Record last verified: 2015-11