NCT02610114|Unknown
Improvement of Cell Selection in Reproductive Techniques
A New Method to Improve the Selection of Zygotes in the Context of Assisted Reproductive Medicine. A Randomized Controlled Blinded Monocenter Study
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A New Method to Improve the Selection of Zygotes in the Context of Assisted Reproductive Medicine. A Randomized Controlled Blinded Monocenter Study
Sponsor study identifier
interventional
220
1 country
1
Study Start
December 2015
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
March 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
November 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
It is the aim of this trial to use a new computerized cell selection method, in addition to the current and world-wide used scoring system of fertilized oocytes implemented by Scott, to determine whether this leads to an increase in pregnancy rates in women undergoing assisted reproductive techniques.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
November 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 5, 2015
Actual (reported)November 20, 2015
Actual (reported)December 2015
Date type not reportedThis date has not been verified as actual or estimated.
March 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
November 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Clinical pregnancy
Clinical pregnancy is defined as a pregnancy diagnosed by ultrasonographic visualization of one or more gestational sacs or definitive clinical signs of pregnancy. It includes ectopic pregnancy.
min. 4 weeks after embryo transfer
Ongoing clinical pregnancy
min. 9 weeks after embryo transfer
Life Birth
through study completion, an average of 40 weeks after last menstrual period
In addition to the routine Z-score for zygote selection, if needed, the photographs of the zygotes already taken for quality and safety reasons are analysed using the new computer algorithm. Within a few minutes it generates a score, determining the quality of the cells. The two best cells upon Z-score result and new computer algorithm result are selected for first transfer.
After fertilisation pronuclei and nucleoli can be seen inside the cells by microscope. Routinely, the alignment of nucleoli can be used generating a score, the Z-score 1-4, established by Scott. Two zygotes getting the best Z-score are selected for cell culture and the cells that develop to embryo stage are used for first transfer.
Neue Frauenklinik
Lucerne, 6000 Luzern 16, Switzerland
Jürgen Weiss, Professor
Luzerner Kantonsspital, Neue Frauenklinik
First Submitted
November 5, 2015
First Posted
November 20, 2015
Study Start
December 2015
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
March 2018
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
November 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
March 22, 2017
Record last verified: 2017-03
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Source: ClinicalTrials.gov.
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