Ultra Violet-C Light Evaluation as an Adjunct to Removing Multi-Drug Resistant Organisms (UVCLEAR-MDRO)

NCT02605499 | Completed

• 1 other identifier: IRB00063160
• Study Type: interventional
• Target: 83
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study examines the impact of UV-C light disinfection as an adjunct to routine daily and discharge patient room cleaning on patient infection and colonization with hospital associated bacteria. Patient rooms are counted as enrolled since consent was waived and the number of participants is unknown. Total of 83 rooms.

Conditions

Healthcare Associated Infection; Multidrug Resistant Organisms

Outcome Measures

Primary Outcomes (2)

• Acquisition of Vancomycin Resistant Enterococcus

  Rates of Vancomycin Resistant Enterococcus acquisition will be compared between intervention and control periods.

  2 years

• Acquisition of a composite rate of healthcare-associated bacteria: Vancomycin Resistant Enterococcus, Methicillin Resistant Staphylococcus Aureus, hospital-onset bacteremias, Clostridium difficile, and central line associated bloodstream infections.

  Rates of Vancomycin Resistant Enterococcus, Methicillin Resistant Staphylococcus Aureus, hospital-onset bacteremias, multidrug resistant gram negative bacteria, Clostridium difficile, and central line associated bloodstream infections will be compared between intervention and control periods.

  2 years

Secondary Outcomes (13)

• Acquisition of Vancomycin Resistant Enterococcus (clinical infection)

  2 years

• Acquisition of Vancomycin Resistant Enterococcus (colonization)

  2 years

• Acquisition of Clostridium difficile (infection)

  2 years

• Acquisition of Clostridium difficile (colonization or infection)

  2 years

• Acquisition of bacteremia

  2 years

Study Arms (2)

UV-C light disinfection

EXPERIMENTAL

During intervention UV-C light disinfection will be used in hospital patient rooms as an adjunct to routine daily and discharge cleaning.

Other: UV-C light disinfection

Control

NO INTERVENTION

During control period there will be standard discharge and daily room cleaning only, with no UV-C light disinfection.

Interventions

UV-C light disinfection OTHER

UV-C light disinfection will be used in hospital patient rooms as an adjunct to routine daily and discharge cleaning.

UV-C light disinfection

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient rooms in pre-selected hospital units within Johns Hopkins Hospital

You may not qualify if:

• None, intervention is at level of the hospital unit, not the patient

Sponsors & Collaborators

• Johns Hopkins University: lead

Related Publications (1)

• Rock C, Hsu YJ, Curless MS, Carroll KC, Ross Howard T, Carson KA, Cummings S, Anderson M, Milstone AM, Maragakis LL. Ultraviolet-C Light Evaluation as Adjunct Disinfection to Remove Multidrug-Resistant Organisms. Clin Infect Dis. 2022 Aug 24;75(1):35-40. doi: 10.1093/cid/ciab896.

  PMID: 34636853 DERIVED

MeSH Terms

Conditions

Cross Infection

Condition Hierarchy (Ancestors)

Infections; Iatrogenic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Lisa Maragakis, MD, MPH

  Johns Hopkins University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Patient rooms are counted as enrolled since consent was waived and the number of participants is unknown. Total of 83 rooms.

Study Record Dates

• First Submitted: November 11, 2015
• First Posted: November 16, 2015
• Study Start: December 1, 2015
• Primary Completion: February 1, 2018
• Study Completion: February 1, 2018
• Last Updated: September 19, 2018

Record last verified: 2018-09