Dietary Macronutrient Manipulation and Substrate Oxidation During Exercise

NCT02605291 | Completed

• 1 other identifier: ERN_15-0963
• Study Type: interventional
• Target: 13
• Locations: 1 country
• Sites: 1

Brief Summary

This study will investigate the effect of dietary macronutrient manipulation on glycogen (stored carbohydrate) levels in the muscle and substrate oxidation during exercise. The investigators will investigate the hypothesis that manipulating the macronutrient content of the diet will alter the levels of glycogen in the muscle and, in turn, substrate oxidation during exercise.

Conditions

Dietary Manipulation

Outcome Measures

Primary Outcomes (1)

• Muscle glycogen concentration after dietary macronutrient manipulation

  Muscle glycogen concentration will be measured after the dietary macronutrient manipulation intervention.

  Day 7 of all experimental arms

Secondary Outcomes (8)

• Rate of fat oxidation at rest (g/min)

  For 20 min on Day 7 of all experimental arms

• Rate of fat oxidation during exercise (g/min)

  During 60 min of exercise on day 7 of all experimental arms

• Rate of carbohydrate oxidation at rest (g/min)

  For 20 min on Day 7 of all experimental arms

• Rate of carbohydrate oxidation during exercise (g/min)

  During 60 min of exercise on day 7 of all experimental arms

• Blood glucose concentration

  At 0, 20, 40 and 60min into exercise on day 7 of all experimental arms.

Study Arms (3)

Experimental arm 1

EXPERIMENTAL

One of three 7-day study arms consisting of 3 days of standardised diet followed by 3 days of dietary macronutrient manipulation and 1 day of experimental testing.

Other: Diet with a different macronutrient content A; Other: Interval treadmill running exercise; Other: Steady state treadmill running exercise

Experimental arm 2

EXPERIMENTAL

One of three 7-day study arms consisting of 3 days of standardised diet followed by 3 days of dietary macronutrient manipulation and 1 day of experimental testing.

Other: Diet with a different macronutrient content B; Other: Interval treadmill running exercise; Other: Steady state treadmill running exercise

Experimental arm 3

EXPERIMENTAL

One of three 7-day study arms consisting of 3 days of standardised diet followed by 3 days of dietary macronutrient manipulation and 1 day of experimental testing.

Other: Diet with a different macronutrient content C; Other: Interval treadmill running exercise; Other: Steady state treadmill running exercise

Interventions

Diet with a different macronutrient content A OTHER

A diet with altered macronutrient content will be provided to participants on days 4-6 of experimental arm 1.

Experimental arm 1

Diet with a different macronutrient content B OTHER

A diet with a different macronutrient content compared to arm 1 will be provided to participants on days 4-6 of experimental arm 2.

Experimental arm 2

Diet with a different macronutrient content C OTHER

A diet with a different macronutrient content compared to arms 1 and 2 will be provided to participants on days 4-6 of experimental arm 3.

Experimental arm 3

Interval treadmill running exercise OTHER

Participants will perform interval treadmill running exercise on days 4 and 5 of all experimental arms.

Experimental arm 1; Experimental arm 2; Experimental arm 3

Steady state treadmill running exercise OTHER

Participants will perform steady state treadmill running exercise on day 7 of all experimental arms.

Experimental arm 1; Experimental arm 2; Experimental arm 3

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Good general health
• Non-smoking - currently and for the past 5 years
• Fitness - V̇O2max 40-60 ml/kg/min
• Body mass index (20-25 kg/m2)

You may not qualify if:

• Known or suspected intolerance to the dietary interventions or their stated ingredients.
• Participation in another clinical study or receipt of an investigational drug within 30 days of the screening visit.
• Previous participation in this study.
• Recent history (within the last year) of alcohol or other substance abuse.
• An employee of the sponsor or the study site or members of their immediate family.
• Abnormal / extreme habitual dietary practice / intake
• Recent (≤3 months) dietary practice that may be deemed as low and/or high in macronutrients will be excluded.
• The taking of any prescribed medication

Sponsors & Collaborators

• University of Birmingham: lead
• Lucozade Ribena Suntory: collaborator

Study Sites (1)

School of Sport Exercise and Rehabilitation Sciences, University of Birmingham

Birmingham, B15 2TT, United Kingdom

Location

MeSH Terms

Interventions

Diet

Intervention Hierarchy (Ancestors)

Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena

Study Officials

• Gareth A Wallis, PhD

  University of Birmingham

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 6, 2015
• First Posted: November 16, 2015
• Study Start: January 1, 2016
• Primary Completion: June 1, 2017
• Study Completion: June 1, 2017
• Last Updated: October 11, 2018

Record last verified: 2018-10

Locations

GB (1)