Prevalence of COPD in Our Lung Cancer Population, Compared to Controls

NCT02603627 | Unknown

• 2 other identifiers: RJ115/N10615/YH/0091
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This study will investigate the prevalence of chronic obstructive pulmonary disease (COPD) in patients who are newly diagnosed with lung cancer and compare it to the prevalence of COPD in controls recruited from a smoking cessation clinic.

Conditions

COPD; Lung Cancer; Smoking

Outcome Measures

Primary Outcomes (1)

• Prevalence of COPD in lung cancer compared to controls, using spirometry to diagnose COPD.

  Up to nine months

Secondary Outcomes (2)

• Comparison of the proportion of small cell tumours to non-small cell tumours in patients with lung cancer and COPD.

  Up to nine months

• Comparison of the proportion of individuals with an emphysematous phenotype to the proportion of individuals with a bronchitic phenotype.

  Up to nine months

Study Arms (2)

With lung cancer

Patients who have a new diagnosis of lung cancer will be invited to undergo spirometry to enable us to gather data on the prevalence of COPD in this group.

Without lung cancer

Smokers who are referred to the smoking cessation clinic will be invited to undergo spirometry to ascertain the prevalence of COPD in this group.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients will be recruited from the multidisciplinary lung cancer clinic at Guy's Hospital. Controls will be recruited from the smoking cessation clinic at Guy's and St Thomas' NHS Foundation Trust.

You may qualify if:

• Informed consent
• Aged over 18
• Lung cancer group: new diagnosis of lung cancer, with spirometry results available Control group: spirometry result available or obtained

You may not qualify if:

• Patient refusal
• Age under 18
• Control group: pre-existing lung cancer

Sponsors & Collaborators

• Guy's and St Thomas' NHS Foundation Trust: lead

Study Sites (1)

Guy's and St Thomas' NHS Foundation Trust

London, England, SE1 9RT, United Kingdom

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Lung Neoplasms; Smoking

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Behavior

Study Officials

• Tariq Sethi, MBBS PhD

  King's Health Partners

  PRINCIPAL INVESTIGATOR

• Anthony Dorr, MBBS PhD

  Guy's and St Thomas' NHS Foundation Trust

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Alex Cumberworth, BM BS BSc

CONTACT

alex.cumberworth@me.com

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 11, 2015
• First Posted: November 13, 2015
• Study Start: December 1, 2015
• Primary Completion: August 1, 2016
• Last Updated: November 13, 2015

Record last verified: 2015-10

Locations

GB (1)