"Effect of Scaling and Root Planing on Liver Function Test (Alanine Aminotransferase and Aspartate Aminotransferase) in Systemically Healthy - Chronic Periodontitis Subjects: a Clinical Trial."

NCT02583841 | Completed Phase 4

• 1 other identifier: TatyasahebKoreDentalC
• Study Type: interventional
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Aim: To evaluate effect of non- surgical periodontal therapy on liver function in systemically healthy chronic periodontitis (CP) subjects. Materials and methods: The study is non surgical interventional trial, includes 50 CP subjects in the age group of 35- 60 years selected from the OPD (Out Patient Department) of department of periodontology Tatyasaheb Kore Dental College and Research center (TKDC and RC), Kolhapur. CP subjects were equally divided into test group and control group. Liver function test- aspartate aminotransferase (AST), alanine aminotransferase (ALT) were checked at baseline and at 1 month after treatment. Clinical examination includes plaque index, gingival index, sulcus bleeding index, probing depth, clinical attachment loss.

Conditions

Chronic Periodontitis (CP) Subjects.

Outcome Measures

Primary Outcomes (2)

• Alanine aminotransferase

  1month

• Aspartate aminotransferase

  1 month

Secondary Outcomes (5)

• plaque index

  1month

• gingival index

  1 month

• sulcus bleeding index

  1month

• probing depth

  1month

• Clinical attachment loss

  1 month

Study Arms (2)

Scaling and Root Planing( SRP)

ACTIVE COMPARATOR

This was an interventional study in which scaling and root planing was done in systemically healthy patients with chronic periodontitis

Procedure: Scaling and root planing

Control Group

NO INTERVENTION

Scaling and root planing was not done , that is no intervention is carried out in the patients of this group.

Interventions

Scaling and root planing PROCEDURE

scaling and root planing as an intervention was done in patients of the test group

Scaling and Root Planing( SRP)

Eligibility Criteria

• Age: 35 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Subjects with CP (moderate and severe) as per Centers for disease control and prevention (CDC) criteria 2007.
• Patients without any known systemic diseases

You may not qualify if:

• Patients who have taken anti-inflammatory/antibiotic/antioxidant within 3 months of beginning of study.
• Subjects who have undergone periodontal treatment within six months of inception of study.
• Smokers, tobacco habits in any form and alcoholics.
• Pregnant and lactating women.

Sponsors & Collaborators

• Tatyasaheb Kore Dental College: lead

MeSH Terms

Conditions

Chronic Periodontitis

Interventions

Tooth Exfoliation; Root Planing

Condition Hierarchy (Ancestors)

Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Dental Physiological Phenomena; Digestive System and Oral Physiological Phenomena; Dental Scaling; Dental Prophylaxis; Periodontics; Dentistry; Subgingival Curettage; Preventive Dentistry

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Post graduate student

Study Record Dates

• First Submitted: October 17, 2015
• First Posted: October 22, 2015
• Study Start: February 1, 2015
• Primary Completion: March 1, 2015
• Study Completion: March 1, 2015
• Last Updated: October 22, 2015

Record last verified: 2015-10