Phase I/II Trial of Everolimus in Combination With Lonafarnib in Progeria

NCT02579044 | Enrolling By Invitation Phase 1 DMC

• 1 other identifier: P00017505
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This is a phase I/II dose-escalation trial of everolimus in combination with lonafarnib in Hutchinson-Gilford Progeria Syndrome (HGPS) and progeroid laminopathies (henceforth "progeria"). The study will be conducted at a single clinical site utilizing the Clinical and Translational Study Unit (CTSU) at Boston Children's Hospital. Lonafarnib will be administered at doses previously established in the pediatric population and in this population of progeria subjects. This study will first determine the dose-limiting toxicities (DLT) and the maximum tolerated dose (MTD) of everolimus when administered in combination with lonafarnib. It will then determine the efficacy of everolimus when administered at its MTD in combination with lonafarnib for disease in progeria.

Conditions

Progeria

Outcome Measures

Primary Outcomes (4)

• Maximum-tolerated dose (MTD) of everolimus when administered orally in combination with lonafarnib in subjects with progeria

  For Phase I portion of protocol

  12 Months

• Number and type of dose-limiting toxicities when everolimus and lonafarnib are administered in combination to children with progeria

  For Phase I portion of protocol

  12 Months

• Annual increase in weight gain

  For Phase II portion of protocol

  24 Months

• Change in pulse wave velocity (PWV)

  For Phase II portion of protocol

  24 months

Secondary Outcomes (2)

• Markers of progeria-specific activity

  24 Months

• Trough levels of everolimus in combination with lonafarnib in progeria

  12 months

Study Arms (1)

Everolimus and Lonafarnib

OTHER

Single arm. Phase I: Lonafarnib with escalating doses of everolimus to determine MTD Phase II: Lonafarnib plus everolimus at MTD (efficacy assessment)

Drug: Everolimus and lonafarnib

Interventions

Everolimus and lonafarnib DRUG

Everolimus and Lonafarnib

Eligibility Criteria

• Age: 18 Months - 25 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Genetically-confirmed progeria.
• display clinical signs of progeria as per the clinical trial team.
• currently receiving lonafarnib under protocol 09-06-0298
• have not experienced a grade 3 or 4 toxicity within two months preceding enrollment
• willing and able to come to Boston for appropriate studies and examinations.
• no recent fractures or major surgery (within four weeks)
• Absolute poly count (Absolute neutrophil count + bands + monocytes) \>1,000/uL
• platelets \>75,000/uL (transfusion independent)
• hemoglobin \>9 g/dL
• creatinine ≤ 1.5 times upper limit of normal (ULN) for age or Glomerular filtration rate (GFR) \>70 mL/min/1.73m2
• bilirubin ≤ 1.5x upper limit of normal for age
• SGPT (ALT) \< and SGOT (AST) ≤ 2.5x normal range for age
• serum albumin greater than or equal to 2 g/dL
• PT/PTT: INR \<1.3 (or \<3 on anticoagulants)
• Fasting LDL cholesterol within 1.5x ULN per institutional guidelines (ie, \<195 mg/dL for 2 - 18 years of age, \<240 mg/dL for subjects \>18 years old)\* and Fasting serum cholesterol \<300 mg/dL (\<7.75 mmol/L)\* and Fasting triglycerides \<2.5 ULN (\<325 mg/dL for ages 2 - 18, \<400 for ages \>18)\*

You may not qualify if:

• Subjects must not be taking medications that significantly affect the metabolism of lonafarnib
• Subjects receiving chronic, systemic treatment with corticosteroids or another immunosuppressive agent. Subjects with endocrine deficiencies are allowed to receive physiologic or stress doses of steroids if necessary. Topical or inhaled steroids are allowed.
• Subjects who have had a major surgery or significant traumatic injury within 4 weeks of start of study drug; have not recovered from the side effects of any major surgery (defined as requiring general anesthesia but excluding a procedure for insertion of central venous access); or who may require major surgery during the course of the study.
• Subjects with an active bleeding diathesis or on oral anti-vitamin K medication (except low dose coumadin).
• Subjects who have any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study such as:
• known severely impaired lung function
• active (acute or chronic) or uncontrolled severe infections.
• liver disease such as cirrhosis, chronic active hepatitis or chronic persistent hepatitis.
• History of hepatitis B or hepatitis C
• Other concurrent severe and/or uncontrolled medical disease that could compromise participation in the study (i.e., uncontrolled diabetes, uncontrolled hypertension, severe infection, severe malnutrition, chronic liver or renal disease, active upper GI tract ulceration).
• A known history of Human Immunodeficiency Virus (HIV) seropositivity or known immunodeficiency.
• Impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of everolimus (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or small bowel resection). A nasogastric tube (NG tube) or gastric tube (G tube) is allowed.
• Subjects who have known or suspected hypersensitivity to any of the excipients included in the formulation should not be treated.
• Subjects must not be pregnant or breast-feeding. Female subjects of childbearing potential must have negative serum or urine pregnancy test. Sexually active male and female subjects of reproductive potential must agree to use a medically accepted form of birth control while on study and up to 10 weeks after treatment. It is permissible for female subjects to take oral contraceptives or other hormonal methods while receiving treatment with everolimus.

Sponsors & Collaborators

• Boston Children's Hospital: lead

Study Sites (1)

Boston Children's Hospital

Boston, Massachusetts, 02115, United States

Location

MeSH Terms

Conditions

Progeria

Interventions

Everolimus; lonafarnib

Condition Hierarchy (Ancestors)

Laminopathies; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Metabolism, Inborn Errors; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Sirolimus; Macrolides; Lactones; Organic Chemicals

Study Officials

• Monica Kleinman, M.D.

  Boston Children's Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Director, Transport & MSICU

Study Record Dates

• First Submitted: October 13, 2015
• First Posted: October 19, 2015
• Study Start: December 1, 2015
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): March 1, 2027
• Last Updated: April 2, 2026

Record last verified: 2026-03

Locations

US (1)