Brain Activity in Adults With ADHD During Neuropsychological Tasks
Brain Activity and Functional Connectivity in Adults With Attention-Deficit Hyperactivity Disorder (ADHD) During Tasks of Motor Inhibition and Cognitive Switching
1 other identifier
observational
45
1 country
1
Brief Summary
The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Aug 2015
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2015
CompletedFirst Submitted
Initial submission to the registry
August 3, 2015
CompletedFirst Posted
Study publicly available on registry
October 16, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2020
CompletedApril 7, 2022
April 1, 2022
4.8 years
August 3, 2015
April 6, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Changes in blood oxygenation level dependency (BOLD)
The study consist solely of one MRI examination performed within 2 hours.
2 hours
Study Arms (3)
Healthy volunteers
healthy volunteer between age of 20 to 55 will undergo MRI examination.
ADHD subjects without medication
Medication-naive subjects with ADHD (20-55 years) will undergo MRI examination.
ADHD subjects with medication
Subjects with ADHD (20-55 years), under medication will undergo MRI examination.
Interventions
Functional Magnetic Resonance Imaging technique measures brain activity by detecting associated changes in blood oxygenation level dependency
Eligibility Criteria
Three groups: 1. healthy volunteers 2. ADHD subjects receiving medications 3. medication-naive ADHD subjects
You may qualify if:
- Participant is between 20-55 years old
- Participant is not pregnant
You may not qualify if:
- Participant is not able to consent him/herself
- Suspected or proven pregnancy
- Nursing
- Neurological diseases that could interfere with a diagnosis of ADHD
- Psychiatric comorbidity under treatment
- Previous history of psychiatric medication
- Substance abuse
- Intelligence quotient\<75
- Claustrophobia
- Electrical simulator nerve or bone
- Implanted medication infusion pump
- Cerebral aneurysm clips
- Unstable medical condition
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Kantonsspital Aarau
Aarau, Canton of Aargau, 5001, Switzerland
Related Publications (1)
Berberat J, Huggenberger R, Montali M, Gruber P, Pircher A, Lovblad KO, Killer HE, Remonda L. Brain activation patterns in medicated versus medication-naive adults with attention-deficit hyperactivity disorder during fMRI tasks of motor inhibition and cognitive switching. BMC Med Imaging. 2021 Mar 19;21(1):53. doi: 10.1186/s12880-021-00579-3.
PMID: 33740903DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Prof. Dr. med.
Study Record Dates
First Submitted
August 3, 2015
First Posted
October 16, 2015
Study Start
August 1, 2015
Primary Completion
May 1, 2020
Study Completion
November 1, 2020
Last Updated
April 7, 2022
Record last verified: 2022-04