NCT02576769|Unknown
The Role of Melanocyte in Basal Cell Carcinoma
Melanocyte Features and Its Influence in Pigmentation in Basal Cell Carcinoma in the Mexican Population
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Melanocyte Features and Its Influence in Pigmentation in Basal Cell Carcinoma in the Mexican Population
Sponsor study identifier
observational
30
1 country
1
Study Start
November 2015
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
November 2016
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 2016
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Basal cell carcinoma (BCC) is the most frequent neoplasia worldwide. There are more than 30 histopathologic subtypes, however the nodular subtype is the most common. Pigmented varieties are common in darker skin types, therefore in our country. Previous studies have shown an increase number and size of melanocytes. Melanogenesis were increased at the expense of hyperfunctioning melanocytes as well. The aim of the study was to describe the characteristics of melanocytes in pigmented and non-pigmented variants of basal cell carcinoma.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2016
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 13, 2015
Actual (reported)October 15, 2015
Actual (reported)November 2015
Date type not reportedThis date has not been verified as actual or estimated.
November 2016
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 2016
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Melanocyte number
To quantify the number of melanocytes in basal cell carcinoma
Up to 1 year
Melanocyte phenotype
To quantify melanocyte maturation stages in basal cell carcinoma through markers
Up to 1 year
Melanogenesis characteristics
To quantify the expression of melanogenic markers in basal cell carcinoma
Up to 1 year
Melanin presence
Up to 1 year
Vessels number (angiogenesis)
Up to 1 year
Mast cells number
Up to 1 year
Solar elastosis quantity
Up to 1 year
Basal cell carcinoma
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Patients with histologic diagnosis of basal cell carcinoma
Hospital Central Dr. Ignacio Morones Prieto
San Luis Potosí City, San Luis Potosí, 78210, Mexico
Lao LM, Kumakiri M, Kiyohara T, Kuwahara H, Ueda K. Sub-populations of melanocytes in pigmented basal cell carcinoma: a quantitative, ultrastructural investigation. J Cutan Pathol. 2001 Jan;28(1):34-43. doi: 10.1034/j.1600-0560.2001.280104.x.
Sakuraba K, Hayashi N, Kawashima M, Imokawa G. Down-regulated PAR-2 is associated in part with interrupted melanosome transfer in pigmented basal cell epithelioma. Pigment Cell Res. 2004 Aug;17(4):371-8. doi: 10.1111/j.1600-0749.2004.00156.x.
Juan P Castanedo-Cazares, MD, MSc
Hospital Central "Dr. Ignacio Morones Prieto"
Bertha Torres-Alvarez, MD
Hospital Central "Dr. Ignacio Morones Prieto"
First Submitted
October 13, 2015
First Posted
October 15, 2015
Study Start
November 2015
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
November 2016
Early Detection of Skin Cancer With Sensor Technology
Contact the study team to confirm eligibility.
Frey LM, Houben R, Brocker EB. Pigmentation, Melanocyte Colonization, and p53 Status in Basal Cell Carcinoma. J Skin Cancer. 2011;2011:349726. doi: 10.1155/2011/349726. Epub 2010 Sep 29.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 2016
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
October 15, 2015
Record last verified: 2015-10
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Source: ClinicalTrials.gov.
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