MELA Study - Hedonic Study on the Taste of Drugs Crushed in Food: Observational Study Involving 16 Healthy Volunteers

NCT02570581 | Completed Phase 1

• 1 other identifier: 2013-003461-34
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

Elderly people often suffer from chronic pathologies and they are given polypharmacy. In case of swallowing problems, the drugs are crushed and mixed in food, which alters the taste of food and is a cause of anorexia and malnutrition. Gustative side-effects of crushed drugs have nether been investigated. The MELA study is a one session hedonic test involving 16 healthy volunteers. They will score in a blind manner the taste of 10 drugs commonly prescribed in nursing homes, crushed in jelly or apple compote. These volunteers will be 8 food professionals and 8 geriatric care professionals. Thanks to the MELA protocol, they will have a unique opportunity to communicate and propose solutions to this neglected aspect of malnutrition in elderly populations.

Conditions

Healthy

Keywords

volonteeres

Outcome Measures

Primary Outcomes (1)

• Quantitative- compare the taste between specimens

  Quantitative: mark from 0 (bad taste) to 10 (no taste or no unpleasant taste) for the jelly and compote specimens added with crushed drugs.

  1 week after the test

Secondary Outcomes (1)

• qualitative - description of the perceived aroma

  1 week after the test

Study Arms (24)

Plain jelly control

PLACEBO COMPARATOR

Plain jelly control

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

Jelly with: Paracetamol

ACTIVE COMPARATOR

Jelly with: Paracetamol

Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

Jelly with Furosemide

ACTIVE COMPARATOR

Jelly with Furosemide

Other: Jelly with:Paracetamol; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

Jelly with Levothyroxine sodium salt

ACTIVE COMPARATOR

Jelly with Levothyroxine sodium salt

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

Jelly with memantine

ACTIVE COMPARATOR

Jelly with memantine

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

jelly with zopiclone

ACTIVE COMPARATOR

Jelly with zopiclone

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

jelly with alprazolam

ACTIVE COMPARATOR

elly with alprazolam

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

jelly with Oxazepam

ACTIVE COMPARATOR

Jelly with Oxazepam

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

jelly with donepezil

ACTIVE COMPARATOR

jelly with donepezil

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

Jelly with clopidogrel

ACTIVE COMPARATOR

jelly with clopidogrel

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

jelly with ramipril

ACTIVE COMPARATOR

jelly with ramipril

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

jelly with Paracetamol + Furosemide + Levothyroxine sodium sa

ACTIVE COMPARATOR

Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

Plain apple compote control

PLACEBO COMPARATOR

Plain apple compote control

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam

Apple compote Paracetamol

ACTIVE COMPARATOR

Apple compote Paracetamol

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

Apple compote Furosemide

ACTIVE COMPARATOR

Apple compote Furosemide

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

Apple compote Levothyroxine sodium salt

ACTIVE COMPARATOR

Apple compote Levothyroxine sodium salt

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

Apple compote Memantine

ACTIVE COMPARATOR

Apple compote Memantine

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

Apple compote Zopiclone

ACTIVE COMPARATOR

Apple compote Zopiclone

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

Apple compote Alprazolam

ACTIVE COMPARATOR

Apple compote Alprazolam

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

Apple compote Oxazepam

ACTIVE COMPARATOR

Apple compote Oxazepam

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

Apple compote Donepezil

ACTIVE COMPARATOR

Apple compote Donepezil

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

Apple compote Clopidogrel

ACTIVE COMPARATOR

Apple compote Clopidogrel

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Ramipril; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

Apple compote Ramipril

ACTIVE COMPARATOR

Apple compote Ramipril

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain apple compote control

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi

ACTIVE COMPARATOR

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopiclone Alprazolam

Other: Jelly with:Paracetamol; Other: Jelly with Furosemide; Other: Jelly with Levothyroxine sodium salt; Other: Jelly with Memantine; Other: Jelly with Zopiclone; Other: Jelly with Alprazolam; Other: Jelly with Oxazepam; Other: Jelly with Donepezil; Other: Jelly with Clopidogrel; Other: Jelly with Ramipril; Other: Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam; Other: Plain jelly control; Other: Apple compote Paracetamol; Other: Apple compote Furosemide; Other: Apple compote Levothyroxine sodium salt; Other: Apple compote Memantine; Other: Apple compote Zopiclone; Other: Apple compote Alprazolam; Other: Apple compote Oxazepam; Other: Apple compote Donepezil; Other: Apple compote Clopidogrel; Other: Apple compote Ramipril; Other: Plain apple compote control

Interventions

Jelly with:Paracetamol OTHER

A single dose of each drug will be opened (Paracetamol capsule) or crushed (tablets) in 100 ml of jelly (intervention 1-10) and in 100 ml of apple compote A mix of 6 drugs will be added to 100 ml of jelly (intervention 11) and in 100 ml of apple compote A negative control will consists in 100 ml of plain jelly or apple compote Each participant will receive 24 small transparent plastic glasses ("verrines") randomly allocated from number 1 to number 24, each verrine containing 5 ml of the initial 100 ml drug preparation. The participant will be blind to the verrine content. The participant will taste the verrine content with a 1 ml spoon and spit out each spoonful et rinse his or her mouth with plain water (Evian) between two tests. The participant will score each verrine numbered 1-24 with a mark ranging from 0 to 10 on the results scoring sheet. Unblinding will take place immediately after the end of the test. Every volunteer will propose alternative solutions.

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Jelly with Furosemide OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Jelly with Levothyroxine sodium salt OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Jelly with Memantine OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Jelly with Zopiclone OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril

Jelly with Alprazolam OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Jelly with Oxazepam OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Jelly with Donepezil OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with ramipril; jelly with zopiclone

Jelly with Clopidogrel OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Jelly with Ramipril OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with zopiclone

Jelly with Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Plain jelly control OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Apple compote Paracetamol OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Apple compote Furosemide OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Apple compote Levothyroxine sodium salt OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Apple compote Memantine OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Apple compote Zopiclone OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Apple compote Alprazolam OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Apple compote Oxazepam OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Apple compote Donepezil OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Apple compote Clopidogrel OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Apple compote Ramipril OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Apple compote + Paracetamol + Furosemide + Levothyroxine sodium salt + Memantine + Zopiclone + Alprazolam OTHER

Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain apple compote control; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Plain apple compote control OTHER

Apple Paracetamol Furosemide Levothyroxine NACL Memantine Zopi; Apple compote Alprazolam; Apple compote Clopidogrel; Apple compote Donepezil; Apple compote Furosemide; Apple compote Levothyroxine sodium salt; Apple compote Memantine; Apple compote Oxazepam; Apple compote Paracetamol; Apple compote Ramipril; Apple compote Zopiclone; Jelly with Furosemide; Jelly with Levothyroxine sodium salt; Jelly with clopidogrel; Jelly with memantine; Jelly with: Paracetamol; Plain jelly control; jelly with Oxazepam; jelly with Paracetamol + Furosemide + Levothyroxine sodium sa; jelly with alprazolam; jelly with donepezil; jelly with ramipril; jelly with zopiclone

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• healthy volunteers over 18 years.

You may not qualify if:

• pregnant women. Women in age to borne children will perform a urinary test will just before the assay, under the supervision of the Clinical Research Center nurse.

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nice: lead

Study Sites (1)

Center for Clinical Research - Archet 1 Hospital Nice Hospital

Nice, 06200, France

Location

MeSH Terms

Interventions

Gels; Furosemide; Memantine; zopiclone; Alprazolam; Oxazepam; Donepezil; Clopidogrel; Ramipril; Acetaminophen

Intervention Hierarchy (Ancestors)

Colloids; Complex Mixtures; Dosage Forms; Pharmaceutical Preparations; Sulfanilamides; Sulfonamides; Amides; Organic Chemicals; Aniline Compounds; Amines; Sulfones; Sulfur Compounds; Amantadine; Adamantane; Bridged-Ring Compounds; Hydrocarbons, Cyclic; Hydrocarbons; Benzodiazepines; Benzazepines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds; Benzodiazepinones; Indans; Indenes; Polycyclic Aromatic Hydrocarbons; Hydrocarbons, Aromatic; Piperidines; Heterocyclic Compounds, 1-Ring; Polycyclic Compounds; Ticlopidine; Thienopyridines; Thiophenes; Pyridines; Acetanilides; Anilides

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 29, 2015
• First Posted: October 7, 2015
• Study Start: June 1, 2014
• Primary Completion: July 1, 2014
• Study Completion: July 1, 2014
• Last Updated: October 7, 2015

Record last verified: 2015-09

Locations

FR (1)