Immunoregulation of Periodontal Diseases

NCT02567019 | Unknown

• 1 other identifier: 2015-A00882-47
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Periodontal diseases are a group of diseases that affect 15% of the population and in the absence of treatment causes tooth loss. Periodontal lesions are characterized mainly by strong inflammation and hyper-vascularization. Search in blood cells and inflammatory markers attempts to explain the etiological-pathogenetic mechanisms. Innate immunity can be assessed by qualitative and quantitative analysis of blood phagocytes, natural killer cells, complement, proteins of inflammation and cytokines. Current data from the literature on this subject give contradictory results and the comparison of studies are difficult because the diversity of the populations studied, evaluated cells and the methods used. The aim of the study was to evaluate the innate immunity of patients with periodontal disease and compare it with a group of patients without periodontal disease.

Conditions

Parodontosis

Outcome Measures

Primary Outcomes (1)

• % phagocytes cells of blood

  Identification of altered immunological parameters in patients with periodontal disease

  1 year

Study Arms (2)

periodontal diseases

EXPERIMENTAL

blood samples will be done for patients suffering of periodontal diseases

Other: blood samples

healthy volunteers

ACTIVE COMPARATOR

blood samples will be done for healthy volunteers

Other: blood samples

Interventions

blood samples OTHER

blood samples will be done for patients patients suffering of periodontal diseases and healthy volunteers

healthy volunteers; periodontal diseases

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• For periodontal subjects
• At least present 20 teeth on the dental arches
• Presence of periodontal deep pockets = 4 mm measured by means of a periodontal probe increased in millimeters and raised on at least 30 % of the dental surfaces (proximal, vestibular and Palatine or lingual) present teeth on the dental arches.
• For healthy volunteers : absence of periodontal deep pockets

You may not qualify if:

• pathologies or treatments whom could affect the immunological parameters for the both arms

Sponsors & Collaborators

• Assistance Publique Hopitaux De Marseille: lead

Study Sites (1)

Assistance Publique Hopitaux de Marseille

Marseille, 13005, France

RECRUITING

MeSH Terms

Conditions

Periodontal Diseases

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Virgine MONNET CORTI

  Assistance Publique Hopitaux De Marseille

  PRINCIPAL INVESTIGATOR

Central Study Contacts

virginie MONNET CORTI

CONTACT

vmonnet-corti@ap-hm.fr

Alexandra GIULIANI

CONTACT

0491382870; agiuliani@ap-hm.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 31, 2015
• First Posted: October 2, 2015
• Study Start: December 1, 2015
• Primary Completion: September 1, 2016
• Study Completion: December 1, 2016
• Last Updated: July 7, 2016

Record last verified: 2016-07

Locations

FR (1)