Effects of the Visual Stimulation on the Motor and Visual Cortex in Migraneurs With and Without Aura

NCT02564822 | Completed DMC

• 1 other identifier: VisualStimulation_Migraine
• Study Type: observational
• Target: 59
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to investigate the motor and visual cortex excitability in response to visual stimulation of migraineurs with and without aura compared to healthy individuals. For this purpose, electrical cortical activity of migraineurs will be compared to healthy volunteers.

Conditions

Migraine Disorders

Keywords

migraine disorders; cortical excitability; transcranial magnetic stimulation; electroencephalography

Outcome Measures

Primary Outcomes (1)

• Changes on motor evoked potentials

  to measure MEP, the intensity of the magnetic stimulator will be adjusted to 120% of rest motor threshold and 10 stimuli will be registered. For evaluation volunteers will be instructed to sit in a chair and get into a comfortable position. Initially, single-pulse TMS will be administered over the motor cortex to determine the cortical representation area of the first dorsal interosseous muscle (FDI). For all evaluations the same figure-eight coil is used, in order to avoid measurement bias. Amplitude means of evoked potentials will determine the MEP.

  one day (Before and after visual stimulation)

Secondary Outcomes (4)

• Changes on short interval intracortical inhibition

  one day (Before and after visual stimulation)

• Changes on intracortical facilitation

  one day (Before and after visual stimulation)

• Changes from phosphene threshold

  one day (Before and after visual stimulation)

• Habituation of Visual Evoked Potentials evaluated by Electroencephalography

  one day (during visual stimulation)

Study Arms (2)

Migraneurs - Visual stimulation

Patients will be recruited via advertisements on the university. Patients should have migraine diagnosis according to the International Classification of Headache Disorders (ICHD-III) criteria and clinical diagnosis by a neurologist.

Procedure: Visual Stimulation

Control - Visual stimulation

Healthy volunteers will be recruited via advertisements on the university. For control subjects the individuals should not have migraine diagnosis assessed according to IHCD-III criteria.

Procedure: Visual Stimulation

Interventions

Visual Stimulation PROCEDURE

volunteers will be invited to sit in a comfortable chair, in a calm and dark room, at 90 cm of distance from computer screen. It will be asked to fix his right eye visual field on a red point at the center of the screen (the left one will be blindfolded). Visual stimuli will be a black and White grid pattern, alternating at a frequency of 3.1 Hz.

Control - Visual stimulation; Migraneurs - Visual stimulation

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients and healthy volunteers will be recruited via advertisements on the university. Patients should have migraine diagnosis according to the International Classification of Headache Disorders (ICHD-III) criteria and clinical diagnosis by a neurologist. For control subjects the individuals should not have migraine diagnosis assessed according to IHCD-III criteria.

You may qualify if:

• Ages: 18-55 years
• Gender: Both
• Prior headache report

You may not qualify if:

• Pregnant women;
• Pacemaker;
• History of seizures;
• Metallic implants in the head;
• Patients with clinical evidence of brain injuries;
• Chronic pain associated to others diseases;
• Use of neuroleptic medications

Sponsors & Collaborators

• Universidade Federal de Pernambuco: lead

Study Sites (1)

Laboratório de Neurociência Aplicada (LANA)

Recife, Pernambuco, 50670-901, Brazil

Location

MeSH Terms

Conditions

Migraine Disorders

Interventions

Photic Stimulation

Condition Hierarchy (Ancestors)

Headache Disorders, Primary; Headache Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Physical Stimulation; Investigative Techniques

Study Officials

• Kátia Monte-Silva, PhD

  Universidade Federal de Pernambuco

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 22, 2015
• First Posted: October 1, 2015
• Study Start: July 1, 2015
• Primary Completion: June 1, 2016
• Study Completion: August 1, 2016
• Last Updated: August 24, 2018

Record last verified: 2018-08

Locations

BR (1)