NCT02563223

Brief Summary

In this project, investigators propose to study the jump in different reduced gravity fields obtained during parabolic flights profiles but also during increased gravity fields obtained during turns of the airplane or during the pull-up phase of the parabola. By means of a pneumatic device, an additional pull-down force will be added to the vertical force caused by the gravity field. By combining different levels of gravity to different levels of the added pull-down force it will be possible to dissociate the respective contribution of the otolithic and proprioceptive systems to the anticipatory landing response. To the investigators' knowledge, only one study has modified the gravity field during a jump. However, these authors did not add a pull-down force and only analyzed the vertical ground reaction force. A better knowledge of the sensory-motor control of the landing phase of a jump will also increase the investigators' understanding of the physiopathology of joint instability. Indeed, similarities could be found between the evolution of the motor response due to the absence gravity during long-duration space flights and the pathological process of chronic ankle and knee instability. The knowledge generated by this study will thus provide invaluable information in the context of human performance and rehabilitation.

Trial Health

55
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
18

participants targeted

Target at below P25 for not_applicable healthy-volunteers

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2011

Completed
3.7 years until next milestone

First Submitted

Initial submission to the registry

July 23, 2015

Completed
2 months until next milestone

First Posted

Study publicly available on registry

September 30, 2015

Completed
1 day until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2015

Completed
Last Updated

September 30, 2015

Status Verified

September 1, 2015

Enrollment Period

3.9 years

First QC Date

July 23, 2015

Last Update Submit

September 28, 2015

Conditions

Outcome Measures

Primary Outcomes (1)

  • Electromyography (Amplitude - mV and latency - ms)

    EMG (electrical activity produced my muscles when they contract) will be recorded with a MyoSystem 1400L using surface electrodes at the level of the lateral gastrocnemius, medial gastrocnemius, tibialis anterior and peroneus longus, and on the thigh at the level of the vastus lateralis, vastus medialis and lateral hamstrings and medial hamstrings. EMG activation (amplitude and latency) will be measured during jumps at different level of gravity and pull-down forces.

    baseline

Study Arms (1)

electromyographic (EMG) measurements

OTHER

Interaction between gravity (weightlessness, hypergravity, and normal gravity) and pull-down force ont EMG amplitude and EMG timing.

Other: Parabolic flightDevice: Subject Loading System

Interventions

electromyographic (EMG) measurements

a device that combines a force platform on which the subject jumps and a Subject Loading System (SLS) that pulls the subject downwards.

electromyographic (EMG) measurements

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Healthy volunteers (men or women)
  • Aged from 18 to 65
  • Affiliated to a Social Security system and, for non-French resident, holding a European Health Insurance Card (EHIC)
  • Who accepted to take part in the study
  • Who have given their written stated consent
  • Who has passed a medical examination similar to a standard aviation medical examination for private pilot aptitude. There will be no additional test performed for subject selection

You may not qualify if:

  • Pregnant women
  • Person with medical history of musculoskeletal disorders of the lower limbs, pelvis or spine, neurological or vestibular disorders.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Umr Ucbn/Inserm U1075 Comete

Caen, Basse-Normandie, 14032, France

RECRUITING

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 23, 2015

First Posted

September 30, 2015

Study Start

November 1, 2011

Primary Completion

October 1, 2015

Last Updated

September 30, 2015

Record last verified: 2015-09

Locations