Effect of Resistance Training on Metabolic Control and Outcome in Prediabetes (NMR-based Metabonomics)
1 other identifier
interventional
276
1 country
2
Brief Summary
This study evaluates the efficacy of a 12-month resistance training on metabolic control and reducing the risk of diabetes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Sep 2015
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2015
CompletedFirst Submitted
Initial submission to the registry
September 24, 2015
CompletedFirst Posted
Study publicly available on registry
September 28, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2016
CompletedSeptember 29, 2015
September 1, 2015
10 months
September 24, 2015
September 28, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
glycemic control
Fasting blood glucose, postprandial blood glucose and HbA1c will be measured at 6 months.
6 months
glycemic control
Fasting blood glucose, postprandial blood glucose and HbA1c will be measured at 12 months.
12 months
Secondary Outcomes (4)
small molecule metabolites
6 months
small molecule metabolites
12 months
Incidence rate of diabetes
6 months
Incidence rate of diabetes
12 months
Study Arms (3)
resistance training
EXPERIMENTALResistance training consisted of 6 different resistance exercises per session using elastic string, and each exercise progressed to 2-3 at maximum resistance lifted 8-10 times.
aerobic training
EXPERIMENTALAerobic training consisted of aerobic exercise and progressed from 15-20min/session at 60% maximum heart rate to 45-50min/session at 75% maximum heart rate.
standard care
NO INTERVENTIONstandard care complied with the daily lifestyle.
Interventions
Resistance training consisted of 6 different resistance exercises per session using elastic string, and each exercise progressed to 2-3 at maximum resistance lifted 8-10 times.
Aerobic training consisted of aerobic exercise and progressed from 15-20min/session at 60% maximum heart rate to 45-50min/session at 75% maximum heart rate.
Eligibility Criteria
You may qualify if:
- a confirmed diagnosis of prediabetes according to the American Diabetes Association (ADA) guidelines
- level 4 of muscle strength
- willingness to accept exercise intervention
- provision of written informed consent.
You may not qualify if:
- type 2 or other types of diabetes
- women who are pregnant
- hepatic dysfunction, as evidenced by alanine aminotransferase (ALT) or alkaline phosphatase (ALP) levels greater than 2.5-fold the upper limits of normal
- crucial organ failure or other severe diseases, including myocardial infarction
- malignancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Nanjing University of Traditional Chinese Medicinelead
- Guangxi Medical Universitycollaborator
- Southeast University, Chinacollaborator
Study Sites (2)
The first Affiliated hospital of Guangxi medical university
Nanning, Guangxi, 530021, China
Southeast University, China
Nanjing, Jiangsu, 210096, China
Related Publications (5)
Morrison F, Shubina M, Turchin A. Lifestyle counseling in routine care and long-term glucose, blood pressure, and cholesterol control in patients with diabetes. Diabetes Care. 2012 Feb;35(2):334-41. doi: 10.2337/dc11-1635.
PMID: 22275442BACKGROUNDLewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, Gerszten RE. Metabolic signatures of exercise in human plasma. Sci Transl Med. 2010 May 26;2(33):33ra37. doi: 10.1126/scitranslmed.3001006.
PMID: 20505214BACKGROUNDStrasser B, Siebert U, Schobersberger W. Resistance training in the treatment of the metabolic syndrome: a systematic review and meta-analysis of the effect of resistance training on metabolic clustering in patients with abnormal glucose metabolism. Sports Med. 2010 May 1;40(5):397-415. doi: 10.2165/11531380-000000000-00000.
PMID: 20433212BACKGROUNDChen X, Zhao S, Hsue C, Dai X, Liu L, Miller JD, Fang Z, Feng J, Huang Y, Wang X, Lou Q. Effects of aerobic training and resistance training in reducing cardiovascular disease risk for patients with prediabetes: A multi-center randomized controlled trial. Prim Care Diabetes. 2021 Dec;15(6):1063-1070. doi: 10.1016/j.pcd.2021.08.013. Epub 2021 Oct 11.
PMID: 34649825DERIVEDYan J, Dai X, Feng J, Yuan X, Li J, Yang L, Zuo P, Fang Z, Liu C, Hsue C, Zhu J, Miller JD, Lou Q. Effect of 12-Month Resistance Training on Changes in Abdominal Adipose Tissue and Metabolic Variables in Patients with Prediabetes: A Randomized Controlled Trial. J Diabetes Res. 2019 Oct 16;2019:8469739. doi: 10.1155/2019/8469739. eCollection 2019.
PMID: 31737686DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Qingqing Lou
Nanjing University of Traditional Chinese Medicine
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- director, department of education
Study Record Dates
First Submitted
September 24, 2015
First Posted
September 28, 2015
Study Start
September 1, 2015
Primary Completion
July 1, 2016
Study Completion
September 1, 2016
Last Updated
September 29, 2015
Record last verified: 2015-09