NCT02555865

Brief Summary

This multicenter retrospective observation study is designed to investigate the etiology of children with bronchiectasis by review the medical records.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
300

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jun 2016

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 14, 2015

Completed
8 days until next milestone

First Posted

Study publicly available on registry

September 22, 2015

Completed
8 months until next milestone

Study Start

First participant enrolled

June 1, 2016

Completed
5.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2022

Completed
Last Updated

January 9, 2017

Status Verified

January 1, 2017

Enrollment Period

5.8 years

First QC Date

September 14, 2015

Last Update Submit

January 6, 2017

Conditions

Bronchiectasis

Keywords

etiologychildren

Outcome Measures

Primary Outcomes (1)

  • Number of participants with differential causes of bronchiectasis by reviewing the medical records or undergoing the standard diagnostic process

    The cause of each paticipant with bronchiectasis will be recorded, for example post infection, PCD, PID, et al.

    48 months

Eligibility Criteria

AgeUp to 18 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Children who was confirmed diagnosis as bronchiectasis at the certain hospitals (sponsor and collaborators)

You may qualify if:

  • Internal bronchial diameter greater than the accompanying pulmonary artery.
  • lack of bronchial tapering
  • bronchi visible in the peripheral 1cm of lung
  • bronchial diameter greater than adjacent segmental bronchi

You may not qualify if:

  • It is unable to provide complete medical records or the current condition can not accept the diagnosis process
  • It does not agree to participate in the test

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Beijing Children'S Hospital

Beijing, Beijing Municipality, 100045, China

RECRUITING

Related Publications (8)

  • Barker AF. Bronchiectasis. N Engl J Med. 2002 May 2;346(18):1383-93. doi: 10.1056/NEJMra012519. No abstract available.

    PMID: 11986413BACKGROUND

  • Amorim A, Gracia Roldan J. Bronchiectasis: do we need aetiological investigation? Rev Port Pneumol. 2011 Jan-Feb;17(1):32-40. English, Portuguese.

    PMID: 21251482BACKGROUND

  • Gaillard EA, Carty H, Heaf D, Smyth RL. Reversible bronchial dilatation in children: comparison of serial high-resolution computer tomography scans of the lungs. Eur J Radiol. 2003 Sep;47(3):215-20. doi: 10.1016/s0720-048x(02)00122-5.

    PMID: 12927665BACKGROUND

  • Eastham KM, Fall AJ, Mitchell L, Spencer DA. The need to redefine non-cystic fibrosis bronchiectasis in childhood. Thorax. 2004 Apr;59(4):324-7. doi: 10.1136/thx.2003.011577.

    PMID: 15047953BACKGROUND

  • Brower KS, Del Vecchio MT, Aronoff SC. The etiologies of non-CF bronchiectasis in childhood: a systematic review of 989 subjects. BMC Pediatr. 2014 Dec 10;14:4. doi: 10.1186/s12887-014-0299-y.

    PMID: 25492164BACKGROUND

  • LIU Xiu-yun, JIANG Zai-fang. The etiology of ninety-one children with bronchiecatsis. J Clin Pediatr, 2011, 29(2):127-129.

    BACKGROUND

  • CHEN Jun, DUO Li-kun, WANG Xiao-feng. Clinical analysis of 22 children with bronchiectasis. J Clin Pediatr, 2012, 30(1):51-54.

    BACKGROUND

  • WANG Hao，XU Bao-ping，LIU Xiu-yun，HU Ying-hui，REN Yi-xin，SHEN Kun-ling. Clinical characteristics and follow-up of bronchiectasis in children. Chinese Journal of Practical Pediatrics, 2014;29 (12):936-939.

    BACKGROUND

MeSH Terms

Conditions

Bronchiectasis

Condition Hierarchy (Ancestors)

Bronchial DiseasesRespiratory Tract Diseases

Study Officials

  • Kunling Shen, MD,PhD

    Beijing Children's Hospital of Capital Medical University, China

    STUDY DIRECTOR

  • Baoping Xu, MD,PhD

    Beijing Children's Hospital of Capital Medical University, China

    PRINCIPAL INVESTIGATOR

  • Xiaoxia Peng, MD,PhD

    Beijing Children's Hospital of Capital Medical University, China

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Baoping Xu, MD,PhD

CONTACT

861059616308xubaopingbch@163.com

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Chief of Respiratory Department

Study Record Dates

First Submitted

September 14, 2015

First Posted

September 22, 2015

Study Start

June 1, 2016

Primary Completion

March 1, 2022

Study Completion

March 1, 2022

Last Updated

January 9, 2017

Record last verified: 2017-01

Locations

CN(1)