Molecular Mechanisms of Senescence Predisposing to Cancer : Exploratory Analysis on Healthy Tissues (SkinAge).

NCT02553954 | Completed

• 2 other identifiers: SkinAge-13062013-A01793-42
• Study Type: interventional
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

Epidemiological data show that the incidence of carcinoma, the most common cancer, is strongly linked to the age. Non Melanoma Skin Carcinomas (NMSCs) (the most frequent cancers in the elderly population) derive from keratinocytes of the basal layer of the epidermis, from differentiated keratinocytes of the more superficial layers or from stem cells of hair follicles. Unlike NMSCs, soft-tissue sarcomas, including those deriving from dermal fibroblasts, are very rare (less than 1% of all cancers). Our overall purpose is to decipher the molecular pathways activated during the aging of these tissues that may explain why they have a so different propensity to undergo a malignant transformation. Given that senescent cells accumulate in the dermis and epidermis with age, we will constitute two groups : "young skin" that we arbitrarily limit to the range ≥ 18 and ≤ 40 and "aged skin" ≥ 55. Thus the main objective of our study is to search within 2 age groups (≥ 18 and ≤ 40 years and ≥ 55 years) the expression of senescence markers on healthy skin tissue.

Conditions

Sarcoma

Keywords

Mechanisms of Senescence; Senescence markers

Outcome Measures

Primary Outcomes (1)

• Expression of senescence markers in healthy skin tissues collected for the two age groups.

  Baseline

Secondary Outcomes (3)

• Research of emerging cells in the skin tissue of the subjects of the two age groups via the expression of the Protease-Activated Receptor-1 (PAR-1).

  Baseline

• Presence of different types of DNA damage (single and double strand breaks) in the keratinocytes and fibroblasts of the skin tissues of the two age groups.

  Baseline

• Morbidity

  Baseline

Study Arms (1)

Collection of healthy skin tissue

EXPERIMENTAL

Collection of healthy skin tissue

Procedure: Collection of healthy skin tissue

Interventions

Collection of healthy skin tissue PROCEDURE

Collection of two samples of healthy skin tissue, without disfigurement, during an intervention under general anesthesia for the treatment of a benign or malignant tumor.

Collection of healthy skin tissue

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient with an operable sarcoma
• Requiring a surgical operation under general anesthesia at the Oscar Lambret Centre
• Age ≥ 18 ans, belonging to one of the two following age groups : \[ ≥ 18 and ≤ 40 years\] and \[ ≥ 55 years\]
• Patient having a social security scheme
• Patient having signed an informed consent form for the study

You may not qualify if:

• Patient aged under 18 or between 41 and 54
• Location of the tumor on the face, neck or neckline
• Patient with a skin tumor
• Tumor-induced cutaneous fistula making suspect a tumor invasion of the skin
• Patient with a chronic skin disease
• Collection in an area already treated by surgery, radiotherapy or brachytherapy
• Pregnant or breastfeeding women
• Patient under guardianship or tutorship

Sponsors & Collaborators

• Centre Oscar Lambret: lead
• Institut de Biologie de Lille: collaborator

Study Sites (1)

Centre Oscar Lambret

Lille, 59020, France

Location

MeSH Terms

Conditions

Sarcoma

Condition Hierarchy (Ancestors)

Neoplasms, Connective and Soft Tissue; Neoplasms by Histologic Type; Neoplasms

Study Officials

• Nicolas PENEL, MD

  Centre Oscar Lambret

  STUDY CHAIR

• Olivier PLUQUET

  Institut de Biologie de Lille

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 17, 2015
• First Posted: September 18, 2015
• Study Start: October 7, 2014
• Primary Completion: April 16, 2019
• Study Completion: April 1, 2020
• Last Updated: March 18, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)