Thrombectomy in ST Elevation Myocardial Infarction, an Individual Patient Meta-analysis
1 other identifier
observational
18,000
0 countries
N/A
Brief Summary
During primary percutaneous coronary intervention, distal embolization of thrombus and impaired microvascular perfusion has been associated with an increased mortality. Thrombectomy devices during primary percutaneous coronary intervention may prevent distal embolization by reducing thrombus burden and thus improve microvascular perfusion and reduce mortality.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2015
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2015
CompletedFirst Submitted
Initial submission to the registry
September 10, 2015
CompletedFirst Posted
Study publicly available on registry
September 17, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2016
CompletedOctober 25, 2017
October 1, 2017
1.2 years
September 10, 2015
October 23, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Occurrence of Cardiovascular death
time to event analysis
up to 30 days
Secondary Outcomes (1)
Occurrence of Cardiovascular death
up to 180 days
Other Outcomes (1)
Occurrence of Stroke
up to 30 days
Study Arms (2)
Manual Aspiration Thrombectomy with PCI
Subjects from the randomized controlled trials to be included in this meta-analysis will have been randomly allocated to Manual Aspiration Thrombectomy followed by percutaneous coronary intervention (PCI).
PCI Alone
Subjects from the randomized controlled trials to be included in this meta-analysis will have been randomly allocated to percutaneous coronary intervention (PCI) alone without manual aspiration thrombectomy.
Interventions
Eligibility Criteria
Patients with ST elevation myocardial infarction undergoing emergency percutaneous coronary intervention
You may qualify if:
- Randomized controlled trials comparing manual thrombectomy vs. percutaneous coronary intervention alone in patients with ST elevation myocardial infarction published between January 1980 and April 2015.
- Large trials randomizing more than 1000 patients.
- Trials must have had at least 30 day follow up.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Population Health Research Institutelead
- Uppsala Universitycollaborator
- Region Örebro Countycollaborator
- University Medical Center Groningencollaborator
- University of Groningencollaborator
Related Publications (1)
Jolly SS, James S, Dzavik V, Cairns JA, Mahmoud KD, Zijlstra F, Yusuf S, Olivecrona GK, Renlund H, Gao P, Lagerqvist B, Alazzoni A, Kedev S, Stankovic G, Meeks B, Frobert O. Thrombus Aspiration in ST-Segment-Elevation Myocardial Infarction: An Individual Patient Meta-Analysis: Thrombectomy Trialists Collaboration. Circulation. 2017 Jan 10;135(2):143-152. doi: 10.1161/CIRCULATIONAHA.116.025371. Epub 2016 Dec 9.
PMID: 27941066DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Sanjit S Jolly, MD
Population Health Research Institute
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 10, 2015
First Posted
September 17, 2015
Study Start
September 1, 2015
Primary Completion
November 1, 2016
Study Completion
November 1, 2016
Last Updated
October 25, 2017
Record last verified: 2017-10