Functional Imaging of Social Cognition in Premanifest Huntington's Disease

NCT02551705 | Unknown

• 1 other identifier: S58457
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

Huntington's disease (HD) is a genetic progressive fatal neurodegenerative disorder. In the western world it affects 5-10 persons per 100000. The main brain changes include the loss of brain cells in subcortical structures. The symptoms of HD include involuntary movements, cognitive deterioration and behavioural disturbances. It has been shown that changes in emotion comprehension occur before the onset of the motor symptoms (preHD). This deficit in perception of emotions has been primarily investigated by means of facial expressions. However, emotions can also be expressed through body language. Here, the investigators propose to investigate whether the emotion comprehension deficit in preHD also includes body language comprehension.

Conditions

Huntington's Disease

Outcome Measures

Primary Outcomes (1)

• Significant group differences in brain activation for perceiving emotional vs neutral faces by following random effects analyses

  Significant group differences in beta-values for the contrast emotional faces vs neutral faces following general linear model parameter estimates

  6 months

Study Arms (2)

functional Imaging mutation carrier

EXPERIMENTAL

Premanifest mutation carrier, behavioral and neural emotional memory processing

Other: functional Imaging

functional Imaging non-carrier

ACTIVE COMPARATOR

non-carrier family member, behavioral and neural emotional memory processing

Other: functional Imaging

Interventions

functional Imaging OTHER

Brain responses associated with emotional memory will be investigated

functional Imaging mutation carrier; functional Imaging non-carrier

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Huntington's disease positive genotype and non-carrier siblings

You may not qualify if:

• visible chorea
• MRI contra-indications
• major neurological/psychiatric comorbidity

Sponsors & Collaborators

• Universitaire Ziekenhuizen KU Leuven: lead

MeSH Terms

Conditions

Huntington Disease

Interventions

Functional Neuroimaging

Condition Hierarchy (Ancestors)

Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Dementia; Chorea; Dyskinesias; Movement Disorders; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Neuroimaging; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Neurological; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Post-doctoral researcher

Study Record Dates

• First Submitted: September 7, 2015
• First Posted: September 16, 2015
• Study Start: October 1, 2015
• Primary Completion: October 1, 2017
• Study Completion: October 1, 2017
• Last Updated: September 16, 2015

Record last verified: 2015-09