NCT02542059|Unknown
Visualizing Beta Cells After Bariatric Surgery
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Visualizing Beta Cells in Patients With Remission of T2DM After Bariatric Surgery
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Visualizing Beta Cells in Patients With Remission of T2DM After Bariatric Surgery
Sponsor study identifier
observational
24
1 country
2
Study Start
August 2015
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
July 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
July 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
In order to evaluate the difference in beta cell mass in patients with and without complete resolution of type 2 diabetes mellitus (T2DM) after Roux en Y gastric bypass (RYGB) investigators aim to compare quantitative PET imaging of the pancreas between these patient groups. These highly relevant data will provide investigators with more information on the possible role of beta cell mass in the mechanisms behind resolution of T2DM after bariatric surgery. This would be of great interest for the assessment of RYGB as an alternative therapy in patients with T2DM with a BMI \<35, who currently do not meet the international guidelines for bariatric surgery.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 2015
Date type not reportedThis date has not been verified as actual or estimated.
August 18, 2015
Actual (reported)September 4, 2015
Actual (reported)July 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
July 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Beta cell mass measured by uptake of 68Ga-exendin in the pancreas on PET images
1 year
Comparing uptake of 68Ga-exendin in the pancreas with blood glucose and insulin measured after glucose ingestion and arginine infusion
1 year
Patients with resolved type 2 diabetes after bariatric surgery, will undergo 68Ga-exendin PET/CT
Patients with unresolved type 2 diabetes after bariatric surgery, will undergo 68Ga-exendin PET/CT
68Ga-exendin PET/CT
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Indiciduals who have undergone RYGB at least 1 year earlier at the Rijnstate Hospital in Arnhem.
Rijnstate Hospital
Arnhem, Gelderland, 6815 AD, Netherlands
RadboudUMC
Nijmegen, Gelderland, 6500HB, Netherlands
Tokgoz S, Deden LN, Hofboer A, Meijer RI, Hazebroek EJ, van Bon AC, de Galan BE, Tack CJ, Boss M, Gotthardt M. Beta cell function and mass in individuals with and without remission of type 2 diabetes after Roux-en-Y gastric bypass. Diabetologia. 2026 May;69(5):1295-1300. doi: 10.1007/s00125-025-06659-1. Epub 2026 Jan 20.
Martin Gotthardt, Prof. Dr.
Radboud University Medical Center
First Submitted
August 18, 2015
First Posted
September 4, 2015
Study Start
August 2015
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
July 2024
Estimated (date passed)Effects of Personalized Dietary Advice on Health Status of Diabetes Type 2 Patients
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This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
July 2024
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
December 8, 2023
Record last verified: 2023-11
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Source: ClinicalTrials.gov.
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