Consumption of Dairy Yogurt Enhanced Immune Function
Consumption of Dairy Yogurt With Rhamnogalacturonan in Korean Citrus Hallabong Peel Polysaccharide Enhanced Immune Function and Attenuated Inflammatory Response
1 other identifier
interventional
120
1 country
1
Brief Summary
To investigate the impact of consumption of dairy yogurt with rhamnogalacturonan (RG) in Korean citrus Hallabong peel polysaccharide on Natural Killer (NK) cell activity and circulating cytokine levels.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_2 healthy-volunteers
Started Jun 2014
Shorter than P25 for phase_2 healthy-volunteers
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2015
CompletedFirst Submitted
Initial submission to the registry
August 26, 2015
CompletedFirst Posted
Study publicly available on registry
August 28, 2015
CompletedApril 12, 2016
April 1, 2016
9 months
August 26, 2015
April 11, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
serum cytokine concentrations
Primary outcome will be tested before and after intervention
change from baseline in RG at 8 weeks
Study Arms (2)
test group
EXPERIMENTALDietary Supplement: RG consumed one pack (150ml) of dairy yogurt containing RG (100mg Korean citrus Hallabong peel polysaccharide) per day for 8 weeks
placebo
PLACEBO COMPARATORDietary Supplement: placebo consumed one pack (150ml) of dairy yogurt without RG per day for 8 weeks
Interventions
Eligibility Criteria
You may qualify if:
- The levels of white blood cells under 8x10\^3/μL
- males and females
- years old
- nondiabetic and nonobese subjects
- able to give informed consent
You may not qualify if:
- consumption of any probiotic products within 1 month before screening
- unstable body weight (body-weight change \> 2 kg within 3 months before screening)
- diabetes
- history/presence of significant metabolic disease
- pregnancy or breast-feeding
- acute or chronic infection
- liver disease, kidney disease, gastrointestinal disease, or any other acute or chronic disease requiring treatment
- subjects taking any drugs or supplements
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Yonsei University
Seoul, 120-749, South Korea
Related Publications (1)
Lee MH, Kim M, Kim M, Kwak JH, Chang DH, Yu WK, Lee SH, Lee JH. Consumption of dairy yogurt with the polysaccharide rhamnogalacturonan from the peel of the Korean citrus hallabong enhances immune function and attenuates the inflammatory response. Food Funct. 2016 Jun 15;7(6):2833-9. doi: 10.1039/c5fo01103e.
PMID: 27225729DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Jong-Ho Lee, PhD
Yonsei University
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 26, 2015
First Posted
August 28, 2015
Study Start
June 1, 2014
Primary Completion
March 1, 2015
Study Completion
March 1, 2015
Last Updated
April 12, 2016
Record last verified: 2016-04