Effect of Topically-Applied Hyaluronic-Acid on Palatal Epithelial Wound Closure
1 other identifier
interventional
36
0 countries
N/A
Brief Summary
Aim of the study is to assess the therapeutic effects of topical hyaluronic-acid use on secondary wound healing of the free gingival graft donor site. The hypothesis of this study is that topical hyaluronic-acid gel has positive effects on secondary wound healing of free gingival graft donor site by reducing pain, burning sensation, and accelerating the healing.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_4
Started Aug 2013
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2015
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2015
CompletedFirst Submitted
Initial submission to the registry
August 17, 2015
CompletedFirst Posted
Study publicly available on registry
August 27, 2015
CompletedAugust 27, 2015
August 1, 2015
1.9 years
August 17, 2015
August 25, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Pain
Using a visual analog scale (0: No pain, 10: Severe pain)
21 days
Secondary Outcomes (4)
Color match
42 days
Consistency
42 days
Epithelialisation
42 days
Burning Sensation
21 days
Study Arms (3)
Periodontal dressing material
ACTIVE COMPARATORPalatal wound area was covered with periodontal dressing material at baseline and 3rd day
0.2% Hyaluronic acid gel
EXPERIMENTAL0.2% topical hyaluronic-acid gel was applied to palatal wound area and covered with periodontal dressing material (Peripac®) at baseline and 3rd day
0.8% Hyaluronic acid gel
EXPERIMENTAL0.8% topical hyaluronic-acid gel was applied palatal wound area and covered with periodontal dressing material (Peripac®) at baseline and 3rd day
Interventions
Procedure:Palatal wound area was covered with periodontal dressing material at baseline and 3rd day
0.2% topical hyaluronic-acid gel was applied to palatal wound area and covered with periodontal dressing material (Peripac®) at baseline and 3rd day
0.8% topical hyaluronic-acid gel was applied palatal wound area and covered with periodontal dressing material (Peripac®) at baseline and 3rd day
Eligibility Criteria
You may qualify if:
- Good general health
- No periodontal surgical treatment in the previous 6 months on the involved sites
You may not qualify if:
- Smoking
- Patients with a pregnancy or lactation period
- Self-reported history of antibiotic medication within three months
- Absence of tooth in the area of donor site
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Interventions
Study Officials
- STUDY DIRECTOR
Bahar Kuru, Prof. Dr.
Marmara University, Faculty of Denistry, Department of Periodontology
- STUDY CHAIR
Başak Doğan, Prof. Dr.
Marmara University, Faculty of Denistry, Department of Periodontology
- PRINCIPAL INVESTIGATOR
Hatice Selin Yıldırım, Dr.
Marmara University, Faculty of Denistry, Department of Periodontology
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 17, 2015
First Posted
August 27, 2015
Study Start
August 1, 2013
Primary Completion
July 1, 2015
Study Completion
August 1, 2015
Last Updated
August 27, 2015
Record last verified: 2015-08