NCT02528253

Brief Summary

This study will investigate the efficacy and safety of tanezumab 5 mg and 10 mg administered by subcutaneous injection seven times at 8 week intervals (56 weeks). The primary objective of this study is to evaluate the effectiveness of tanezumab 10 mg and 5 mg compared to placebo for the treatment of chronic low back pain. Secondary objectives are to evaluate the long-term safety and effectiveness of tanezumab 10 mg and 5 mg compared to placebo for the treatment of chronic low back pain. In addition, the study will evaluate the effectiveness and long term safety profile of tanezumab treatment for chronic low back pain compared to tramadol Prolonged Release (PR), a medication commonly utilized for the treatment of chronic low back pain.

Trial Health

93
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,832

participants targeted

Target at P75+ for phase_3 low-back-pain

Timeline
Completed

Started Aug 2015

Longer than P75 for phase_3 low-back-pain

Geographic Reach
9 countries

262 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 11, 2015

Completed
7 days until next milestone

Study Start

First participant enrolled

August 18, 2015

Completed
1 day until next milestone

First Posted

Study publicly available on registry

August 19, 2015

Completed
2.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 17, 2017

Completed
1.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 20, 2018

Completed
1.2 years until next milestone

Results Posted

Study results publicly available

February 21, 2020

Completed
Last Updated

February 21, 2020

Status Verified

February 1, 2020

Enrollment Period

2.2 years

First QC Date

August 11, 2015

Results QC Date

December 19, 2019

Last Update Submit

February 6, 2020

Conditions

Keywords

Chronic low back painChronic pain

Outcome Measures

Primary Outcomes (1)

  • Change From Baseline in Average Low Back Pain Intensity (LBPI) Score for Tanezumab Versus (Vs) Placebo at Week 16

    Average low back pain was assessed on an 11-point numeric rating scale (NRS) captured through an interactive response technology (IRT). Participants described their average low back pain during the past 24 hours on a scale ranging from 0 (no pain) to 10 (worst possible pain), where higher scores indicated higher pain.

    Baseline, Week 16

Secondary Outcomes (65)

  • Change From Baseline in Roland Morris Disability Questionnaire (RMDQ) at Week 16 for Tanezumab Versus (Vs) Placebo

    Baseline, Week 16

  • Change From Baseline in Average Low Back Pain Intensity (LBPI) Score for Tanezumab Versus (Vs) Tramadol at Week 16

    Baseline, Week 16

  • Change From Baseline in Average Low Back Pain Intensity (LBPI) Score at Weeks 2, 4, 8, 12, 24, 32, 40, 48 and 56

    Baseline, Weeks 2, 4, 8, 12, 24, 32, 40, 48 and 56

  • Change From Baseline in Daily Average Low Back Pain Intensity (LBPI) Score at Week 64

    Baseline, Week 64

  • Change From Baseline in Roland Morris Disability Questionnaire (RMDQ) Total Score at Weeks 2, 4, 8, 16 (for Tanezumab vs Tramadol) 24, 32, 40, 48 and 56

    Baseline, Weeks 2, 4, 8, 16, 24, 32, 40, 48 and 56

  • +60 more secondary outcomes

Study Arms (5)

Placebo to Week 16; tanezumab 5 mg SC

PLACEBO COMPARATOR
Biological: Placebo to Week 16; tanezumab 5mg SC

Placebo to Week 16, tanezumab 10 mg SC

PLACEBO COMPARATOR
Biological: Placebo to Week 16, tanezumab 10 mg SC

Tanezumab 5 mg SC

EXPERIMENTAL
Biological: Tanezumab 5 mg SC

Tanezumab 10 mg SC

EXPERIMENTAL
Biological: Tanezumab 10 mg SC

Tramadol PR oral

ACTIVE COMPARATOR
Biological: Tramadol PR oral

Interventions

Placebo SC injection every 8 weeks for 2 injections followed by tanezumab 5 mg injection every 8 weeks for 5 injections

Placebo to Week 16; tanezumab 5 mg SC

Placebo SC injection every 8 weeks for 2 injections, followed by tanezumab 10 mg SC injection for 5 injections

Placebo to Week 16, tanezumab 10 mg SC

Tanezumab 5 mg SC

Tanezumab 5 mg SC

Tanezumab 10 mg SC

Tanezumab 10 mg SC

Tramadol PR oral

Tramadol PR oral

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Chronic low back pain ≥3 months in duration, Quebec Task Force in Spinal Disorders class 1 or 2, with documented history of previous inadequate treatment response to at least 3 different categories of agents commonly used and generally considered effective for the treatment of chronic low back pain.

You may not qualify if:

  • Diagnosis of osteoarthritis of the knee or hip as defined by the American College of Rheumatology (ACR) criteria.
  • Subjects who have Kellgren Lawrence Grade \> or =2 radiographic evidence of hip or Grade \> or=3 radiographic evidence of knee osteoarthritis will be excluded;
  • History or radiographic evidence of other diseases that could confound efficacy or safety assessments (e.g., rheumatoid arthritis).
  • History or radiographic evidence of orthopedic conditions that may increase the risk of, or confound assessment of joint safety conditions during the study.
  • Signs and symptoms of clinically significant cardiac disease within 6 months of the study (e.g., unstable angina, myocardial infarction, resting bradycardia, poorly controlled or untreated hypertension) as defined in the protocol or subjects with any other cardiovascular illness that in the opinion of the Investigator would render a subject unsuitable to participate in the study
  • History, diagnosis, or signs and symptoms of clinically significant neurological disease (e.g., transient ischemic attack, stroke, peripheral or autonomic neuropathy) as specified in the protocol
  • Subjects with evidence or symptoms consistent with autonomic dysfunction (e.g., orthostatic hypotension and/or autonomic symptoms) as defined in the protocol.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (262)

Central Alabama Research

Birmingham, Alabama, 35209, United States

Location

Cahaba Research

Birmingham, Alabama, 35242, United States

Location

Alabama Clinical Research, LLC

Mobile, Alabama, 36608, United States

Location

Alabama Orthopaedic Clinic, P.C.

Mobile, Alabama, 36608, United States

Location

Coastal Clinical Research

Mobile, Alabama, 36608, United States

Location

Horizon Research Partners, LLC

Mobile, Alabama, 36608, United States

Location

The Center for Clinical Trials, Inc.

Saraland, Alabama, 36571, United States

Location

Ferguson Family Medicine

Mesa, Arizona, 85215, United States

Location

The Pain Center of Arizona

Phoenix, Arizona, 85018, United States

Location

Arizona Research Center

Phoenix, Arizona, 85053, United States

Location

Valley Pain Consultants

Scottsdale, Arizona, 85254, United States

Location

KLR Business Group dba Arkansas Clinical Research

Little Rock, Arkansas, 72205, United States

Location

Lynn Institute of the Ozarks

Little Rock, Arkansas, 72205, United States

Location

Primary Care of Arkansas, P.A.

Little Rock, Arkansas, 72205, United States

Location

Anaheim Clinical Trials, LLC

Anaheim, California, 92801, United States

Location

Core Healthcare Group

Cerritos, California, 90703, United States

Location

eStudySite

Chula Vista, California, 91911, United States

Location

Triwest Research Associates, LLC

El Cajon, California, 92020, United States

Location

Research Center of Fresno, Inc.

Fresno, California, 93702, United States

Location

Neuro-Pain Medical Center

Fresno, California, 93710, United States

Location

Valley Research-Trials

Fresno, California, 93720, United States

Location

Collaborative Neuroscience Network, LLC.

Garden Grove, California, 92845, United States

Location

eStudySite

La Mesa, California, 91942, United States

Location

Collaborative Neuroscience Network, LLC.

Long Beach, California, 90806, United States

Location

University of Southern California

Los Angeles, California, 90033, United States

Location

USC IDS Pharmacy

Los Angeles, California, 90033, United States

Location

Catalina Research Institute, LLC

Montclair, California, 91763, United States

Location

Providence Clinical Research

North Hollywood, California, 91606, United States

Location

Northern California Research

Sacramento, California, 95821, United States

Location

Artemis Institute for Clinical Research

San Diego, California, 92103, United States

Location

Encompass Clinical Research

Spring Valley, California, 91978, United States

Location

Bayview Research Group

Valley Village, California, 91607, United States

Location

Diablo Clinical Research, Inc.

Walnut Creek, California, 94598, United States

Location

Elite Clinical Trials, Inc.

Wildomar, California, 92595, United States

Location

Alpine Clinical Research Center

Boulder, Colorado, 80301, United States

Location

Mountain View Clinical Research, Inc.

Denver, Colorado, 80209, United States

Location

Mountain View Clinical Research, Inc

Denver, Colorado, 80209, United States

Location

New England Research Associates, LLC

Bridgeport, Connecticut, 06606, United States

Location

My Health 1st Urgent Care

Milford, Connecticut, 06460, United States

Location

Stamford Therapeutics Consortium

Stamford, Connecticut, 06905, United States

Location

JEM Research Institute

Atlantis, Florida, 33462, United States

Location

Orthopedic Research Institute

Boynton Beach, Florida, 33472, United States

Location

Clinical Research of South Florida

Coral Gables, Florida, 33134, United States

Location

Avail Clinical Research,LLC

DeLand, Florida, 32720, United States

Location

Midland Florida Clinical Research Center, LLC

DeLand, Florida, 32720, United States

Location

S&W Clinical Research

Fort Lauderdale, Florida, 33306, United States

Location

MD Clinical

Hallandale, Florida, 33009, United States

Location

Pines Clinical Research Inc.

Hollywood, Florida, 33024, United States

Location

Clinical Neuroscience Solutions, Inc.

Jacksonville, Florida, 32256, United States

Location

Health Awareness, Inc.

Jupiter, Florida, 33458, United States

Location

Columbus Clinical Services, LLC

Miami, Florida, 33125, United States

Location

Larkin Imaging Center

Miami, Florida, 33173, United States

Location

M & M Medical Center, Inc

Miami, Florida, 33185, United States

Location

Quality Research & Medical Center LLC

Miami, Florida, 33186, United States

Location

Crystal Biomedical Research, LLC

Miami Lakes, Florida, 33014, United States

Location

Sensible Healthcare, LLC.

Ocoee, Florida, 34761, United States

Location

Compass Research, LLC

Orlando, Florida, 32806, United States

Location

National Pain Research Institute

Orlando, Florida, 32807, United States

Location

Progressive Medical Research

Port Orange, Florida, 32127, United States

Location

Gulfcoast Research Institute

Sarasota, Florida, 34232, United States

Location

Meridien Research

St. Petersburg, Florida, 33709, United States

Location

Meridien Research

Tampa, Florida, 33634, United States

Location

Palm Beach Research Center

West Palm Beach, Florida, 33409, United States

Location

River Birch Research Alliance, LLC

Blue Ridge, Georgia, 30513, United States

Location

Columbus Regional Research Institute

Columbus, Georgia, 31904, United States

Location

Center for Advanced Research & Education

Gainesville, Georgia, 30501, United States

Location

Drug Studies America

Marietta, Georgia, 30060, United States

Location

Georgia Institute for Clinical Research, LLC

Marietta, Georgia, 30060, United States

Location

Non-Surgical Orthopaedics, P.C.

Marietta, Georgia, 30060, United States

Location

Better Health Clinical Research Inc

Newnan, Georgia, 30265, United States

Location

Better Health Clinical Research, Inc.

Newnan, Georgia, 30265, United States

Location

Southeast Regional Research Group

Savannah, Georgia, 31401, United States

Location

North Georgia Clinical Research

Woodstock, Georgia, 30189, United States

Location

North Georgia Internal Medicine

Woodstock, Georgia, 30189, United States

Location

East-West Medical Research Institute

Honolulu, Hawaii, 96814, United States

Location

Medex Healthcare Research Inc

Chicago, Illinois, 60602, United States

Location

Chicago Clinical Research Institute, Inc.

Chicago, Illinois, 60607, United States

Location

Northwestern Memorial Hospital - Arkes Pavilion, Diagnostic Testing Center

Chicago, Illinois, 60611, United States

Location

Northwestern University Feinberg School of Medicine

Chicago, Illinois, 60611, United States

Location

Northwestern University, Feinberg School of Medicine, Lavin Pavilion

Chicago, Illinois, 60611, United States

Location

Northwestern University

Chicago, Illinois, 60611, United States

Location

Great Lakes Clinical Trials

Chicago, Illinois, 60640, United States

Location

Chicago Anesthesia Pain Specialists

Chicago, Illinois, 60657, United States

Location

Clinical Investigation Specialists, Inc.

Skokie, Illinois, 60076, United States

Location

Investigators Research Group, LLC

Brownsburg, Indiana, 46112, United States

Location

MediSphere Medical Research Center, LLC

Evansville, Indiana, 47714, United States

Location

Lafayette Clinical Research Group

Lafayette, Indiana, 47905, United States

Location

Lafayette Regional Vein and Laser Center

Lafayette, Indiana, 47905, United States

Location

Buynak Clinical Research, P.C.

Valparaiso, Indiana, 46383, United States

Location

The Iowa Clinic - Internal Medicine

Des Moines, Iowa, 50309, United States

Location

The Iowa Clinic Medical Imaging

Des Moines, Iowa, 50309, United States

Location

The Iowa Clinic

Des Moines, Iowa, 50309, United States

Location

The Iowa Clinic Medical Imaging

West Des Moines, Iowa, 50266, United States

Location

The Iowa Clinic

West Des Moines, Iowa, 50266, United States

Location

Mid-America Physiatrists, P.A.

Overland Park, Kansas, 66210, United States

Location

Professional Research Network of Kansas, LLC

Wichita, Kansas, 67205, United States

Location

Mayfield Imaging Center

Crestview Hills, Kentucky, 41017, United States

Location

Otri-Med Corporation

Edgewood, Kentucky, 41017, United States

Location

St Elizabeth Hospital Edgewood

Edgewood, Kentucky, 41017, United States

Location

Willis-Knighton Physician Network/ Spine and Pain Specialist

Bossier City, Louisiana, 71111, United States

Location

Willis-Knighton Physician Network/WKB Family Medicine Associates

Bossier City, Louisiana, 71111, United States

Location

Centex Studies, Inc

Lake Charles, Louisiana, 70601, United States

Location

Best Clinical Trials, LLC

New Orleans, Louisiana, 70115, United States

Location

George Stanley Walker, MD

New Orleans, Louisiana, 70115, United States

Location

Klein & Associates, M.D., P.A.

Cumberland, Maryland, 21502, United States

Location

The Center for Rheumatology and Bone Research

Wheaton, Maryland, 20902, United States

Location

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

Location

Brigham and Women's Hospital

Chestnut Hill, Massachusetts, 02467, United States

Location

Beacon Clinical Research, LLC

Quincy, Massachusetts, 02169, United States

Location

MedVadis Research Corporation

Watertown, Massachusetts, 02472, United States

Location

Great Lakes Research Group, Inc.

Bay City, Michigan, 48706, United States

Location

Michigan Orthopaedic Spine Surgeons

Rochester Hills, Michigan, 48307, United States

Location

Oakland Medical Research

Troy, Michigan, 48085, United States

Location

Michigan Pain Consultants

Wyoming, Michigan, 49519, United States

Location

CRC of Jackson, LLC

Jackson, Mississippi, 39202, United States

Location

Physician's Surgery Center

Jackson, Mississippi, 39202, United States

Location

Olive Branch Family Medical Center

Olive Branch, Mississippi, 38654, United States

Location

Medex Healthcare Research, Inc.

St Louis, Missouri, 63117, United States

Location

Heartland Clinical Research, Inc.

Omaha, Nebraska, 68134, United States

Location

Affiliated Clinical Research, Inc.

Las Vegas, Nevada, 89106, United States

Location

Office of Stephen H. Miller, MD

Las Vegas, Nevada, 89117, United States

Location

Office of Robert Kaplan, DO

Las Vegas, Nevada, 89119, United States

Location

Advanced Biomedical Research of America

Las Vegas, Nevada, 89123, United States

Location

ActivMed Practices & Research, Inc.

Portsmouth, New Hampshire, 03801, United States

Location

Comprehensive Clinical Research

Berlin, New Jersey, 08009, United States

Location

CRI Worldwide, LLC

Marlton, New Jersey, 08053, United States

Location

University Clinical Research Center

Somerset, New Jersey, 08873, United States

Location

Premier Research

Trenton, New Jersey, 08611, United States

Location

Albuquerque Clinical Trials, Inc.

Albuquerque, New Mexico, 87102, United States

Location

New Mexico Clinical Research & Osteoporosis Center, Inc.

Albuquerque, New Mexico, 87106, United States

Location

Healthwise Medical Associates

Brooklyn, New York, 11206, United States

Location

Drug Trials America

Hartsdale, New York, 10530, United States

Location

The Medical Research Network, LLC

New York, New York, 10128, United States

Location

AAIR Research Center

Rochester, New York, 14618, United States

Location

University of Rochester

Rochester, New York, 14618, United States

Location

Northstate Clinical Research

Lenoir, North Carolina, 28645, United States

Location

On Site Clinical Solutions, LLC

Mooresville, North Carolina, 28117, United States

Location

Wake Research Associates, LLC

Raleigh, North Carolina, 27612, United States

Location

PMG Research of Winston-Salem, LLC

Winston-Salem, North Carolina, 27103, United States

Location

The Center for Clinical Research

Winston-Salem, North Carolina, 27103, United States

Location

Lillestol Research, LLC

Fargo, North Dakota, 58104, United States

Location

Plains Clinical Research Center, LLC

Fargo, North Dakota, 58104, United States

Location

Heartland Diagnostics

Frgi, North Dakota, 58104, United States

Location

Clinical Inquest Center Ltd

Beavercreek, Ohio, 45431, United States

Location

Valley Medical Research/Valley Medical Primary Care

Centerville, Ohio, 45459, United States

Location

Hightop Medical Research Center

Cincinnati, Ohio, 45224, United States

Location

New Horizons Clinical Research

Cincinnati, Ohio, 45242, United States

Location

Optimed Research LTD

Columbus, Ohio, 43235, United States

Location

Prestige Clinical Research

Franklin, Ohio, 45005, United States

Location

Great Lakes Medical Research, LLC

Mentor, Ohio, 44060, United States

Location

Oaktree Clinic

Mentor, Ohio, 44060, United States

Location

Bone Joint & Spine Surgeons, Inc.

Toledo, Ohio, 43623, United States

Location

COR Clinical Research, L.L.C

Oklahoma City, Oklahoma, 73103, United States

Location

Health Research of Oklahoma

Oklahoma City, Oklahoma, 73103, United States

Location

NPC Research

Oklahoma City, Oklahoma, 73109, United States

Location

Lynn Health Science Institute

Oklahoma City, Oklahoma, 73112, United States

Location

Brandywine Clinical Research

Downingtown, Pennsylvania, 19335, United States

Location

Altoona Center for Clinical Research

Duncansville, Pennsylvania, 16635, United States

Location

Omega Medical Research

Warwick, Rhode Island, 02886, United States

Location

TLM Medical Services

Columbia, South Carolina, 29204, United States

Location

DeGarmo Institute of Medical Research

Greer, South Carolina, 29650, United States

Location

Lowcountry Orthopaedics & Sports Medicine

North Charleston, South Carolina, 29406, United States

Location

Health Concepts

Rapid City, South Dakota, 57702, United States

Location

PCET Research Center, LLC

Knoxville, Tennessee, 37909, United States

Location

Quality Medical Research

Nashville, Tennessee, 37211, United States

Location

KRK Medical Research

Arlington, Texas, 76012, United States

Location

Advances In Health

Houston, Texas, 77030, United States

Location

Centex Studies, Inc./Clear Lake Family Physicians

Houston, Texas, 77058, United States

Location

Clinical Trial Network

Houston, Texas, 77074, United States

Location

The Pain Relief Center

Plano, Texas, 75024, United States

Location

Quality Research, Inc.

San Antonio, Texas, 78209, United States

Location

Lee Medical Associates, PA

San Antonio, Texas, 78213, United States

Location

Progressive Clinical Research, PA

San Antonio, Texas, 78213, United States

Location

Physicians Research Options, LLC

Draper, Utah, 84020, United States

Location

Charlottesville Medical Research Center, LLC

Charlottesville, Virginia, 22911, United States

Location

Virginia Research Center

Midlothian, Virginia, 23114, United States

Location

National Clinical Research - Richmond, Inc.

Richmond, Virginia, 23294, United States

Location

Washington Center for Pain Management

Bellevue, Washington, 98004, United States

Location

Northwest Clinical Research Center

Bellevue, Washington, 98007, United States

Location

SKDS Research Inc.

Newmarket, Ontario, L3Y 5G8, Canada

Location

London Road Diagnostic Clinic & Medical Centre

Sarnia, Ontario, N7T 4X3, Canada

Location

G.R.M.O. (Groupe de recherche en maladies osseuses) Inc.

Québec, Quebec, G1V 3M7, Canada

Location

Centre de recherche Saint-Louis

Québec, Quebec, G1W 4R4, Canada

Location

Diex Research Sherbrooke Inc.

Sherbrooke, Quebec, J1L 0H8, Canada

Location

A2 reumatologi og idraesmedicin ApS

Hillerød, 3400, Denmark

Location

Hopital Cochin

Paris, 75679, France

Location

Bekes Megyei Koezponti Korhaz Dr Rethy Pal Tagkorhaz

Békéscsaba, 5600, Hungary

Location

Clinexpert Egeszsegugyi Szolgaltato es Kereskedelmi Kft.

Budapest, 1033, Hungary

Location

Obudai Egeszsegugyi Centrum Ktf.

Budapest, 1036, Hungary

Location

Jutrix Kft.

Kecskemét, 6000, Hungary

Location

CRU Hungary Ltd., MISEK HOSPITAL

Miskolc, 3529, Hungary

Location

CRU Hungary Ltd., MISEK-Radiology Department

Miskolc, 3529, Hungary

Location

Clinfan Kft.

Szekszárd, 7100, Hungary

Location

Tolna Megyei Balassa Janos Korhaz, Ortopediai osztaly

Szekszárd, 7100, Hungary

Location

Aichi Medical University Hospital

Nagakute, Aichi-ken, 480-1195, Japan

Location

Nagoya University Hospital

Showa-ku, Nagoya, Aichi-ken, 466-8560, Japan

Location

Chiba University Hospital

Chuo-ku, Chiba, Chiba, 260-8677, Japan

Location

Funabashi Municipal Medical Center

Funabashi, Chiba, 273-8588, Japan

Location

Chiba Rosai Hospital

Ichihara, Chiba, 290-0003, Japan

Location

Chiba Central Medical Center

Wakaba-ku, Chiba, Chiba, 264-0017, Japan

Location

Fukuoka Mirai Hospital

Higashi-ku,Fukuoka, Fukuoka, 813-0017, Japan

Location

Kyushu Rosai Hospital

Kokuraminami-ku,Kitakyushu, Fukuoka, 800-0296, Japan

Location

Takagi Hospital

Ōkawa, Fukuoka, 831-0016, Japan

Location

Fukushima Medical University Aizu Medical Center

Aizu-Wakamatsu, Fukushima, 969-3492, Japan

Location

Hakodate Central General Hospital

Hakodate, Hokkaido, 040-8585, Japan

Location

Hakodate Ohmura Orthopedic Hospital

Hakodate, Hokkaido, 041-0802, Japan

Location

Kobe Konan Yamate Clinic

Higashinada-ku, Kobe, Hyōgo, 658-0011, Japan

Location

Omuro Orthopedic Clinic

Himeji, Hyōgo, 670-0976, Japan

Location

Medical corporate corporation hoshikai Onishi medical clinic

Kako-gun, Hyōgo, 675-1115, Japan

Location

Kobe Red Cross Hospital

Kobe, Hyōgo, 651-0073, Japan

Location

National Hospital Organization Kanazawa Medical Center

Kanazawa, Ishikawa-ken, 920-8650, Japan

Location

Morita Hospital

Komatsu, Ishikawa-ken, 923-8507, Japan

Location

Marunouchi Hospital

Matsumoto, Nagano, 390-8601, Japan

Location

National Hospital Organization Beppu Medical Center

Beppu, Oita Prefecture, 874-0011, Japan

Location

Sobajima Clinic

Higashiosaka, Osaka, 577-0011, Japan

Location

Rinku General Medical Center

Izumisano, Osaka, 598-8577, Japan

Location

Minamiosaka Hospital

Suminoe-ku, Osaka, Osaka, 559-0012, Japan

Location

Saitama Jikei Hospital

Kumagaya, Saitama, 360-0816, Japan

Location

Hamamatsu University School of Medicine, University Hospital

Hamamatsu, Shizuoka, 431-3192, Japan

Location

Tokyo Medical and Dental University Medical Hospital

Bunkyo-ku, Tokyo, 113-8519, Japan

Location

Fussa Hospital

Fussa, Tokyo, 197-8511, Japan

Location

Tokyo Saiseikai Central Hospital

Minato-ku, Tokyo, 108-0073, Japan

Location

Kohno Clinical Medicine Research Institute Daisan Kitashinagawa Hospital

Shinagawa-ku, Tokyo, 140-0001, Japan

Location

Ohimachi Orthopaedic Clinic

Shinagawa-ku, Tokyo, 140-0014, Japan

Location

Keio University Hospital

Shinjuku-ku, Tokyo, 160-8582, Japan

Location

Yonezawa City Hospital

Yonezawa, Yamagata, 992-8502, Japan

Location

Shimonoseki City Hospital

Shimonoseki-shi, Yamaguchi, 750-8520, Japan

Location

Yamaguchi University Hospital

Ube, Yamaguchi, 755-8505, Japan

Location

Chihaya Hospital

Fukuoka, 813-8501, Japan

Location

Kuroda Orthopedic Hospital

Fukuoka, 814-0165, Japan

Location

Fukushima Medical University Hospital

Fukushima, 960-1295, Japan

Location

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital

Hiroshima, 730-8619, Japan

Location

Saitama Municipal Hospital

Saitama, 336-8522, Japan

Location

Toyama University Hospital

Toyama, 930-0194, Japan

Location

CTC Pharmacy, Seoul National University Hospital

Seoul, 03080, South Korea

Location

Seoul National University Hospital

Seoul, 03080, South Korea

Location

CTC Pharmacy, Severance Hospital

Seoul, 03722, South Korea

Location

Severance Hospital

Seoul, 03722, South Korea

Location

Clinical Trial Pharmacy, Samsung Medical Center

Seoul, 06351, South Korea

Location

Samsung Medical Center

Seoul, 06351, South Korea

Location

Hospital Nuestra Senora de la Esperanza

Santiago de Compostela, A Coruna, 15705, Spain

Location

Complejo Hospitalario Universitario A Coruna. Servicio de Farmacia

A Coruña, 15006, Spain

Location

Complejo Hospitalario Universitario A Coruña

A Coruña, 15006, Spain

Location

Instituto de Ciencias Medicas

Alicante, 03004, Spain

Location

Hospital de Mar Servicio de Radiologia

Barcelona, 08003, Spain

Location

Hospital del Mar Servicio de Farmacia

Barcelona, 08003, Spain

Location

Specialist, S.L.

Barcelona, 08006, Spain

Location

Specialist. Farmacia

Barcelona, 08006, Spain

Location

Hospital del Mar

Barcelona, 08024, Spain

Location

Hospital Universitario Quiron-Dexeus

Barcelona, 08025, Spain

Location

Hospital Universitario Quiron-Dexeus. Servicio de Farmacia

Barcelona, 08028, Spain

Location

Hospital Sanitas CIMA

Barcelona, 08034, Spain

Location

Hospital Universitario La Paz.

Madrid, 28046, Spain

Location

Hospital Universitario La Paz

Madrid, 28046, Spain

Location

Hospital La Moraleja. Pharmacy Service

Madrid, 28050, Spain

Location

Hospital La Moraleja

Madrid, 28050, Spain

Location

Hospital Regional Universitario de Malaga

Málaga, 29009, Spain

Location

Hospital Regional Universitario del Malaga

Málaga, 29009, Spain

Location

CTC (Clinical Trial Center) Sahlgrenska University Hospital

Gothenburg, 413 45, Sweden

Location

Pharmasite

Helsingborg, 252 20, Sweden

Location

Pharmasite

Malmo, 21152, Sweden

Location

ProbarE i Stockholm AB

Stockholm, 111 37, Sweden

Location

Related Publications (2)

  • Markman JD, Schnitzer TJ, Perrot S, Beydoun SR, Ohtori S, Viktrup L, Yang R, Bramson C, West CR, Verburg KM. Clinical Meaningfulness of Response to Tanezumab in Patients with Chronic Low Back Pain: Analysis From a 56-Week, Randomized, Placebo- and Tramadol-Controlled, Phase 3 Trial. Pain Ther. 2022 Dec;11(4):1267-1285. doi: 10.1007/s40122-022-00424-7. Epub 2022 Aug 13.

  • Markman JD, Bolash RB, McAlindon TE, Kivitz AJ, Pombo-Suarez M, Ohtori S, Roemer FW, Li DJ, Viktrup L, Bramson C, West CR, Verburg KM. Tanezumab for chronic low back pain: a randomized, double-blind, placebo- and active-controlled, phase 3 study of efficacy and safety. Pain. 2020 Sep 1;161(9):2068-2078. doi: 10.1097/j.pain.0000000000001928.

Related Links

MeSH Terms

Conditions

Low Back PainChronic Pain

Interventions

tanezumab

Condition Hierarchy (Ancestors)

Back PainPainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Results Point of Contact

Title
Pfizer ClinicalTrials.gov Call Center
Organization
Pfizer, Inc.

Study Officials

  • Pfizer CT.gov Call Center

    Pfizer

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 11, 2015

First Posted

August 19, 2015

Study Start

August 18, 2015

Primary Completion

October 17, 2017

Study Completion

December 20, 2018

Last Updated

February 21, 2020

Results First Posted

February 21, 2020

Record last verified: 2020-02

Data Sharing

IPD Sharing
Will share

Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical\_trials/trial\_data\_and\_results/data\_requests.

More information

Locations