Seoul National University Airway Registry

NCT02527486 | Recruiting DMC

• 1 other identifier: AW_registry
• Study Type: observational
• Target: 800
• Locations: 1 country
• Sites: 3

Brief Summary

This is a multicenter, prospective observational cohort study, in which patients with chronic airway diseases including chronic obstructive pulmonary disease(COPD), asthma, asthma-COPD overlap syndrome (ACOS) will be recruited.

Conditions

Chronic Obstructive Pulmonary Disease (COPD); Asthma; Asthma With Chronic Obstructive Pulmonary Disease; Bronchiectasis; Inactive Tuberculosis of Lung; Chronic Obstructive Airway Disease

Keywords

COPD; Asthma; ACOS; Bronchiectasis

Outcome Measures

Primary Outcomes (1)

• Death (time to death)

  death from any cause, death from COPD-specific cause, death from CVD, malignancy

  upto 20 years

Secondary Outcomes (1)

• post-bronchodilator FEV1 change rates

  upto 20 years (at least 3 years)

Other Outcomes (2)

• Time to 1st exacerbation (definition of exacerbation is described below)

  upto 20 years

• Annual rate of exacerbation (definition of exacerbation is described below)

  upto 20 years

Study Arms (1)

No predefined subgroups

Eligibility Criteria

• Age: 20 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

COPD Asthma ACOS Bronchiectasis TB-destroyed lung Other chronic airway diseases

You may qualify if:

• Postbronchodilator FEV1/FVC \< 0.7 AND chronic respiratory symptom

You may not qualify if:

• Asthma
• Never smoker or \<5PY of smoking history AND Recurrent episodes of asthma symptoms (wheezing, dyspnea, chest tightness, cough) AND (either Positive BDR OR positive metacholine/mannitol/exercise provocation test)
• ACOS
• COPD AND Asthma (regardless of smoking status)

Sponsors & Collaborators

• Seoul National University Hospital: lead

Study Sites (3)

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 463-707, South Korea

RECRUITING

Seoul National University Hospital

Seoul, 110-744, South Korea

RECRUITING

Seoul Metropolitan Government-Seoul National University Boramae Medical Center

Seoul, 156-707, South Korea

ACTIVE NOT RECRUITING

Related Publications (2)

• Jo YS, Park S, Kim DK, Yoo CG, Lee CH. The cutoff point of clinical chronic obstructive pulmonary disease questionnaire for more symptomatic patients. BMC Pulm Med. 2018 Feb 27;18(1):38. doi: 10.1186/s12890-018-0601-0.

  PMID: 29482616 DERIVED

• Jo YS, Lee J, Yoon HI, Kim DK, Yoo CG, Lee CH. Different prevalence and clinical characteristics of asthma-chronic obstructive pulmonary disease overlap syndrome according to accepted criteria. Ann Allergy Asthma Immunol. 2017 Jun;118(6):696-703.e1. doi: 10.1016/j.anai.2017.04.010.

  PMID: 28583262 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Blood (whole blood, serum, plasma, buffy coat) Urine

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Asthma; Bronchiectasis

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Bronchial Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Chul-Gyu Yoo, M.D.

  Seoul National University Hospital

  STUDY CHAIR

Central Study Contacts

Chang-Hoon Lee, M.D.

CONTACT

82-2-2072-4743; kauri670@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Study Record Dates

• First Submitted: December 19, 2014
• First Posted: August 19, 2015
• Study Start: September 1, 2011
• Primary Completion: December 1, 2021
• Study Completion (Estimated): December 1, 2031
• Last Updated: August 19, 2015

Record last verified: 2015-08

Locations

KR (3)