Pupillary Response After Glaucoma Medication
pupil
Effect of Topical Anti-glaucoma Medications on Late Pupillary Light Reflex, as Evaluated by Pupillometry
1 other identifier
interventional
21
1 country
1
Brief Summary
Investigation of the effect on the pupillary constriction by latanoprost, dorzolamide,timolol in healthy subjects. The pupillary constriction is compared to no drug.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started May 2014
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2014
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2014
CompletedFirst Submitted
Initial submission to the registry
November 14, 2014
CompletedFirst Posted
Study publicly available on registry
August 13, 2015
CompletedAugust 13, 2015
August 1, 2015
6 months
November 14, 2014
August 11, 2015
Conditions
Outcome Measures
Primary Outcomes (1)
pupillary constriction measured as the post-illimination pupillay response (PIPR)
The pupillary diameter 0 to 10 seconds after light stimulation, the diameter is measured relative to the initial dark adapted pupil diameter
1 day
Study Arms (4)
Latanoprost
EXPERIMENTALsolution, 1 drop of 50ug/ml latanoprost, was given to study eye after washout period of 1 week between drugs
Timolol
EXPERIMENTALsolution, 1 drop of 5mg/ml timolol , was given to study eye after washout period of 1 week between drugs
dorzolamide
EXPERIMENTALsolution, 1 drop of 20 mg/ml dorzolamide, was given to study eye after washout period of 1 week between drugs
Other
NO INTERVENTIONno drug given and pupil measurements were performed before and at 30 and 180 min at equivalent hours as drugs measurements
Interventions
1 drop of latanoprost was given to study eye after washout period of 1 week between drugs
1 drop of timolol was given to study eye after washout period of 1 week between drugs
1 drop of dorzolamide was given to study eye after washout period of 1 week between drugs
Eligibility Criteria
You may qualify if:
- healthy subjects
You may not qualify if:
- ophthalmological diseases
- systemic disease
- smoking
- refractive error \>= 6 diopters
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Glostrup University Hospital
Glostrup Municipality, DK-2600, Denmark
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Henrik Lund-Andersen, Professor
Head of the project
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- md
Study Record Dates
First Submitted
November 14, 2014
First Posted
August 13, 2015
Study Start
May 1, 2014
Primary Completion
November 1, 2014
Study Completion
November 1, 2014
Last Updated
August 13, 2015
Record last verified: 2015-08