The Relationship of Adiponectin in Adipose Tissue, Thy-1 in Plaques, and Inflammatory Mediators With Cardiac Diseases

NCT02519257 | Completed

• 1 other identifier: FEMH-96091
• Study Type: interventional
• Target: 96
• Locations: 1 country
• Sites: 1

Brief Summary

Atherosclerosis is an inflammatory process in which immune mechanisms interact with metabolic risk factors to initiate, propagate, and activate lesions in the arterial trees and is known as the main cause of coronary artery disease (CAD). Recently, there are more and more studies highlighted the potential importance of adipose tissue in relation to inflammation effects on CAD pathogenesis. However, it remains unclear whether Thy-1, adiponectin or any other inflammatory mediators in mediastinal adipose tissue contribute to CAD. In this study, we aim to analyze the expression of inflammatory mediators' expression via in vitro assay (3T3-L1 cell culture) and in vivo assay (human adipose tissues).

Conditions

Heart Surgery

Keywords

CAD; VHD; Thy-1

Outcome Measures

Primary Outcomes (1)

• CD91 (Thy-1)

  up to 24 months

Secondary Outcomes (1)

• CD45

  up to 24 months

Study Arms (2)

CAD

EXPERIMENTAL

Patients with valve diseases proposed to have cardiac operations will be enrolled in this study, but those with congestive heart failure are excluded. Besides, those patients with valve diseases should have patent coronary arteries on coronary angiography.

Procedure: CAD

VHD

EXPERIMENTAL

Patients with valve diseases proposed to have cardiac operations will be enrolled in this study, but those with congestive heart failure are excluded. Besides, those patients with valve diseases should have patent coronary arteries on coronary angiography.

Procedure: VHD

Interventions

CAD PROCEDURE

Patients with CAD diseases proposed to have cardiac operations will be enrolled in this study, but those with congestive heart failure are excluded. Besides, those patients with valve diseases should have patent coronary arteries on coronary angiography.

Also known as: coronary artery disease

CAD

VHD PROCEDURE

Patients with valve diseases proposed to have cardiac operations will be enrolled in this study, but those with congestive heart failure are excluded. Besides, those patients with valve diseases should have patent coronary arteries on coronary angiography.

Also known as: valve diseases

VHD

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• coronary artery bypass grafting surgery
• valvular surgery

You may not qualify if:

• liver disease (GPT 2 times greater than normal limits)
• chronic renal insufficiency (Creatinine \> 2.0 mg/dL)
• neoplastic diseases
• taking steroids
• congestive heart failure

Sponsors & Collaborators

• Far Eastern Memorial Hospital: lead

Study Sites (1)

Far Eastern Memorial Hospital

New Taipei City, 220, Taiwan

Location

Related Publications (25)

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MeSH Terms

Interventions

JCAD protein, mouse

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: President

Study Record Dates

• First Submitted: August 2, 2015
• First Posted: August 10, 2015
• Study Start: August 1, 2008
• Primary Completion: July 1, 2010
• Study Completion: July 1, 2010
• Last Updated: August 10, 2015

Record last verified: 2015-08

Locations

TW (1)