The Expression of the Ionotropic Glutamate Receptors in Colon of IBS

NCT02512146 | Unknown DMC

• 1 other identifier: 2015SDU-QILU-G03
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The study aims to determine the expression of the ionotropic glutamate receptors in colon of irritable bowel syndrome (IBS) patients and evaluate the relationship between the ionotropic glutamate receptors and IBS symptoms.

Conditions

Irritable Bowel Syndrome

Keywords

IBS; Ionotropic glutamate receptors

Outcome Measures

Primary Outcomes (2)

• the expression of the ionotropic glutamate receptors

  Participants will examine the expression level of ionotropic glutamate receptors using quantitative real-time RT-PCR and western blot ,examine the distribution using immunohistochemy.

  4 months

• the relationship between the ionotropic glutamate receptors and IBS symptom

  Symptoms will be assessed though the severity of abdominal pain or discomfort and seizure frequency.Participants will evaluate the relationship between the expression level or the distribution of ionotropic glutamate receptors and IBS symptom. If there is a link between them, participants will study the underlying molecular mechanisms.

  6 months

Study Arms (2)

Irritable bowel syndrome

Patients meeting Rome III criteria of irritable bowel syndrome. Intervention: colonoscopy.

Procedure: colonoscopy

Normal controls

Asymptomatic individuals for health surveillance or patients for follow up after polypectomy. Intervention: colonoscopy.

Procedure: colonoscopy

Interventions

colonoscopy PROCEDURE

Patients will undergo colonoscopy and participants will get biopsies from the colon.

Irritable bowel syndrome; Normal controls

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients underwent colonoscopy in Qilu Hospital outpatient and inpatient department.

You may qualify if:

• Patients meeting IBS Rome III criteria. Asymptomatic individuals for health surveillance or patients for follow up after polypectomy.

You may not qualify if:

• Patients with known cancers or abdominal surgery. Alarm symptoms such as anaemia, gastrointestinal bleeding or obstruction, marked weight loss, abdominal mass. Patients who are unwilling to sign or give the informed consent form. Patients with impaired cardiac, liver or renal function. Patients with coagulopathy. Patients with pregnancy or breastfeeding.

Sponsors & Collaborators

• Shandong University: lead

Study Sites (1)

Department of Gastroenterology, Qilu Hospital, Shandong University

Jinan, Shandong, 250012, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Taken biopsies during Colonoscopy

MeSH Terms

Conditions

Irritable Bowel Syndrome

Interventions

Colonoscopy

Condition Hierarchy (Ancestors)

Colonic Diseases, Functional; Colonic Diseases; Intestinal Diseases; Gastrointestinal Diseases; Digestive System Diseases

Intervention Hierarchy (Ancestors)

Endoscopy, Gastrointestinal; Endoscopy, Digestive System; Diagnostic Techniques, Digestive System; Diagnostic Techniques and Procedures; Diagnosis; Endoscopy; Diagnostic Techniques, Surgical; Digestive System Surgical Procedures; Surgical Procedures, Operative; Minimally Invasive Surgical Procedures

Study Officials

• xiuli zuo, PHD

  Department of Gastroenterology, Qilu Hospital

  STUDY DIRECTOR

Central Study Contacts

xiuli zuo, PHD

CONTACT

15588818685; xiulizuo@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Vice president of Qilu Hospital

Study Record Dates

• First Submitted: July 19, 2015
• First Posted: July 30, 2015
• Study Start: June 1, 2015
• Primary Completion: April 1, 2016
• Study Completion: June 1, 2016
• Last Updated: July 30, 2015

Record last verified: 2015-07

Locations

CN (1)