MISSION Severe Asthma Modern Innovative Solutions to Improve Outcomes in Severe Asthma.

NCT02509130 | Completed

• 1 other identifier: PHT/2015/15
• Study Type: observational
• Target: 92
• Locations: 1 country
• Sites: 1

Brief Summary

MISSION is a new and novel way of delivering highly specialised asthma care and has the potential to change the way asthma care across the United Kingdom (UK) is delivered as well as services for other long term health conditions. The MISSION model is the first model of this type and the current research study aims to evaluate its success and to compare the MISSION service to current care delivery. This will be done in several different ways. The study is a mixed methods evaluation of the new service comparing outcomes before and after the intervention using retrospective data analysis and prospective qualitative interview. A control arm of patients not exposed to, but eligible for, the new intervention will also be included. The study will be conducted at Portsmouth Hospitals National Health Service (NHS) Trust and will recruit patients who attended MISSION clinics, outpatient asthma clinics, staff who attended MISSION clinics in a professional capacity and patients from GP surgeries where MISSION clinics were held who did not attend.

Conditions

Asthma

Keywords

Severe Asthma; Asthma; Specialised Asthma Care; Asthma Care

Outcome Measures

Primary Outcomes (1)

• Asthma control as measured by exacerbation frequency for all patients

  The primary endpoint is asthma control as measured by exacerbation frequency (defined as deterioration in symptoms requiring ≥30mg prednisolone or equivalent for ≥3 days) for all patients

  6 months

Secondary Outcomes (38)

• Short acting bronchodilator (SABA) use

  6 months

• Exacerbation frequency

  6 months

• Health care usage costs for asthma and number of contacts

  6 months

• Assessment of co-morbidity

  6 months

• Assessment of inhaler technique and recommendations for inhaler devices.

  6 months

Study Arms (4)

Patients who attended RAAC/SAAC.

Patients who have previously attended the Rapid Access Asthma Clinic (RAAC) will be approached for the quantitative study. Patients who went onto the attend the Severe Asthma Assessment Clinics (SAAC) will also be approached for the quantitative and qualitive parts of the study.

Patients eligible for RAAC, but DNA'd

Patients identified by the GP search, who did not attend the previous MISSION clinics will be approached to participate in the quantitative part of the study.

Asthma Outpatients

Patients who are attending outpatient clinics as new referrals will be approached to participate in the quantitative part of the study.

Healthcare Professionals

Healthcare professionals who performed the MISSION RAAC or SAAC will be approached for qualitative interview part of the study only.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Participants with uncontrolled or potentially severe asthma identified from GP records by the MISSION team and new referrals to an asthma specialist clinic at Queen Alexandra Hospital between May and August 2014. Study participants for qualitative interview will be recruited from patients who attended MISSION SAAC days and staff who attended MISSION RAAC or SAAC days.

You may qualify if:

• Male or Female, aged 18 years or above.
• Is in one of the following population groups:
• Attended the MISSION RAAC or
• Attended the MISSION SAAC or
• Identified as uncontrolled asthma by record searches and invited to MISSION RAAC but did not attend - 'primary care patients' or
• Has been referred to the specialist asthma clinic at Queen Alexandra Hospital - 'outpatient severe asthma patients' or
• Attended the MISSION RAAC or SAAC as a health care professional
• Participant is willing and able to give informed consent for participation in the study.

You may not qualify if:

• The patient is unable or unwilling to give consent

Sponsors & Collaborators

• Portsmouth Hospitals NHS Trust: lead
• University of Portsmouth: collaborator

Study Sites (1)

Portsmouth Hospitals NHS Trust, Queen Alexandra Hospital

Portsmouth, Hampshire, PO6 3LY, United Kingdom

Location

Related Publications (4)

• Hoddinott P, Pill R. Qualitative research interviewing by general practitioners. A personal view of the opportunities and pitfalls. Fam Pract. 1997 Aug;14(4):307-12. doi: 10.1093/fampra/14.4.307.

  PMID: 9283852 BACKGROUND

• Hoddinott P, Pill R. A review of recently published qualitative research in general practice. More methodological questions than answers? Fam Pract. 1997 Aug;14(4):313-9. doi: 10.1093/fampra/14.4.313.

  PMID: 9283853 BACKGROUND

• Bulpitt H, Martin PJ. Who am I and what am I doing? Becoming a qualitative research interviewer. Nurse Res. 2010;17(3):7-16. doi: 10.7748/nr2010.04.17.3.7.c7741.

  PMID: 20450084 BACKGROUND

• Richards H, Emslie C. The 'doctor' or the 'girl from the University'? Considering the influence of professional roles on qualitative interviewing. Fam Pract. 2000 Feb;17(1):71-5. doi: 10.1093/fampra/17.1.71.

  PMID: 10673494 BACKGROUND

Related Links

• Asthma UK
• Department of Health - An outcomes strategy for people with chronic obstructive pulmonary disease (COPD) and asthma in England
• Five year forward view, NHS England

MeSH Terms

Conditions

Asthma

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Professor Anoop J Chauhan

  Portsmouth Hospitals NHS Trust

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 13, 2015
• First Posted: July 27, 2015
• Study Start: June 1, 2015
• Primary Completion: March 1, 2016
• Study Completion: March 1, 2016
• Last Updated: September 27, 2016

Record last verified: 2016-09

Locations

GB (1)