NCT02507271|Completed
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Sponsor study identifier
interventional
100
1 country
1
Study Start
August 1, 2010
Actual (reported)Primary Completion
March 25, 2021
Actual (reported)Study Completion
March 25, 2021
Actual (reported)The purpose of this project is to test the hypothesis that Speed of Information Processing (SIP) deficits in acquired brain injury (ABI) can be remediated. The majority of individuals with acquired brain injuries have speed of information processing deficits as part of the cognitive sequelae of the brain injury. Empirical research is expected to demonstrate the efficacy of computerized cognitive Speed of Information Processing (SIP) training in individuals with ABI. Study participants will be asked to attend two study visits over the course of approximately 13 weeks. Participants will be randomly assigned to either the experimental or control group.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 25, 2021
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 1, 2010
Actual (reported)July 21, 2015
Actual (reported)July 23, 2015
Actual (reported)March 25, 2021
Actual (reported)March 25, 2021
Actual (reported)Reading ability
Wechsler Test of Adult Reading (WTAR). The WTAR is a measure that reliably estimates levels of intelligence by asking the participant to read aloud the words on an established reading list.
Change from baseline after 13 weeks
Speed of Information Processing
1\) The Paced Auditory Serial Addition Test (PASAT), which is designed to assess complex mental manipulation by adding the two most recent numbers that are presented auditorily. 2) The Symbol Digit Coding subtest of the CNS-Vital Signs neurocognitive battery, which requires the examinee to type and respond as quickly as possible the appropriate number that matches the special symbol. 3) The Stroop subtest of the CNS-Vital Signs neurocognitive battery: The Stroop Test has three parts to it. A) Read the word that is a name of a color as quickly as possible within 90 seconds. B) Name the color of ink that four X's as quickly as possible within 90 seconds. C) Name the color of the ink that the word is written in. The word is a color of ink that is incongruent to the color of the print. The participant is required to name as many inks as possible within 90 seconds.
Change from baseline after 13 weeks
Executive Functions
1\) Trail Making Test, Part A \& B: This test measures efficiency of visual search and set shifting while alternating between letters and numbers. 2) Wisconsin Card Sorting Test, this test measures mental flexibility, set shifting and hypothesis testing. 3) The Non-Verbal Reasoning subtest of the CNS- Vital Signs neurocognitive battery, which is a measure of non-verbal reasoning and pattern identification.
Change from baseline after 13 weeks
Neuroimaging
Change from baseline after 13 weeks
This intervention involves work on a computer by responding to sounds for five hours a week, approximately one hour a day five days a week at the Rusk Institute for Rehabilitation.
This intervention involves weekly telephone calls over a period of approximately 8 weeks to inquire about the participant's involvement in cognitively stimulating activities (such as reading, working on the computer, puzzles, etc.)
NYU Langone Medical Center, Rusk Institute for Rehabilitation
New York, New York, 10016, United States
Lambez B, Vakil E, Voelbel GT. The effects of background factors on working memory and processing speed in auditory processing intervention. Neuropsychol Rehabil. 2026 Jul 28:1-18. doi: 10.1080/09602011.2026.2705980. Online ahead of print.
Gerald Voelbel
New York University
100 participants (actual enrollment reported by the registry).
First Submitted
July 21, 2015
First Posted
July 23, 2015
Study Start
August 1, 2010
Actual (reported)Clinical Validation of Self-Pacing Algorithms on Step Length Symmetry in Hemiplegic Populations
Working Memory and Attention
1\) The Continuous Performance subtest of the CNS- Vital Signs neurocognitive battery. The Continuous Performance test assesses sustained attention and reaction time to targets presented on the computer. 2) The Shifting Attention subtest of the CNS- Vital Signs neurocognitive battery will be administered to assess the participant's ability to maintain attention while switching between sets of target. 3) Four-Parts Continuous performance subtest of the CNS- Vital Signs neurocognitive battery, which is a measure of working memory and sustained attention. In addition to these working memory and attention tasks, a verbal digit-span task, this is a standardized measure of verbal working memory.
Change from baseline after 13 weeks
Visual and Verbal Memory
Verbal memory will be assessed with the Verbal Memory subtest of the CNS- Vital Signs neurocognitive battery. Participants will learn a list of words and then will be assessed for immediate recall and delayed recall.
Change from baseline after 13 weeks
Speech Perception
Participants will be given a hearing screening which will take approximately 5 minutes. Participants will listen to speech sounds, words, or sentences over headphones and will make judgments about what they hear, by speaking a response, pushing a button, typing a response, or touching a computer screen. They will either be asked to make judgments about what they hear (e.g., what was the word) or the voice of the person who spoke.
Change from baseline after 13 weeks
Depression
Beck Depression Inventory -II: This is a standardized instrument for the assessment of depression with a self-report questionnaire. Participants will endorse the level of disturbance which best describe their mood over 21 items that are characteristic of depression
Change from baseline after 13 weeks
Anxiety
Beck Anxiety Inventory: The BAI is a self-report instrument for the assessment of anxiety. The BAI consists of 21 items, each describing a common symptom of anxiety on which the respondent rates how much they have been bothered by the symptoms over the last week
Change from baseline after 13 weeks
Cognitive Questionnaire
The Cognitive Self-Report Questionnaire assesses perceptions of cognitive abilities). The Cognitive Self-Report Questionnaire consists of 25 statements about cognition and mood in everyday life over the past 2 weeks.
Change from baseline after 13 weeks
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
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Primary Completion
March 25, 2021
Actual (reported)Study Completion
March 25, 2021
Actual (reported)Last Updated
March 30, 2021
Record last verified: 2021-03
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Source: ClinicalTrials.gov.
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