Lysine Oxidation in Response to Arginine Supplementation

NCT02499926 | Completed DMC

• 1 other identifier: H15-01151
• Study Type: interventional
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

This research study is investigating if consuming more of one amino acid (arginine) influences the digestion and absorption of another amino acid (lysine) due to competition in digestion, in a healthy adult population.

Conditions

Physiologically Healthy Adult Male Participants

Outcome Measures

Primary Outcomes (1)

• 13CO2 production

  Urine, plasma and breath samples will be collected during the study to measure the rate of oxidation of tracer with graded intake of arginine

  8 hours (1 study day)

Study Arms (1)

Dietary supplement: Arginine

EXPERIMENTAL

Graded arginine excess intake

Dietary Supplement: Arginine

Interventions

Arginine DIETARY_SUPPLEMENT

Graded arginine excess intake will start at 50mg/kg/d on study day 1 followed by 100 mg/kg/d on study day 2 till the level reaches 300mg/kg/d on study day 6. Consisting of oral consumption of eight hourly experimental meals per study day - Includes 4 tracer free experimental meals containing a mixture of free amino acids, calories from a flavored liquid and protein free cookies and 4- labeled amino acid experimental meals.

Dietary supplement: Arginine

Eligibility Criteria

• Age: 19 Years - 50 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• You are 19 to 50 years-of-age
• Male
• Classified as normal body weight and BMI (18.5-25 kg/m2)
• Free of any concurrent illness (cold, flu, vomiting etc.)
• Not be claustrophobic (we will place a clear hood, which can easily be removed, over your head for approximately 20 min to measure your energy expenditure).
• Not be enrolled in any other research studies (as this may affect our study results)

You may not qualify if:

• You are not in good health or have a metabolic, neurological, genetic, or immune disorder, including diabetes and hypertension
• You are classified as underweight (\<18.5 kg/m2), overweight (25-30 kg/m2), or obese (\>30 kg/m2) using the BMI classification
• You are allergic to milk, eggs and egg protein
• You are claustrophobic (we will place a clear hood, which can easily be removed, over your head for approximately 20 min to measure your energy expenditure)
• You are currently enrolled in other research studies (as this may affect our study results)

Sponsors & Collaborators

• University of British Columbia: lead

Study Sites (1)

BC Children;s Hospital Research Institute, University of British Columbia

Vancouver, British Columbia, V5Z4H4, Canada

Location

MeSH Terms

Interventions

Arginine

Intervention Hierarchy (Ancestors)

Amino Acids, Basic; Amino Acids; Amino Acids, Peptides, and Proteins; Amino Acids, Diamino; Amino Acids, Essential

Study Officials

• Rajavel Elango, PhD

  University of British Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: July 14, 2015
• First Posted: July 16, 2015
• Study Start: July 1, 2015
• Primary Completion: December 1, 2017
• Study Completion: January 12, 2024
• Last Updated: July 25, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)