Gait Asymmetry Assessed Using Portable Gait Analysis System

NCT02489188 | Completed

• 1 other identifier: 2015-139
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

To date, detailed analysis of movement patterns in orthopaedic conditions are mainly performed in research projects. Because these tests are time consuming, they are not feasible in clinical routine or in standard examinations. Novel technologies allow capturing detailed movement patters within a few minutes. The aim of this regional study is to compare aspects of movement tasks measured using a mobile gait analysis system to those measured using laboratory based systems and to determine aspects of gait patterns relevant for different orthopaedic conditions. Moreover, the researchers will investigate if these relevant aspects can be altered using surgical treatment or manual therapy.

Conditions

Ankle Osteoarthritis; Knee Osteoarthritis; Hip Osteoarthritis; Lumbar Spine Stenosis; Muscle Contracture

Keywords

gait asymmetry; joint angles

Outcome Measures

Primary Outcomes (1)

• symmetry index

  gait asymmetry assessed using a portable and laboratory gait analysis systems

  up to 6 months

Secondary Outcomes (4)

• change in symmetry index

  up to 6 months

• maximum isokinetic joint moment [Nm]

  up to 6 months

• relative electromyographic (EMG) intensity

  up to 6 months

• differences between maximum flexion and extension [degrees]

  up to 6 months

Study Arms (6)

ankle osteoarthritis

patients with ankle osteoarthritis scheduled for arthroplasty

Procedure: arthroplasty; Other: manual therapy

knee osteoarthritis

patients with knee osteoarthritis scheduled for arthroplasty

Procedure: arthroplasty; Other: manual therapy

hip osteoarthritis

patients with hip osteoarthritis scheduled for arthroplasty

Procedure: arthroplasty; Other: manual therapy

lumbar spinal stenosis

patients with lumbar spinal stenosis scheduled for lumbar spinal stenosis decompression

Other: manual therapy; Procedure: lumbar spinal stenosis decompression

muscle contracture

patients with functionally limited range of motion at the knee because of muscle contracture scheduled for manual therapy

Other: manual therapy

healthy subjects

healthy subjects

Interventions

arthroplasty PROCEDURE

patients, who are scheduled for arthroplasty, will be measured before and on average 6 months after surgery

ankle osteoarthritis; hip osteoarthritis; knee osteoarthritis

manual therapy OTHER

patients, who are scheduled for manual therapy, will be measured before, immediately and on average 1 week after treatment

ankle osteoarthritis; hip osteoarthritis; knee osteoarthritis; lumbar spinal stenosis; muscle contracture

lumbar spinal stenosis decompression PROCEDURE

patients, who are scheduled for lumbar spinal stenosis decompression, will be measured before and on average 6 months after surgery

lumbar spinal stenosis

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects will be recruited from patients visiting the outpatient clinic or are scheduled for arthroplasty or LSS decompression at the University Hospital Basel and from the surrounding community.

You may qualify if:

• Age ≥ 40 years, for patients: diagnosed osteoarthritis at the ankle, knee or hip, lumbar spinal stenosis or limited range of motion at the knee

You may not qualify if:

• Body mass index \> 35kg/m2
• Use of walking aids
• Inability to walk for 6 minutes
• Neuromuscular disorders affecting gait
• Cardiovascular disease
• Inability to follow procedures due to psychological disorders or dementia

Sponsors & Collaborators

• University Hospital, Basel, Switzerland: lead

Study Sites (1)

University Hospital Basel

Basel, Canton of Basel-City, 4031, Switzerland

Location

Related Publications (12)

• Horstmann T, Listringhaus R, Haase GB, Grau S, Mundermann A. Changes in gait patterns and muscle activity following total hip arthroplasty: a six-month follow-up. Clin Biomech (Bristol). 2013 Aug;28(7):762-9. doi: 10.1016/j.clinbiomech.2013.07.001. Epub 2013 Jul 29.

  PMID: 23906936 BACKGROUND

• Horstmann T, Listringhaus R, Brauner T, Grau S, Mundermann A. Minimizing preoperative and postoperative limping in patients after total hip arthroplasty: relevance of hip muscle strength and endurance. Am J Phys Med Rehabil. 2013 Dec;92(12):1060-9. doi: 10.1097/PHM.0b013e3182970fc4.

  PMID: 23739275 BACKGROUND

• Horstmann T, Vornholt-Koch S, Brauner T, Grau S, Mundermann A. Impact of total hip arthroplasty on pain, walking ability, and cardiovascular fitness. J Orthop Res. 2012 Dec;30(12):2025-30. doi: 10.1002/jor.22163. Epub 2012 May 31.

  PMID: 22653634 BACKGROUND

• Mundermann A, Mundermann L, Andriacchi TP. Amplitude and phasing of trunk motion is critical for the efficacy of gait training aimed at reducing ambulatory loads at the knee. J Biomech Eng. 2012 Jan;134(1):011010. doi: 10.1115/1.4005540.

  PMID: 22482665 BACKGROUND

• Mundermann A, Asay JL, Mundermann L, Andriacchi TP. Implications of increased medio-lateral trunk sway for ambulatory mechanics. J Biomech. 2008;41(1):165-70. doi: 10.1016/j.jbiomech.2007.07.001. Epub 2007 Aug 3.

  PMID: 17678933 BACKGROUND

• Fisher DS, Dyrby CO, Mundermann A, Morag E, Andriacchi TP. In healthy subjects without knee osteoarthritis, the peak knee adduction moment influences the acute effect of shoe interventions designed to reduce medial compartment knee load. J Orthop Res. 2007 Apr;25(4):540-6. doi: 10.1002/jor.20157.

  PMID: 17205556 BACKGROUND

• Mundermann A, Dyrby CO, Andriacchi TP. Secondary gait changes in patients with medial compartment knee osteoarthritis: increased load at the ankle, knee, and hip during walking. Arthritis Rheum. 2005 Sep;52(9):2835-44. doi: 10.1002/art.21262.

  PMID: 16145666 BACKGROUND

• Mundermann A, Dyrby CO, Hurwitz DE, Sharma L, Andriacchi TP. Potential strategies to reduce medial compartment loading in patients with knee osteoarthritis of varying severity: reduced walking speed. Arthritis Rheum. 2004 Apr;50(4):1172-8. doi: 10.1002/art.20132.

  PMID: 15077299 BACKGROUND

• Nuesch C, Huber C, Paul J, Henninger HB, Pagenstert G, Valderrabano V, Barg A. Mid- to Long-term Clinical Outcome and Gait Biomechanics After Realignment Surgery in Asymmetric Ankle Osteoarthritis. Foot Ankle Int. 2015 Aug;36(8):908-18. doi: 10.1177/1071100715577371. Epub 2015 Mar 20.

  PMID: 25795650 BACKGROUND

• Nuesch C, Valderrabano V, Huber C, Pagenstert G. Effects of supramalleolar osteotomies for ankle osteoarthritis on foot kinematics and lower leg muscle activation during walking. Clin Biomech (Bristol). 2014 Mar;29(3):257-64. doi: 10.1016/j.clinbiomech.2013.12.015. Epub 2013 Dec 31.

  PMID: 24445126 BACKGROUND

• Nuesch C, Barg A, Pagenstert GI, Valderrabano V. Biomechanics of asymmetric ankle osteoarthritis and its joint-preserving surgery. Foot Ankle Clin. 2013 Sep;18(3):427-36. doi: 10.1016/j.fcl.2013.06.002. Epub 2013 Jul 24.

  PMID: 24008209 BACKGROUND

• Nuesch C, Valderrabano V, Huber C, von Tscharner V, Pagenstert G. Gait patterns of asymmetric ankle osteoarthritis patients. Clin Biomech (Bristol). 2012 Jul;27(6):613-8. doi: 10.1016/j.clinbiomech.2011.12.016. Epub 2012 Jan 18.

  PMID: 22261013 BACKGROUND

MeSH Terms

Conditions

Osteoarthritis, Knee; Osteoarthritis, Hip; Contracture

Interventions

Arthroplasty; Musculoskeletal Manipulations

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Muscular Diseases

Intervention Hierarchy (Ancestors)

Orthopedic Procedures; Surgical Procedures, Operative; Plastic Surgery Procedures; Complementary Therapies; Therapeutics; Physical Therapy Modalities; Rehabilitation

Study Officials

• Annegret Mündermann, PhD

  University Hospital, Basel, Switzerland

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 23, 2015
• First Posted: July 2, 2015
• Study Start: June 1, 2015
• Primary Completion: September 30, 2019
• Study Completion: September 30, 2019
• Last Updated: November 15, 2019

Record last verified: 2019-11

Locations

CH (1)