Effect of the High Impact Exercise on Bone Density in Prepuberal Girls

NCT02488122 | Suspended

• 1 other identifier: FSFBK1
• Study Type: interventional
• Target: 276
• Locations: 0 countries
• Sites: N/A

Brief Summary

Osteoporosis has become a worldwide concern an a matter of public health as osteoporosis is a major contributing factor associated with insufficiency fracture of the spine, wrist and proximal femur, and as a result, can diminish quality of life as well as increase direct and indirect healthcare costs. The pathophysiology of osteoporosis is based on two main factors; low bone mass and age associated architectural changes within the bone, high impact exercise in childhood can improve the peak bone mass and bone architecture. The evidence suggests that bone adaptation to increased load is optimal in early puberty (Tanner stages I and II) since around 30% of total body adult bone mass is accrued during this period. However, the optimal exercise program for increasing peak bone mineral content is still unclear. Therefore, the aim of this study is to assess if 15 minutes of high-impact exercise three times per week improve areal bone mineral density assessed by DXA of pre pubertal girls after a ten-month regimen compared to low-impact exercise. This information could highly impact the development of public health policies directed to pre pubertal girls.

Conditions

Bone Loss, Age-Related,

Keywords

Bone Mineral Density; Isometric Exercise; Bone Growth

Outcome Measures

Primary Outcomes (1)

• bone mineral density (BMD) are presented for the total Body total bone mineral density

  whole body whole Amount of mineral matter per square centimeter of bones.

  36 weeks

Study Arms (2)

High Impact Exercise

EXPERIMENTAL

weight bearing exercises, jumps, plyometric exercises

Other: High Impact Exercise

Low Impact Exercise

SHAM COMPARATOR

Walking, Strength training, Cycling, Yoga.

Other: Low Impact Exercise

Interventions

High Impact Exercise OTHER

In these workouts, both feet leave the ground at the same time.

High Impact Exercise

Low Impact Exercise OTHER

A workout is low-impact if at least one of your feet remains in contact with the ground at all times.

Low Impact Exercise

Eligibility Criteria

• Age: 8 Years - 10 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Girls between ages 8 to 10
• Tanner I

You may not qualify if:

• Precocious menarche (within the selected timeframe)
• Chronic disorders or medications known to affect bone metabolism or musculoskeletal function.
• Body Mass Index 30 or higher
• Regular vigorous physical activity (training more than 8 hours per week)

Sponsors & Collaborators

• Fundación Santa Fe de Bogota: lead
• Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnología (COLCIENCIAS): collaborator

Related Publications (9)

• Bass SL, Saxon L, Daly RM, Turner CH, Robling AG, Seeman E, Stuckey S. The effect of mechanical loading on the size and shape of bone in pre-, peri-, and postpubertal girls: a study in tennis players. J Bone Miner Res. 2002 Dec;17(12):2274-80. doi: 10.1359/jbmr.2002.17.12.2274.

  PMID: 12469922 BACKGROUND

• Sayers A, Mattocks C, Deere K, Ness A, Riddoch C, Tobias JH. Habitual levels of vigorous, but not moderate or light, physical activity is positively related to cortical bone mass in adolescents. J Clin Endocrinol Metab. 2011 May;96(5):E793-802. doi: 10.1210/jc.2010-2550. Epub 2011 Feb 16.

  PMID: 21325463 BACKGROUND

• Hernandez CJ, Beaupre GS, Carter DR. A theoretical analysis of the relative influences of peak BMD, age-related bone loss and menopause on the development of osteoporosis. Osteoporos Int. 2003 Oct;14(10):843-7. doi: 10.1007/s00198-003-1454-8. Epub 2003 Aug 7.

  PMID: 12904837 BACKGROUND

• Fuchs RK, Bauer JJ, Snow CM. Jumping improves hip and lumbar spine bone mass in prepubescent children: a randomized controlled trial. J Bone Miner Res. 2001 Jan;16(1):148-56. doi: 10.1359/jbmr.2001.16.1.148.

  PMID: 11149479 BACKGROUND

• Kontulainen SA, Hughes JM, Macdonald HM, Johnston JD. The biomechanical basis of bone strength development during growth. Med Sport Sci. 2007;51:13-32. doi: 10.1159/000103002.

  PMID: 17505117 BACKGROUND

• Rauch F, Schoenau E. Changes in bone density during childhood and adolescence: an approach based on bone's biological organization. J Bone Miner Res. 2001 Apr;16(4):597-604. doi: 10.1359/jbmr.2001.16.4.597.

  PMID: 11315987 BACKGROUND

• Grimston SK, Willows ND, Hanley DA. Mechanical loading regime and its relationship to bone mineral density in children. Med Sci Sports Exerc. 1993 Nov;25(11):1203-10.

  PMID: 8289606 BACKGROUND

• Witzke KA, Snow CM. Effects of plyometric jump training on bone mass in adolescent girls. Med Sci Sports Exerc. 2000 Jun;32(6):1051-7. doi: 10.1097/00005768-200006000-00003.

  PMID: 10862529 BACKGROUND

• MacKelvie KJ, McKay HA, Petit MA, Moran O, Khan KM. Bone mineral response to a 7-month randomized controlled, school-based jumping intervention in 121 prepubertal boys: associations with ethnicity and body mass index. J Bone Miner Res. 2002 May;17(5):834-44. doi: 10.1359/jbmr.2002.17.5.834.

  PMID: 12009014 BACKGROUND

MeSH Terms

Conditions

Osteoporosis

Condition Hierarchy (Ancestors)

Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• ANA KARINA SARMIENTO, DDS

  FUNDACION SANTA FE DE BOGOTA

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: ORAL AND MAXILLOFACIAL SURGEON

Study Record Dates

• First Submitted: June 30, 2015
• First Posted: July 2, 2015
• Study Start: February 1, 2016
• Primary Completion: November 1, 2016
• Study Completion: May 1, 2017
• Last Updated: February 11, 2016

Record last verified: 2016-02