Sit-to-stand and Peripheral Muscle Strength in COPD

NCT02487875 | Completed

• 1 other identifier: Maugeri1
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Individuals with COPD may present reduced peripheral muscle strength, which leads to impaired mobility. Comprehensive pulmonary rehabilitation (PR) should include strength training, in particular to lower limbs. Furthermore, simple tools for the assessment of lower extremity muscles' performance are required. Objectives: To assess the muscle strength of COPD patients by the sit-to-stand test (STST) as compared to the one-repetition maximum (1-RM), considered as the gold standard in non-laboratory situations, and to evaluate the responsiveness of STST to a PR program with specific strength training (SPR), compared to usual PR program (UPR). Methods: 60 moderate-to-severe COPD inpatients were randomly included into either the SPR or into the UPR. 30-sec STST, 1-min STST, 1-RM and 6MWT were assessed before and after PRs.

Conditions

COPD

Keywords

Sit-to-stand test; Muscle strength; Pulmonary rehabilitation

Outcome Measures

Primary Outcomes (1)

• evaluate the lower limbs' muscle strength by two STSTs (30-sec and 1-min), as compared to the 1-RM in patients with clinically stable COPD, both at baseline and after a PR with specific lower limbs' muscle strength training (SPR).

  1 month

Study Arms (2)

COPD patients -study group

EXPERIMENTAL

COPD inpatients GOLD2-4, in stable conditions,hospitalized to follow a pulmonary rehabilitation programme. The study group performs in addition to the standard programme, also a peripheric muscle strength training

Other: rehabilitation

COPD patients -control group

ACTIVE COMPARATOR

COPD inpatients GOLD2-4, in stable conditions,hospitalized to follow a pulmonary rehabilitation programme

Other: rehabilitation

Interventions

rehabilitation OTHER

COPD patients -control group; COPD patients -study group

Eligibility Criteria

• Age: 18 Years - 87 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• diagnosis for COPD according to the GOLD criteria.
• no exacerbations over the previous four weeks
• completing PR program
• smoking history ≥10 pack years
• regular treatment with inhaled bronchodilators and inhaled steroids

You may not qualify if:

• any unstable medical condition
• Contraindications for participation in the PR program included musculoskeletal disorders, malignant diseases, unstable cardiac condition, and lack of adherence to the program

Sponsors & Collaborators

• Maugeri Foundation: lead

Study Sites (1)

Fondazione Maugeri di Tradate

Tradate, VA, 21049, Italy

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Interventions

Rehabilitation

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: June 25, 2015
• First Posted: July 2, 2015
• Study Start: January 1, 2014
• Primary Completion: April 1, 2015
• Study Completion: April 1, 2015
• Last Updated: July 2, 2015

Record last verified: 2015-06

Locations

IT (1)