Muscle Metabolic Function in Older Adults With Different Vitamin D Status Before and After Exercise
A Pilot Study Investigating Differences in Muscle Metabolic Function in Individuals Aged 65-75 Years With Different Vitamin D Status Before and After 7-days of Aerobic Training
1 other identifier
interventional
7
1 country
1
Brief Summary
This is a small pilot aerobic training trial designed to examine differences between normal-high and low vitamin D levels and 7-days of aerobic training on local VO2 measured by non-invasive Hybrid Diffuse Optical Spectroscopy.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Mar 2013
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2013
CompletedFirst Submitted
Initial submission to the registry
April 25, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2015
CompletedFirst Posted
Study publicly available on registry
June 30, 2015
CompletedMarch 17, 2017
March 1, 2017
7 months
April 25, 2013
March 15, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Muscle VO2 consumption
The objective is to examine the difference in gastrocnemius VO2 consumption in individuals that either have normal-high or low 25(OH)D and are undergoing 7-days of a treadmill training program.
Up to 3 months
Study Arms (2)
Low 25(OH)D
OTHERWe will recruit individuals with low 25(OH)D (\<30ng/mL).
High 25(OH)D
OTHERWe will recruit individuals with higher 25(OH)D (at least 20ng/mL units higher then that of the "low 25(OH)D group).
Interventions
For 7 consecutive days, subjects will perform up to 45 minutes of exercise consisting of treadmill walking at a progressive intensity of about 60-65% of their maximum heart rate. This heart rate range is estimated to be below 60% VO2 max.
Eligibility Criteria
You may qualify if:
- years of age
You may not qualify if:
- Currently have or have a history of cardiovascular or pulmonary disease that would preclude the involvement in the performance of exercise.
- Uncontrolled diabetes or hypertension.
- History of neurological conditions related to spinal derangement, disk disease, peripheral neuropathies, tremor and rigidity
- History of leg/hip trauma, inflammation, infection rhabdomyolysis, or leg surgery in the past 3 months
- Have a diagnosis of osteoporosis (as determined by DXA)
- Participated in a resistance or aerobic training program in the last 3 months
- Engage in more than 1 hr/week of vigorous activity
- Body mass index \>29
- On hormone replacement therapy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Kentucky
Lexington, Kentucky, 40506, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
David T Thomas, PhD
University of Kentucky
- STUDY DIRECTOR
Maja Redzic, MS
University of Kentucky
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- SCREENING
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Ph.D., RD, CSSD, CSCS
Study Record Dates
First Submitted
April 25, 2013
First Posted
June 30, 2015
Study Start
March 1, 2013
Primary Completion
October 1, 2013
Study Completion
June 1, 2015
Last Updated
March 17, 2017
Record last verified: 2017-03