The Difference in Duration of Sciatic Nerve Block Between Diabetic and Non-diabetic Patients

NCT02482831 | Unknown DMC

• 1 other identifier: anesthesiologyPUMCH002
• Study Type: observational
• Target: 53
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the sensory and motor block duration and the incidence of nerve injury after sciatic nerve block between diabetic and non-diabetic patients, and screen for the factors that may affect the block recovery.

Conditions

Sciatic Nerve Block

Keywords

Sciatic nerve block; block duration; Semmes Weinstein monofilaments; fasting blood glucose; nerve block; sensory block duration; motor block duration

Outcome Measures

Primary Outcomes (2)

• Duration of sensory block

  Sensory block is measured by Semmes Weinstein monofilaments. The block is measured at baseline, and every 2hours in 48 hours after the block.

  48 hours

• Duration of motor block

  Motor blocks is visualized. The block is measured at baseline, and every 2hours in 48 hours after the block

  48 hours

Study Arms (2)

Diabetes

Diabatic participants who experienced unilateral lower limb surgery and received an ultrasound-guided (nerve stimulator assisted) subgluteal sciatic nerve block with 0.75% ropivacaine 20ml in Peking Union Medical College Hospital were selected.

Procedure: Subgluteal sciatic nerve block

non-Diabetes

Non-diabatic participants who experienced unilateral lower limb surgery and received an ultrasound-guided (nerve stimulator assisted) subgluteal sciatic nerve block with 0.75% ropivacaine 20ml in Peking Union Medical College Hospital were selected.

Procedure: Subgluteal sciatic nerve block

Interventions

Subgluteal sciatic nerve block PROCEDURE

All patients (either diabetic or non-diabetic patients) received an ultrasound-guided (nerve stimulator assisted) subgluteal sciatic nerve block with 0.75% ropivacaine 20ml.

Diabetes; non-Diabetes

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who undergo unilateral lower limb surgery in Peking Union Medical College Hospital.

You may qualify if:

• American Society of Anesthesiologists :I-III;
• Age\>=18 years;
• Undergo unilateral lower limb surgery;
• Sign consent form.

You may not qualify if:

• Refuse regional Anesthesia;
• Thresh of sensory \>10g;
• Dyskinesia;
• Bleeding disorder;
• Regional skin infection;
• Regional drug allergy;
• Renal disfunction;
• Incompliant to study;
• Drug abuse.

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Study Sites (1)

Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

RECRUITING

Related Publications (7)

• Gebhard RE, Nielsen KC, Pietrobon R, Missair A, Williams BA. Diabetes mellitus, independent of body mass index, is associated with a "higher success" rate for supraclavicular brachial plexus blocks. Reg Anesth Pain Med. 2009 Sep-Oct;34(5):404-7. doi: 10.1097/AAP.0b013e3181ada58d.

  PMID: 19920415 BACKGROUND

• Kalichman MW, Calcutt NA. Local anesthetic-induced conduction block and nerve fiber injury in streptozotocin-diabetic rats. Anesthesiology. 1992 Nov;77(5):941-7. doi: 10.1097/00000542-199211000-00017.

  PMID: 1443749 BACKGROUND

• Kroin JS, Buvanendran A, Williams DK, Wagenaar B, Moric M, Tuman KJ, Kerns JM. Local anesthetic sciatic nerve block and nerve fiber damage in diabetic rats. Reg Anesth Pain Med. 2010 Jul-Aug;35(4):343-50. doi: 10.1097/aap.0b013e3181e82df0.

  PMID: 20607875 BACKGROUND

• Cuvillon P, Reubrecht V, Zoric L, Lemoine L, Belin M, Ducombs O, Birenbaum A, Riou B, Langeron O. Comparison of subgluteal sciatic nerve block duration in type 2 diabetic and non-diabetic patients. Br J Anaesth. 2013 May;110(5):823-30. doi: 10.1093/bja/aes496. Epub 2013 Jan 24.

  PMID: 23348203 RESULT

• Sertoz N, Deniz MN, Ayanoglu HO. Relationship between glycosylated hemoglobin level and sciatic nerve block performance in diabetic patients. Foot Ankle Int. 2013 Jan;34(1):85-90. doi: 10.1177/1071100712460366.

  PMID: 23386766 RESULT

• Kroin JS, Buvanendran A, Tuman KJ, Kerns JM. Effect of acute versus continuous glycemic control on duration of local anesthetic sciatic nerve block in diabetic rats. Reg Anesth Pain Med. 2012 Nov-Dec;37(6):595-600. doi: 10.1097/AAP.0b013e31826742fd.

  PMID: 22996200 RESULT

• Tang S, Wang J, Tian Y, Li X, Cui Q, Xu M, Song X, Zheng Y, Yang H, Ma C, Zhan L, Zhu C, Zhang Y, Yao M, Huang Y. Sex-dependent prolongation of sciatic nerve blockade in diabetes patients: a prospective cohort study. Reg Anesth Pain Med. 2019 Jul 12:rapm-2019-100609. doi: 10.1136/rapm-2019-100609. Online ahead of print.

  PMID: 31302640 DERIVED

Study Officials

• Yuguang Huang, MD

  Peking Union Medical College University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Shuai Tang, MD

CONTACT

13718754540; tangshuai@pumch.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: June 15, 2015
• First Posted: June 26, 2015
• Study Start: September 1, 2014
• Primary Completion: June 1, 2015
• Study Completion: August 1, 2015
• Last Updated: June 26, 2015

Record last verified: 2015-06

Locations

CN (1)