The Influence of Aerobic Exercise on Serum Brain Natriuretic Peptide and C- Reactive Protein in Cardiovascular Disease

NCT02479269 | Completed DMC

• 1 other identifier: CT-P-92-6517
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study was to investigate the effects of 8 weeks of aerobic exercise on serum concentrations of Brain Natriuretic Peptide and C - reactive protein in patients with cardiovascular disease. Patients were divided randomly into two groups: control and experimental aerobic group. This study was done with two - stage blood sampling: at the beginning and at the end of the treatment phase. All subjects were requested to avoid any exercise at least 48 hours before blood sampling. To study Brain Natriuretic Peptide and C - reactive protein changes, 5 milliliters of blood were taken from patient's brachial vein. Blood samples for subsequent measurements were frozen immediately and transported to the Hormone Laboratory for serum separation. The experimental group did the aerobic exercise programs for 8 weeks for 3 sessions per week and the control group did not receive any training. After completion of training, the final blood samplings were performed. Exercise intensity according to the heart rate remained stable until the last week. Brain Natriuretic Peptide and C - reactive protein levels were measured by ELISA tests. All statistical analysis were done using SPSS software (version 16) and at the significance level of p≤ 0.05

Conditions

Cardiovascular Disease

Keywords

Brain Natriuretic Peptide; aerobic execise; C- Reactive Protein

Outcome Measures

Primary Outcomes (2)

• Brain Natriuretic Peptide

  8 weeks

• serum C - reactive protein

  8 weeks

Secondary Outcomes (3)

• serum lipoproteins

  8 weeks

• Body Mass Index

  8 weeks

• blood pressure

  8 weeks

Study Arms (2)

intervention

EXPERIMENTAL

Aerobic exercise+ blood sampling

Other: Aerobic exercise

control

NO INTERVENTION

Blood sampling

Interventions

Aerobic exercise OTHER

Aerobic exercise for 8 weeks

intervention

Eligibility Criteria

• Age: 40 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• In this trial patients with coronary artery disease more than 70 percent at least in one coronary vessel with Ejection Fraction more than 40 percent in recent Echo cardiograph without acute evidence of ischemia or congestive heart failure symptoms were selected and are divide randomly into two groups.

You may not qualify if:

• Patients with acute evidence of ischemia or congestive heart failure symptoms are excluded.

Sponsors & Collaborators

• Shiraz University of Medical Sciences: lead
• Islamic Azad University, Shiraz: collaborator

MeSH Terms

Conditions

Cardiovascular Diseases

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Dr Mohammad Ali Ostovan, Cardiologist

  Shiraz University of Medical Sciences

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Master

Study Record Dates

• First Submitted: June 13, 2015
• First Posted: June 24, 2015
• Study Start: March 1, 2015
• Primary Completion: May 1, 2015
• Study Completion: May 1, 2015
• Last Updated: May 10, 2016

Record last verified: 2016-05